Receptor-type tyrosine-protein phosphatase U

NameReceptor-type tyrosine-protein phosphatase U
Synonyms
  • 3.1.3.48
  • FMI
  • hPTP-J
  • Pancreatic carcinoma phosphatase 2
  • PCP-2
  • PCP2
  • Protein-tyrosine phosphatase J
  • Protein-tyrosine phosphatase pi
  • Protein-tyrosine phosphatase receptor omicron
  • PTP pi
  • PTP-J
  • PTP-RO
  • PTPRO
  • R-PTP-psi
  • R-PTP-U
  • Receptor-type protein-tyrosine phosphatase psi
Gene NamePTPRU
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008993|Receptor-type tyrosine-protein phosphatase U
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS
YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
EGLESR
Number of residues1446
Molecular Weight162422.095
Theoretical pINot Available
GO Classification
Functions
  • beta-catenin binding
  • transmembrane receptor protein tyrosine phosphatase activity
  • protein tyrosine phosphatase activity
Processes
  • single organismal cell-cell adhesion
  • peptidyl-tyrosine dephosphorylation
  • canonical Wnt signaling pathway
  • protein localization to cell surface
  • cell adhesion
  • transmembrane receptor protein tyrosine phosphatase signaling pathway
  • homotypic cell-cell adhesion
  • cell differentiation
  • negative regulation of cell proliferation
  • response to glucocorticoid
  • negative regulation of cell migration
  • protein dephosphorylation
  • organ regeneration
Components
  • plasma membrane
  • integral component of plasma membrane
  • cell-cell junction
General FunctionTransmembrane receptor protein tyrosine phosphatase activity
Specific FunctionTyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Pfam Domain Function
Transmembrane Regions750-770
GenBank Protein IDNot Available
UniProtKB IDQ92729
UniProtKB Entry NamePTPRU_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0013553|Receptor-type tyrosine-protein phosphatase U (PTPRU)
ATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACC
GAGACTCCGGCAGCTGGCTGCACCTTCGAGGAGGCAAGTGACCCAGCAGTGCCCTGCGAG
TACAGCCAGGCCCAGTACGATGACTTCCAGTGGGAGCAAGTGCGAATCCACCCTGGCACC
CGGGCACCTGCGGACCTGCCCCACGGCTCCTACTTGATGGTCAACACTTCCCAGCATGCC
CCAGGCCAGCGAGCCCATGTCATCTTCCAGAGCCTGAGCGAGAATGATACCCACTGTGTG
CAGTTCAGCTACTTCCTGTACAGCCGGGACGGGCACAGCCCGGGCACCCTGGGCGTCTAC
GTGCGCGTTAATGGGGGCCCCCTGGGCAGTGCTGTGTGGAATATGACTGGATCCCACGGC
CGTCAGTGGCACCAGGCTGAGCTGGCTGTCAGCACTTTCTGGCCCAATGAATATCAGGTG
CTGTTTGAGGCCCTCATCTCCCCAGACCGCAGGGGCTACATGGGCCTAGATGACATCCTG
CTTCTCAGCTACCCCTGCGCAAAGGCCCCACACTTCTCCCGCCTGGGCGACGTGGAGGTC
AACGCGGGCCAGAACGCGTCGTTCCAGTGCATGGCCGCGGGCAGAGCGGCCGAGGCCGAA
CGCTTCCTCTTGCAACGGCAGAGCGGGGCGCTGGTGCCGGCGGCGGGCGTGCGGCACATC
AGCCACCGGCGCTTCCTGGCCACTTTCCCGCTGGCTGCCGTGAGCCGCGCCGAGCAGGAC
CTGTACCGCTGTGTGTCCCAGGCCCCGCGCGGCGCGGGCGTCTCTAACTTCGCGGAGCTC
ATCGTCAAGGAGCCCCCAACTCCCATCGCGCCCCCACAGCTGCTGCGTGCTGGCCCCACC
TACCTCATCATCCAGCTCAACACCAACTCCATCATTGGCGACGGGCCGATCGTGCGCAAG
GAGATTGAGTACCGCATGGCGCGCGGGCCCTGGGCTGAGGTGCACGCCGTCAGCCTGCAG
ACCTACAAGCTGTGGCACCTCGACCCCGACACAGAGTATGAGATCAGCGTGCTGCTCACG
CGTCCCGGAGACGGCGGCACTGGCCGCCCTGGGCCACCCCTCATCAGCCGCACCAAATGC
GCAGAGCCCATGAGGGCCCCCAAAGGCCTGGCTTTTGCTGAGATCCAGGCCCGTCAGCTG
ACCCTGCAGTGGGAACCACTGGGCTACAACGTGACGCGTTGCCACACCTATACTGTGTCG
CTGTGCTATCACTACACCCTGGGCAGCAGCCACAACCAGACCATCCGAGAGTGTGTGAAG
ACAGAGCAAGGTGTCAGCCGCTACACCATCAAGAACCTGCTGCCCTATCGGAACGTTCAC
GTGAGGCTTGTCCTCACTAACCCTGAGGGGCGCAAAGAGGGCAAGGAGGTCACTTTCCAG
ACGGATGAGGATGTGCCCAGTGGGATTGCAGCCGAGTCCCTGACCTTCACTCCACTGGAG
GACATGATCTTCCTCAAGTGGGAGGAGCCCCAGGAGCCCAATGGTCTCATCACCCAGTAT
GAGATCAGCTACCAGAGCATCGAGTCATCAGACCCGGCAGTGAACGTGCCAGGCCCACGA
CGTACCATCTCCAAGCTCCGCAATGAGACCTACCATGTCTTCTCCAACCTGCACCCAGGC
ACCACCTACCTGTTCTCCGTGCGGGCCCGCACAGGCAAAGGCTTCGGCCAGGCGGCACTC
ACTGAGATAACCACTAACATCTCTGCTCCCAGCTTTGATTATGCCGACATGCCGTCACCC
CTGGGCGAGTCTGAGAACACCATCACCGTGCTGCTGAGGCCGGCACAGGGCCGCGGTGCG
CCCATCAGTGTGTACCAGGTGATTGTGGAGGAGGAGCGGGCGCGGAGGCTGCGGCGGGAG
CCAGGTGGACAGGACTGCTTCCCAGTGCCATTGACCTTCGAGGCGGCGCTGGCCCGAGGC
CTGGTGCACTACTTCGGGGCCGAACTGGCGGCCAGCAGTCTACCTGAGGCCATGCCCTTT
ACCGTGGGTGACAACCAGACCTACCGAGGCTTCTGGAACCCACCACTTGAGCCTAGGAAG
GCCTATCTCATCTACTTCCAGGCAGCAAGCCACCTGAAGGGGGAGACCCGGCTGAATTGC
ATCCGCATTGCCAGGAAAGCTGCCTGCAAGGAAAGCAAGCGGCCCCTGGAGGTGTCCCAG
AGATCGGAGGAGATGGGGCTTATCCTGGGCATCTGTGCAGGGGGGCTTGCTGTCCTCATC
CTTCTCCTGGGTGCCATCATTGTCATCATCCGCAAAGGGAAGCCGGTGAACATGACCAAG
GCCACCGTCAACTACCGCCAGGAGAAGACACACATGATGAGCGCCGTGGACCGCAGCTTC
ACAGACCAGAGCACCCTGCAGGAGGACGAGCGGCTGGGCCTGTCCTTCATGGACACCCAT
GGCTACAGCACCCGGGGAGACCAGCGCAGCGGTGGGGTCACTGAGGCCAGCAGCCTCCTG
GGGGGCTCCCCGAGGCGTCCCTGTGGCCGGAAGGGCTCCCCATACCACACGGGGCAGCTG
CACCCTGCGGTGCGTGTCGCAGACCTTCTGCAGCACATCAACCAGATGAAGACGGCCGAG
GGTTACGGCTTCAAGCAGGAGTATGAGAGCTTCTTTGAAGGCTGGGACGCCACAAAGAAG
AAAGACAAGGTCAAGGGCAGCCGGCAGGAGCCAATGCCTGCCTATGATCGGCACCGAGTG
AAACTGCACCCGATGCTGGGAGACCCCAATGCCGACTACATTAATGCCAACTACATAGAT
GGTTACCACAGGTCAAACCACTTCATAGCCACTCAAGGGCCGAAGCCTGAGATGGTCTAT
GACTTCTGGCGTATGGTGTGGCAGGAGCACTGTTCCAGCATCGTCATGATCACCAAGCTG
GTCGAGGTGAAATGCTCACGGTACTGGCCGGAGGACTCAGACACCTACGGGGACATCAAG
ATTATGCTGGTGAAGACAGAGACCCTGGCTGAGTATGTCGTGCGCACTTTTGCCCTGGAG
CGGAGAGGCTACTCTGCCCGGCACGAGGTCCGCCAGTTCCACTTCACAGCGTGGCCAGAG
CATGGCGTCCCCTACCATGCCACGGGGCTGCTGGCTTTCATCCGGCGCGTGAAGGCCTCC
ACCCCACCTGATGCCGGGCCCATTGTCATCCACTGCAGCGCGGGCACCGGCCGCACAGGT
TGCTATATCGTCCTGGATGTGATGCTGGACATGGCAGAGTGTGAGGGCGTCGTGGACATT
TACAACTGTGTGAAGACTCTCTGCTCCCGGCGTGTCAACATGATCCAGACTGAGGAGCAG
TACATCTTCATTCATGATGCAATCCTGGAGGCCTGCCTGTGTGGGGAGACCACCATCCCT
GTCAGTGAGTTCAAGGCCACCTACAAGGAGATGATCCGCATTGATCCTCAGAGTAATTCC
TCCCAGCTGCGGGAAGAGTTCCAGACGCTGAACTCGGTCACCCCGCCGCTGGACGTGGAG
GAGTGCAGCATCGCCCTGTTGCCCCGGAACCGCGACAAGAACCGCAGCATGGACGTCCTG
CCGCCCGACCGCTGCCTGCCCTTCCTCATCTCCACTGATGGGGACTCCAACAACTACATT
AATGCAGCCCTGACTGACAGCTACACACGGAGTGCGGCCTTCATCGTGACCCTGCACCCG
CTGCAGAGCACCACGCCCGACTTCTGGCGGCTGGTCTACGATTACGGGTGCACCTCCATC
GTCATGCTCAACCAGCTGAACCAGTCCAACTCCGCCTGGCCCTGCCTGCAGTACTGGCCA
GAGCCAGGCCGGCAGCAATATGGCCTCATGGAGGTGGAGTTTATGTCGGGCACAGCTGAT
GAAGACTTAGTGGCTCGAGTCTTCCGGGTGCAGAACATCTCTCGGTTGCAGGAGGGGCAC
CTGCTGGTGCGGCACTTCCAGTTCCTGCGCTGGTCTGCATACCGGGACACACCTGACTCC
AAGAAGGCCTTCTTGCACCTGCTGGCTGAGGTGGACAAGTGGCAGGCCGAGAGTGGGGAT
GGGCGCACCATCGTGCACTGCCTAAACGGGGGAGGACGCAGCGGCACCTTCTGCGCCTGC
GCCACGGTCCTGGAGATGATCCGCTGCCACAACTTGGTGGACGTTTTCTTTGCTGCCAAA
ACCCTCCGGAACTACAAACCCAACATGGTGGAGACCATGGATCAGTACCACTTTTGCTAC
GATGTGGCCCTGGAGTACTTGGAGGGGCTGGAGTCAAGATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9683
Chromosome Location1
LocusNot Available
References
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