Rho-related GTP-binding protein RhoV

NameRho-related GTP-binding protein RhoV
Synonyms
  • ARHV
  • CDC42-like GTPase 2
  • GTP-binding protein-like 2
  • Rho GTPase-like protein ARHV
  • Wnt-1 responsive Cdc42 homolog 2
  • WRCH-2
  • WRCH2
Gene NameRHOV
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013609|Rho-related GTP-binding protein RhoV
MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARY
RPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQN
ITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRA
CCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV
Number of residues236
Molecular Weight26216.915
Theoretical pINot Available
GO Classification
Functions
  • GTP binding
  • metal ion binding
Processes
  • small GTPase mediated signal transduction
  • regulation of small GTPase mediated signal transduction
Components
  • plasma membrane
  • cytosol
  • endosome membrane
General FunctionMetal ion binding
Specific FunctionPlays a role in the control of the actin cytoskeleton via activation of the JNK pathway.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ96L33
UniProtKB Entry NameRHOV_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013610|Rho-related GTP-binding protein RhoV (RHOV)
ATGCCGCCGCGGGAGCTGAGCGAGGCCGAGCCGCCCCCGCTCCGGGCCCCGACCCCTCCC
CCGCGGCGGCGTAGCGCGCCCCCAGAGCTGGGCATCAAGTGCGTGCTGGTGGGCGACGGC
GCCGTGGGCAAGAGCAGCCTCATCGTCAGCTACACCTGCAATGGGTACCCCGCGCGCTAC
CGGCCCACTGCGCTGGACACCTTCTCTGTGCAAGTCCTGGTGGATGGAGCTCCGGTGCGC
ATTGAGCTCTGGGACACAGCGGGACAGGAGGATTTTGACCGACTTCGTTCCCTTTGCTAC
CCGGATACCGATGTCTTCCTGGCGTGCTTCAGCGTGGTGCAGCCCAGCTCCTTTCAAAAC
ATCACAGAGAAATGGCTGCCCGAGATCCGCACGCACAACCCCCAGGCGCCTGTGCTGCTG
GTGGGCACCCAGGCCGACCTGAGGGACGATGTCAACGTACTAATTCAGCTGGACCAGGGG
GGCCGGGAGGGCCCCGTGCCCCAACCCCAGGCTCAGGGTCTGGCCGAGAAGATCCGAGCC
TGCTGCTACCTTGAGTGCTCAGCCTTGACGCAGAAGAACTTGAAGGAAGTATTTGACTCG
GCTATTCTCAGTGCCATTGAGCACAAAGCCCGGCTGGAGAAGAAACTGAATGCCAAAGGT
GTGCGCACCCTCTCCCGCTGCCGCTGGAAGAAGTTCTTCTGCTTCGTTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:18313
Chromosome Location15
LocusNot Available
References
  1. Katoh M: Molecular cloning and characterization of WRCH2 on human chromosome 15q15. Int J Oncol. 2002 May;20(5):977-82. 11956592
  2. Wherlock M, Mellor H: The Rho GTPase family: a Racs to Wrchs story. J Cell Sci. 2002 Jan 15;115(Pt 2):239-40. 11839775
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334