| Record Information |
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| Version | 2.0 |
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| Creation Date | 2009-07-03 22:19:18 UTC |
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| Update Date | 2014-12-24 20:25:40 UTC |
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| Accession Number | T3D2544 |
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| Identification |
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| Common Name | Convulxin |
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| Class | Protein |
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| Description | Convulxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (4) |
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| Compound Type | - Amide
- Amine
- Animal Toxin
- Natural Compound
- Organic Compound
- Protein
- Snake Venom
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| Protein Structure |  |
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| Synonyms | | Synonym | | CVX | | CVX-alpha | | Snaclec convulxin subunit alpha |
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| Chemical Formula | Not Available |
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| Average Molecular Mass | 18140.725 g/mol |
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| CAS Registry Number | 37206-04-5 |
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| Sequence | Not Available |
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| Chemical Taxonomy |
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| Description | Not Available |
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| Kingdom | Organic Compounds |
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| Super Class | Organic Acids |
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| Class | Carboxylic Acids and Derivatives |
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| Sub Class | Amino Acids, Peptides, and Analogues |
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| Direct Parent | Peptides |
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| Alternative Parents | Not Available |
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| Substituents | Not Available |
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| Molecular Framework | Not Available |
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| External Descriptors | Not Available |
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| Biological Properties |
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| Status | Detected and Not Quantified |
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| Origin | Exogenous |
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| Cellular Locations | Not Available |
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| Biofluid Locations | Not Available |
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| Tissue Locations | Not Available |
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| Pathways | Not Available |
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| Applications | Not Available |
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| Biological Roles | Not Available |
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| Chemical Roles | Not Available |
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| Physical Properties |
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| State | Liquid |
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| Appearance | Clear solution. |
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| Experimental Properties | | Property | Value |
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| Melting Point | Not Available | | Boiling Point | Not Available | | Solubility | >10 mg/mL | | LogP | Not Available |
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| Predicted Properties | Not Available |
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| Spectra |
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| Spectra | | Spectrum Type | Description | Splash Key | Deposition Date | View |
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| Toxicity Profile |
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| Route of Exposure | Injection (sting/bite) (5) |
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| Mechanism of Toxicity | Convulxin binds to the platelet and collagen receptor, glycoprotein VI (GPVI). This causes platelet activation in the blood forming clots and a build up of pressure, which can cause the bloodstream to burst, or the heart or brain to lose blood and result in death. (2) |
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| Metabolism | Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. |
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| Toxicity Values | LD50: 0.262 mg/kg (Intravenous, Mouse) (6)
LD50: 0.216 mg/kg (Intraperitoneal, Mouse) (6) |
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| Lethal Dose | Not Available |
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| Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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| Uses/Sources | Convulxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (4) |
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| Minimum Risk Level | Not Available |
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| Health Effects | Convulxin causes platelet activation in the blood forming clots and a build up of pressure. This can cause the bloodstream to burst, or the heart or brain to lose blood and result in death. (2) |
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| Symptoms | Bites from snakes in the Viperidae family cause local pain, swelling, edema, skin discoloration, and ecchymosis. (1) |
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| Treatment | An antivenom exists for South American rattlesnake venom. (3) |
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| Normal Concentrations |
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| Not Available |
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| Abnormal Concentrations |
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| Not Available |
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| External Links |
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| DrugBank ID | Not Available |
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| HMDB ID | Not Available |
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| PubChem Compound ID | Not Available |
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| ChEMBL ID | Not Available |
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| ChemSpider ID | Not Available |
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| KEGG ID | Not Available |
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| UniProt ID | O93426 |
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| OMIM ID | |
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| ChEBI ID | Not Available |
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| BioCyc ID | Not Available |
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| CTD ID | Not Available |
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| Stitch ID | Not Available |
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| PDB ID | 1UMR |
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| ACToR ID | Not Available |
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| Wikipedia Link | Not Available |
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| References |
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| Synthesis Reference | Not Available |
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| MSDS | Not Available |
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| General References | - Dreisbach, RH (1983). Handbook of Poisoning. Los Altos, California: Lange Medical Publications.
- The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
- Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
- Wikipedia. Convulxin. Last Updated 20 February 2009. [Link]
- Wikipedia. Snake venom. Last Updated 25 July 2009. [Link]
- Thomas S, Griessel E (1999). LD50 Scores for various snakes. [Link]
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| Gene Regulation |
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| Up-Regulated Genes | Not Available |
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| Down-Regulated Genes | Not Available |
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