Calcium-activated chloride channel regulator 2

NameCalcium-activated chloride channel regulator 2
Synonyms
  • 3.4.-.-
  • CaCC-3
  • CACC3
  • Calcium-activated chloride channel family member 2
  • Calcium-activated chloride channel protein 3
  • hCaCC-3
  • hCLCA2
Gene NameCLCA2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019828|Calcium-activated chloride channel regulator 2
MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISN
IKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAH
GDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNND
KPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASI
MFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPP
TFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEI
RAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTS
GDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAF
SRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIIL
FDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNS
AVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDG
AGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGN
IQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEE
LTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFS
PQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDY
LILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
Number of residues943
Molecular Weight103940.01
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • intracellular calcium activated chloride channel activity
  • ligand-gated ion channel activity
  • chloride channel activity
  • metallopeptidase activity
Processes
  • transmembrane transport
  • ion transmembrane transport
  • chloride transmembrane transport
  • transport
  • cell adhesion
Components
  • nucleus
  • plasma membrane
  • cell junction
  • integral component of plasma membrane
  • basal plasma membrane
  • extracellular region
General FunctionMetallopeptidase activity
Specific FunctionPlays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
Pfam Domain Function
Transmembrane Regions902-922
GenBank Protein IDNot Available
UniProtKB IDQ9UQC9
UniProtKB Entry NameCLCA2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019829|Calcium-activated chloride channel regulator 2 (CLCA2)
ATGACCCAAAGGAGCATTGCAGGTCCTATTTGCAACCTGAAGTTTGTGACTCTCCTGGTT
GCCTTAAGTTCAGAACTCCCATTCCTGGGAGCTGGAGTACAGCTTCAAGACAATGGGTAT
AATGGATTGCTCATTGCAATTAATCCTCAGGTACCTGAGAATCAGAACCTCATCTCAAAC
ATTAAGGAAATGATAACTGAAGCTTCATTTTACCTATTTAATGCTACCAAGAGAAGAGTA
TTTTTCAGAAATATAAAGATTTTAATACCTGCCACATGGAAAGCTAATAATAACAGCAAA
ATAAAACAAGAATCATATGAAAAGGCAAATGTCATAGTGACTGACTGGTATGGGGCACAT
GGAGATGATCCATACACCCTACAATACAGAGGGTGTGGAAAAGAGGGAAAATACATTCAT
TTCACACCTAATTTCCTACTGAATGATAACTTAACAGCTGGCTACGGATCACGAGGCCGA
GTGTTTGTCCATGAATGGGCCCACCTCCGTTGGGGTGTGTTCGATGAGTATAACAATGAC
AAACCTTTCTACATAAATGGGCAAAATCAAATTAAAGTGACAAGGTGTTCATCTGACATC
ACAGGCATTTTTGTGTGTGAAAAAGGTCCTTGCCCCCAAGAAAACTGTATTATTAGTAAG
CTTTTTAAAGAAGGATGCACCTTTATCTACAATAGCACCCAAAATGCAACTGCATCAATA
ATGTTCATGCAAAGTTTATCTTCTGTGGTTGAATTTTGTAATGCAAGTACCCACAACCAA
GAAGCACCAAACCTACAGAACCAGATGTGCAGCCTCAGAAGTGCATGGGATGTAATCACA
GACTCTGCTGACTTTCACCACAGCTTTCCCATGAATGGGACTGAGCTTCCACCTCCTCCC
ACATTCTCGCTTGTACAGGCTGGTGACAAAGTGGTCTGTTTAGTGCTGGATGTGTCCAGC
AAGATGGCAGAGGCTGACAGACTCCTTCAACTACAACAAGCCGCAGAATTTTATTTGATG
CAGATTGTTGAAATTCATACCTTCGTGGGCATTGCCAGTTTCGACAGCAAAGGAGAGATC
AGAGCCCAGCTACACCAAATTAACAGCAATGATGATCGAAAGTTGCTGGTTTCATATCTG
CCCACCACTGTATCAGCTAAAACAGACATCAGCATTTGTTCAGGGCTTAAGAAAGGATTT
GAGGTGGTTGAAAAACTGAATGGAAAAGCTTATGGCTCTGTGATGATATTAGTGACCAGC
GGAGATGATAAGCTTCTTGGCAATTGCTTACCCACTGTGCTCAGCAGTGGTTCAACAATT
CACTCCATTGCCCTGGGTTCATCTGCAGCCCCAAATCTGGAGGAATTATCACGTCTTACA
GGAGGTTTAAAGTTCTTTGTTCCAGATATATCAAACTCCAATAGCATGATTGATGCTTTC
AGTAGAATTTCCTCTGGAACTGGAGACATTTTCCAGCAACATATTCAGCTTGAAAGTACA
GGTGAAAATGTCAAACCTCACCATCAATTGAAAAACACAGTGACTGTGGATAATACTGTG
GGCAACGACACTATGTTTCTAGTTACGTGGCAGGCCAGTGGTCCTCCTGAGATTATATTA
TTTGATCCTGATGGACGAAAATACTACACAAATAATTTTATCACCAATCTAACTTTTCGG
ACAGCTAGTCTTTGGATTCCAGGAACAGCTAAGCCTGGGCACTGGACTTACACCCTGAAC
AATACCCATCATTCTCTGCAAGCCCTGAAAGTGACAGTGACCTCTCGCGCCTCCAACTCA
GCTGTGCCCCCAGCCACTGTGGAAGCCTTTGTGGAAAGAGACAGCCTCCATTTTCCTCAT
CCTGTGATGATTTATGCCAATGTGAAACAGGGATTTTATCCCATTCTTAATGCCACTGTC
ACTGCCACAGTTGAGCCAGAGACTGGAGATCCTGTTACGCTGAGACTCCTTGATGATGGA
GCAGGTGCTGATGTTATAAAAAATGATGGAATTTACTCGAGGTATTTTTTCTCCTTTGCT
GCAAATGGTAGATATAGCTTGAAAGTGCATGTCAATCACTCTCCCAGCATAAGCACCCCA
GCCCACTCTATTCCAGGGAGTCATGCTATGTATGTACCAGGTTACACAGCAAACGGTAAT
ATTCAGATGAATGCTCCAAGGAAATCAGTAGGCAGAAATGAGGAGGAGCGAAAGTGGGGC
TTTAGCCGAGTCAGCTCAGGAGGCTCCTTTTCAGTGCTGGGAGTTCCAGCTGGCCCCCAC
CCTGATGTGTTTCCACCATGCAAAATTATTGACCTGGAAGCTGTAAAAGTAGAAGAGGAA
TTGACCCTATCTTGGACAGCACCTGGAGAAGACTTTGATCAGGGCCAGGCTACAAGCTAT
GAAATAAGAATGAGTAAAAGTCTACAGAATATCCAAGATGACTTTAACAATGCTATTTTA
GTAAATACATCAAAGCGAAATCCTCAGCAAGCTGGCATCAGGGAGATATTTACGTTCTCA
CCCCAAATTTCCACGAATGGACCTGAACATCAGCCAAATGGAGAAACACATGAAAGCCAC
AGAATTTATGTTGCAATACGAGCAATGGATAGGAACTCCTTACAGTCTGCTGTATCTAAC
ATTGCCCAGGCGCCTCTGTTTATTCCCCCCAATTCTGATCCTGTACCTGCCAGAGATTAT
CTTATATTGAAAGGAGTTTTAACAGCAATGGGTTTGATAGGAATCATTTGCCTTATTATA
GTTGTGACACATCATACTTTAAGCAGGAAAAAGAGAGCAGACAAGAAAGAGAATGGAACA
AAATTATTATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2016
Chromosome Location1
LocusNot Available
References
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