Prostaglandin D2 receptor 2

NameProstaglandin D2 receptor 2
Synonyms
  • Chemoattractant receptor-homologous molecule expressed on Th2 cells
  • CRTH2
  • DL1R
  • G-protein coupled receptor 44
  • GPR44
Gene NamePTGDR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037246|Prostaglandin D2 receptor 2
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Number of residues395
Molecular Weight43267.15
Theoretical pI10.95
GO Classification
Functions
  • prostaglandin J receptor activity
  • neuropeptide binding
  • G-protein coupled receptor activity
  • prostaglandin D receptor activity
  • prostaglandin F receptor activity
Processes
  • neuropeptide signaling pathway
  • synaptic transmission
  • chemotaxis
  • G-protein coupled receptor signaling pathway
  • calcium-mediated signaling
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • positive regulation of G-protein coupled receptor protein signaling pathway
  • negative regulation of male germ cell proliferation
  • immune response
Components
  • integral component of plasma membrane
  • neuron projection
  • intracellular
  • plasma membrane
General FunctionProstaglandin j receptor activity
Specific FunctionReceptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Pfam Domain Function
Transmembrane Regions34-56 68-89 107-127 147-168 211-231 248-269 289-308
GenBank Protein ID4204216
UniProtKB IDQ9Y5Y4
UniProtKB Entry NamePD2R2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017141|Prostaglandin D2 receptor 2 (PTGDR2)
ATGTCGGCCAACGCCACACTGAAGCCACTCTGCCCCATCCTGGAGCAGATGAGCCGTCTC
CAGAGCCACAGCAACACCAGCATCCGCTACATCGACCACGCGGCCGTGCTGCTGCACGGG
CTGGCCTCGCTGCTGGGCCTGGTGGAGAATGGAGTCATCCTCTTCGTGGTGGGCTGCCGC
ATGCGCCAGACCGTGGTCACCACCTGGGTGCTGCACCTGGCGCTGTCCGACCTGTTGGCC
TCTGCTTCCCTGCCCTTCTTCACCTACTTCTTGGCCGTGGGCCACTCGTGGGAGCTGGGC
ACCACCTTCTGCAAACTGCACTCCTCCATCTTCTTTCTCAACATGTTCGCCAGCGGCTTC
CTGCTCAGCGCCATCAGCCTGGACCGCTGCCTGCAGGTGGTGCGGCCGGTGTGGGCGCAG
AACCACCGCACCGTGGCCGCGGCGCACAAAGTCTGCCTGGTGCTTTGGGCACTAGCGGTG
CTCAACACGGTGCCCTATTTCGTGTTCCGGGACACCATCTCGCGGCTGGACGGGCGCATT
ATGTGCTACTACAATGTGCTGCTCCTGAACCCGGGGCCTGACCGCGATGCCACGTGCAAC
TCGCGGCAGGTGGCCCTGGCCGTCAGCAAGTTCCTGCTGGCCTTCCTGGTGCCGCTGGCG
ATCATCGCCTCGAGCCACGCGGCCGTGAGCCTGCGGTTGCAGCACCGCGGCCGCCGGCGG
CCAGGCCGCTTCGTGCGCCTGGTGGCGGCCGTCGTGGCCGCCTTCGCGCTCTGCTGGGGG
CCCTACCACGTGTTCAGCCTGCTGGAGGCGCGGGCGCACGCAAACCCGGGGCTGCGGCCG
CTCGTGTGGCGCGGGCTGCCCTTCGTCACCAGCCTGGCCTTCTTCAACAGCGTGGCCAAC
CCGGTGCTCTACGTGCTCACCTGCCCCGACATGCTGCGCAAGCTGCGGCGCTCGCTGCGC
ACGGTGCTGGAGAGCGTGCTGGTGGACGACAGCGAGCTGGGTGGCGCGGGAAGCAGCCGC
CGCCGCCGCACCTCCTCCACCGCCCGCTCGGCCTCCCCTTTAGCTCTCTGCAGCCGCCCG
GAGGAACCGCGGGGCCCCGCGCGTCTCCTCGGCTGGCTGCTGGGCAGCTGCGCAGCGTCC
CCGCAGACGGGCCCCCTGAACCGGGCGCTGAGCAGCACCTCGAGTTAG
GenBank Gene IDAB008535
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4502
Chromosome Location11
Locus11q12-q13.3
References
  1. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF: Discovery of three novel orphan G-protein-coupled receptors. Genomics. 1999 Feb 15;56(1):12-21. 10036181
  2. Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, Takano S: Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol. 1999 Feb 1;162(3):1278-86. 9973380
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  5. Monneret G, Gravel S, Diamond M, Rokach J, Powell WS: Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood. 2001 Sep 15;98(6):1942-8. 11535533
  6. Tsuda H, Michimata T, Sakai M, Nagata K, Nakamura M, Saito S: A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy. Clin Exp Immunol. 2001 Jan;123(1):105-11. 11168006
  7. Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, Takamori Y, Ichimasa M, Sugamura K, Nakamura M, Takano S, Nagata K: Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med. 2001 Jan 15;193(2):255-61. 11208866
  8. Sawyer N, Cauchon E, Chateauneuf A, Cruz RP, Nicholson DW, Metters KM, O'Neill GP, Gervais FG: Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. 12466225
  9. Xue L, Gyles SL, Barrow A, Pettipher R: Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). Biochem Pharmacol. 2007 Mar 15;73(6):843-53. Epub 2006 Dec 1. 17196174
  10. Gallant MA, Slipetz D, Hamelin E, Rochdi MD, Talbot S, de Brum-Fernandes AJ, Parent JL: Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. Eur J Pharmacol. 2007 Feb 28;557(2-3):115-23. Epub 2006 Dec 5. 17207480
  11. Roy SJ, Parent A, Gallant MA, de Brum-Fernandes AJ, Stankova J, Parent JL: Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. Eur J Pharmacol. 2010 Mar 25;630(1-3):10-8. doi: 10.1016/j.ejphar.2009.12.022. Epub 2009 Dec 24. 20035740