Rho-related GTP-binding protein RhoF

NameRho-related GTP-binding protein RhoF
Synonyms
  • ARHF
  • Rho family GTPase Rif
  • Rho in filopodia
  • RIF
Gene NameRHOF
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009109|Rho-related GTP-binding protein RhoF
MDAPGALAQTAAPGPGRKELKIVIVGDGGCGKTSLLMVYSQGSFPEHYAPSVFEKYTASV
TVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMNPTSYDNVLIKWFPEVTHF
CRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLSACEQIRAALYLECSAKFREN
VEDVFREAAKVALSALKKAQRQKKRRLCLLL
Number of residues211
Molecular Weight23625.22
Theoretical pINot Available
GO Classification
Functions
  • GTP binding
  • GTPase activity
Processes
  • small GTPase mediated signal transduction
  • actin filament organization
  • regulation of small GTPase mediated signal transduction
Components
  • cytosol
  • extracellular exosome
  • cytoskeleton
  • plasma membrane
General FunctionGtpase activity
Specific FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9HBH0
UniProtKB Entry NameRHOF_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013618|Rho-related GTP-binding protein RhoF (RHOF)
ATGGATGCCCCCGGGGCCCTGGCCCAGACCGCCGCCCCCGGTCCGGGCAGGAAGGAGCTG
AAGATCGTGATCGTGGGCGACGGCGGCTGCGGCAAGACCTCGCTGCTCATGGTGTACAGC
CAGGGCTCCTTCCCCGAGCACTACGCCCCATCGGTGTTCGAGAAGTACACGGCCAGCGTG
ACCGTTGGCAGCAAGGAGGTGACCCTGAACCTCTACGACACGGCCGGGCAAGAAGACTAT
GACCGGCTGCGGCCCCTGTCCTACCAGAACACCCACCTCGTGCTCATCTGCTATGACGTC
ATGAATCCCACCAGCTACGACAACGTCCTCATCAAGTGGTTCCCTGAGGTCACGCATTTC
TGCCGCGGGATCCCCATGGTGCTCATCGGCTGCAAGACAGACCTGAGGAAGGACAAGGAG
CAGCTGCGGAAGCTCCGGGCCGCCCAGCTGGAGCCCATCACCTACATGCAGGGCCTGAGC
GCCTGCGAACAGATCCGAGCTGCTCTCTACCTGGAATGTTCCGCCAAGTTTCGGGAGAAT
GTGGAGGACGTCTTCCGGGAGGCCGCCAAGGTGGCTCTCAGCGCTCTGAAGAAGGCGCAA
CGGCAGAAGAAGCGCCGGCTCTGCCTGCTGCTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:15703
Chromosome Location12
LocusNot Available
References
  1. Ellis S, Mellor H: The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. Curr Biol. 2000 Nov 2;10(21):1387-90. 11084341
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