Sodium-coupled neutral amino acid transporter 1

NameSodium-coupled neutral amino acid transporter 1
Synonyms
  • Amino acid transporter A1
  • ATA1
  • N-system amino acid transporter 2
  • NAT2
  • SAT1
  • SNAT1
  • Solute carrier family 38 member 1
  • System A amino acid transporter 1
  • System N amino acid transporter 1
Gene NameSLC38A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009840|Sodium-coupled neutral amino acid transporter 1
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEK
KKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSIN
LLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFL
MGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKK
FQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELK
DRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAV
IVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGV
VGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACS
SSSDEGH
Number of residues487
Molecular Weight54047.02
Theoretical pINot Available
GO Classification
Functions
  • sodium
  • neutral amino acid transmembrane transporter activity
  • amino acid transmembrane transporter activity
Processes
  • transmembrane transport
  • neutral amino acid transport
  • amino acid transmembrane transport
  • neurotransmitter uptake
  • ion transport
  • amino acid transport
  • synaptic transmission
Components
  • integral component of membrane
  • extracellular exosome
  • integral component of plasma membrane
  • plasma membrane
General FunctionSodium:amino acid symporter activity
Specific FunctionFunctions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
Pfam Domain Function
Transmembrane Regions75-97 113-133 148-168 189-211 217-237 276-296 313-333 351-371 394-414 417-437 453-473
GenBank Protein IDNot Available
UniProtKB IDQ9H2H9
UniProtKB Entry NameS38A1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013942|Sodium-coupled neutral amino acid transporter 1 (SLC38A1)
ATGATGCATTTCAAAAGTGGACTCGAATTAACTGAGTTGCAAAACATGACAGTGCCCGAG
GATGATAACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAAT
AGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCACAAACAGCCATTTGGAAAAA
AAGAAGTGTGATGAGTATATTCCAGGTACAACCTCCTTAGGCATGTCTGTTTTTAACCTA
AGCAACGCCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGA
ATCCTACTTTTTCTGGTACTTTTGACTTCAGTGACATTGCTGTCTATATATTCAATAAAC
CTCCTATTGATCTGTTCAAAAGAAACAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAA
GTCTTTGGCACCACAGGGAAGTTCGTAATCTTTGGAGCCACCTCTCTACAGAACACTGGA
GCAATGCTGAGCTACCTCTTCATCGTAAAAAATGAACTACCCTCTGCCATAAAGTTTCTA
ATGGGAAAGGAAGAGACATTTTCAGCCTGGTACGTGGATGGCCGCGTTCTGGTGGTGATA
GTTACCTTTGGCATAATTCTCCCTCTGTGTCTCTTGAAGAACTTAGGGTATCTTGGCTAT
ACTAGTGGATTTTCCTTGAGCTGTATGGTTTTTTTCCTAATTGTGGTTATTTACAAGAAA
TTTCAAATTCCCTGCATTGTTCCAGAGCTAAATTCAACAATAAGTGCTAATTCAACAAAT
GCTGACACGTGTACGCCAAAATATGTTACCTTCAATTCAAAGACCGTGTATGCTTTACCC
ACCATTGCATTTGCATTTGTTTGCCACCCGTCAGTCCTGCCAATTTACAGTGAGCTTAAA
GACCGATCACAGAAAAAAATGCAGATGGTTTCAAACATCTCCTTTTTCGCCATGTTTGTT
ATGTACTTCTTGACTGCCATTTTTGGCTACTTGACATTCTATGACAACGTGCAGTCCGAC
CTCCTTCACAAATATCAGAGTAAAGATGACATTCTCATCCTGACAGTGCGGCTGGCTGTC
ATTGTTGCTGTGATCCTCACAGTGCCGGTGTTATTTTTCACGGTTCGTTCATCTTTATTT
GAACTGGCTAAGAAAACAAAGTTTAATTTATGTCGTCATACCGTGGTTACCTGCATACTC
TTGGTTGTTATCAACTTGTTGGTGATCTTCATACCCTCCATGAAGGATATTTTTGGAGTC
GTAGGAGTTACATCTGCTAACATGCTTATTTTCATTCTTCCTTCATCTCTTTATTTAAAA
ATCACAGACCAGGATGGAGATAAAGGAACTCAAAGAATTTGGGCTGCCCTTTTCTTGGGC
CTGGGGGTGTTGTTCTCCTTGGTCAGCATTCCCTTGGTCATCTATGACTGGGCCTGCTCA
TCGAGTAGTGACGAAGGCCACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13447
Chromosome Location12
LocusNot Available
References
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