Cytochrome P450 3A43

NameCytochrome P450 3A43
Synonyms
  • 1.14.14.1
Gene NameCYP3A43
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006840|Cytochrome P450 3A43
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
PILQPEKPIVLKVHLRDGITSGP
Number of residues503
Molecular Weight57669.21
Theoretical pI8.25
GO Classification
Functions
  • aromatase activity
  • iron ion binding
  • heme binding
  • monooxygenase activity
Processes
  • small molecule metabolic process
  • xenobiotic metabolic process
Components
  • endoplasmic reticulum membrane
General FunctionMonooxygenase activity
Specific FunctionExhibits low testosterone 6-beta-hydroxylase activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID12642642
UniProtKB IDQ9HB55
UniProtKB Entry NameCP343_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0012469|Cytochrome P450 3A43 (CYP3A43)
ATGGATCTCATTCCAAACTTTGCCATGGAAACATGGGTTCTTGTGGCTACCAGCCTGGTA
CTCCTCTATATTTATGGGACCCATTCACATAAACTTTTTAAGAAGCTGGGAATTCCTGGG
CCAACCCCTCTGCCTTTTCTGGGAACTATTTTGTTCTACCTTAGGAGGTCTCTGAATAAG
ATTCCCAGCTGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGCA
GGAGGATCACCTAAGGTCAGGAGTTCGAGACCAGCTTTGCCAACATGGGTCTTTGGAATT
TTGACAGAGAATGTAATGAAAAATACGGAGAAATGTGGGGCACTCTTTCCATTTCTTACC
CCAGTTTTTGAAGCCCTAAATATCGGTTTGTTTCCAAAAGATGTTACCCATTTTTTAAAA
AATTCCATTGAAAGGATGAAAGAAAGTCGCCTCAAAGATAAACAAAAGCATCGAGTAGAT
TTCTTTCAACAGATGATCGACTCCCAGAATTCCAAAGAAACAAAGTCCCATAAAGCTCTG
TCTGATCTGGAGCTTGTGGCCCAGTCAATTATCATCATTTTTGCTGCCTATGACACAACT
AGCACCACTCTCCCCTTCATTATGTATGAACTGGCCACTCACCCTGATGTCCAGCAGAAA
CTGCAGGAGGAGATTGACGCAGTTTTACCCAATAAGGCACCTGTCACCTACGATGCCCTG
GTACAGATGGAGTACCTTGACATGGTGGTGAATGAAACGCTCAGATTATTCCCAGTTGTT
AGTAGAGTTACGAGAGTCTGCAAGAAAGATATTGAAATCAATGGAGTGTTCATTCCCAAA
GGGTTAGCAGTGATGGTTCCAATCTATGCTCTTCACCATGACCCAAAGTACTGGACAGAG
CCTGAGAAGTTCTGCCCTGAAAGGTTCAGTAAGAAGAACAAGGACAGCATAGATCTTTAC
AGATACATACCTTTTGGAGCTGGACCCCGAAACTGCATTGGCATGAGGTTTGCTCTCACA
AACATAAAACTTGCTGTCATTAGAGCACTGCAGAACTTCTCCTTCAAACCTTGTAAAGAG
ACTCAGATCCCACTGAAATTAGACAATCTACCAATTCTTCAACCAGAAAAACCTATTGTT
CTAAAAGTGCACTTAAGAGATGGGATTACAAGTGGACCCTGA
GenBank Gene IDAF319634
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17450
Chromosome Location7
Locus7q21.1
References
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  4. Cauffiez C, Lo-Guidice JM, Chevalier D, Allorge D, Hamdan R, Lhermitte M, Lafitte JJ, Colombel JF, Libersa C, Broly F: First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. Hum Mutat. 2004 Jan;23(1):101. 14695544
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