Lopap (T3D2625)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationXML
Record Information
Version2.0
Creation Date2009-07-06 21:35:28 UTC
Update Date2014-12-24 20:25:47 UTC
Accession NumberT3D2625
Identification
Common NameLopap
ClassProtein
DescriptionLopap is a toxin produced by the caterpillars of the Lonomia moths (especially the species Lonomia obliqua). It is an anticoagulant and is being researched for pharmaceutical purposes. (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Insect Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureNo structure small
Synonyms
Synonym
Lipocalin-1/4
Prothrombin activator
Chemical FormulaNot Available
Average Molecular Mass22432.280 g/mol
CAS Registry NumberNot Available
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureDermal (2)
Mechanism of ToxicityLopap activates thrombin by cleavage of prothrombin, causing thrombus formation, fibrinogen depletion, uncoagulable blood, decreased platelet count, inhibition of collagen-induced platelet aggregation, leukocyte infiltration in lungs, congestion and haemorrhage in renal glomeruli and necrosis in renal distal tubules. (1)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesLopap is a toxin produced by the caterpillars of the Lonomia moths (especially the species Lonomia obliqua). It is an anticoagulant and is being researched for pharmaceutical purposes. (2)
Minimum Risk LevelNot Available
Health EffectsContact with Lonomia venom can cause massive internal haemorrhaging, kidney failure, and destruction of blood cells (haemolysis). This resulting medical syndrome is sometimes called Lonomiasis. (2)
SymptomsContact with Lonomia venom can cause massive internal haemorrhaging, kidney failure, and destruction of blood cells (haemolysis). This resulting medical syndrome is sometimes called Lonomiasis. (2)
TreatmentAn antivenom exists for Lonomia poisoning. (3)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDQ5ECE3
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
PDB IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  2. Wikipedia. Lonomia. Last Updated 3 May 2009. [Link]
  3. Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available