| Record Information |
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| Version | 2.0 |
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| Creation Date | 2009-07-06 21:35:46 UTC |
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| Update Date | 2014-12-24 20:25:47 UTC |
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| Accession Number | T3D2639 |
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| Identification |
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| Common Name | Ohanin |
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| Class | Protein |
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| Description | Ohanin is a peptide toxin produced by the King cobra (Ophiophagus hannah). It is extremely neurotoxic, cardiotoxic, and cytotoxic, and quickly leads to death unless treated with the appropriate antivenom. (2) |
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| Compound Type | - Amide
- Amine
- Animal Toxin
- Natural Compound
- Organic Compound
- Protein
- Snake Venom
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| Protein Structure |  |
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| Synonyms | |
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| Chemical Formula | Not Available |
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| Average Molecular Mass | 21173.945 g/mol |
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| CAS Registry Number | Not Available |
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| Sequence | Not Available |
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| Chemical Taxonomy |
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| Description | Not Available |
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| Kingdom | Organic Compounds |
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| Super Class | Organic Acids |
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| Class | Carboxylic Acids and Derivatives |
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| Sub Class | Amino Acids, Peptides, and Analogues |
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| Direct Parent | Peptides |
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| Alternative Parents | Not Available |
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| Substituents | Not Available |
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| Molecular Framework | Not Available |
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| External Descriptors | Not Available |
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| Biological Properties |
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| Status | Detected and Not Quantified |
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| Origin | Exogenous |
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| Cellular Locations | Not Available |
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| Biofluid Locations | Not Available |
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| Tissue Locations | Not Available |
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| Pathways | Not Available |
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| Applications | Not Available |
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| Biological Roles | Not Available |
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| Chemical Roles | Not Available |
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| Physical Properties |
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| State | Liquid |
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| Appearance | Clear solution. |
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| Experimental Properties | | Property | Value |
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| Melting Point | Not Available | | Boiling Point | Not Available | | Solubility | >10 mg/mL | | LogP | Not Available |
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| Predicted Properties | Not Available |
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| Spectra |
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| Spectra | | Spectrum Type | Description | Splash Key | Deposition Date | View |
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| Toxicity Profile |
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| Route of Exposure | Injection (sting/bite) (3) |
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| Mechanism of Toxicity | Ohanin is extremely neurotoxic, cardiotoxic, and cytotoxic. (2) |
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| Metabolism | Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. |
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| Toxicity Values | LD50: 1.7 mg/kg (Subcutaneous, Mouse) (4)
LD50: 1.31 mg/kg (Intravenous, Mouse) (4)
LD50: 1.644 mg/kg (Intraperitoneal, Mouse) (4) |
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| Lethal Dose | Not Available |
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| Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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| Uses/Sources | Ohanin is a peptide toxin produced by the King cobra (Ophiophagus hannah). (2) |
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| Minimum Risk Level | Not Available |
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| Health Effects | Ohanin is extremely neurotoxic, cardiotoxic, and cytotoxic, and quickly leads to death following cardiovascular collapse, coma, and respiratory failure. (2) |
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| Symptoms | King cobra bites cause severe pain, blurred vision, vertigo, drowsiness, and paralysis. (2) |
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| Treatment | An antivenom exists for King cobra venom. (1) |
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| Normal Concentrations |
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| Not Available |
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| Abnormal Concentrations |
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| Not Available |
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| External Links |
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| DrugBank ID | Not Available |
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| HMDB ID | Not Available |
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| PubChem Compound ID | Not Available |
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| ChEMBL ID | Not Available |
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| ChemSpider ID | Not Available |
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| KEGG ID | Not Available |
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| UniProt ID | P83234 |
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| OMIM ID | |
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| ChEBI ID | Not Available |
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| BioCyc ID | Not Available |
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| CTD ID | Not Available |
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| Stitch ID | Not Available |
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| PDB ID | Not Available |
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| ACToR ID | Not Available |
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| Wikipedia Link | Not Available |
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| References |
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| Synthesis Reference | Not Available |
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| MSDS | Not Available |
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| General References | - Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
- Wikipedia. King Cobra. Last Updated 2 March 2009. [Link]
- Wikipedia. Snake venom. Last Updated 25 July 2009. [Link]
- Thomas S, Griessel E (1999). LD50 Scores for various snakes. [Link]
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| Gene Regulation |
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| Up-Regulated Genes | Not Available |
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| Down-Regulated Genes | Not Available |
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