Carnitine O-palmitoyltransferase 1, muscle isoform

NameCarnitine O-palmitoyltransferase 1, muscle isoform
Synonyms
  • 2.3.1.21
  • Carnitine O-palmitoyltransferase I, muscle isoform
  • Carnitine palmitoyltransferase 1B
  • Carnitine palmitoyltransferase I-like protein
  • CPT I
  • CPT1-M
  • CPTI-M
  • KIAA1670
Gene NameCPT1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009816|Carnitine O-palmitoyltransferase 1, muscle isoform
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPT
SWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTG
IFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPR
VSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEE
YIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALG
IVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDL
EMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA
LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPI
IGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKAL
ADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREG
RTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCL
YLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGY
GVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS
Number of residues772
Molecular Weight87800.385
Theoretical pINot Available
GO Classification
Functions
  • carnitine O-palmitoyltransferase activity
Processes
  • fatty acid beta-oxidation
  • small molecule metabolic process
  • cellular lipid metabolic process
  • carnitine shuttle
Components
  • mitochondrion
  • mitochondrial outer membrane
  • integral component of membrane
General FunctionCarnitine o-palmitoyltransferase activity
Specific FunctionNot Available
Pfam Domain Function
Transmembrane Regions48-73 103-122
GenBank Protein IDNot Available
UniProtKB IDQ92523
UniProtKB Entry NameCPT1B_HUMAN
Cellular LocationMitochondrion outer membrane
Gene sequence
>lcl|BSEQ0013932|Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B)
ATGGCGGAAGCTCACCAGGCCGTGGCCTTCCAGTTCACGGTGACCCCAGACGGGGTCGAC
TTCCGGCTCAGTCGGGAGGCCCTGAAACACGTCTACCTGTCTGGGATCAACTCCTGGAAG
AAACGCCTGATCCGCATCAAGAATGGCATCCTCAGGGGCGTGTACCCTGGCAGCCCCACC
AGCTGGCTGGTCGTCATCATGGCAACAGTGGGTTCCTCCTTCTGCAACGTGGACATCTCC
TTGGGGCTGGTCAGTTGCATCCAGAGATGCCTCCCTCAGGGGTGTGGCCCCTACCAGACC
CCGCAGACCCGGGCACTTCTCAGCATGGCCATCTTCTCCACGGGCGTCTGGGTGACGGGC
ATCTTCTTCTTCCGCCAAACCCTGAAGCTGCTTCTCTGCTACCATGGGTGGATGTTTGAG
ATGCATGGCAAGACCAGCAACTTGACCAGGATCTGGGCTTACCTAGAGTCTGTGCGCCCC
TTGTTGGATGATGAGGAATATTACCGCATGGAGTTGCTGGCCAAAGAATTCCAGGACAAG
ACTGCCCCCAGGCTGCAGAAATACCTGGTGCTCAAGTCATGGTGGGCAAGTAACTATGTG
AGTGACTGGTGGGAAGAGTACATCTACCTTCGAGGCAGGAGCCCTCTCATGGTGAACAGC
AACTATTATGTCATGGACCTTGTGCTCATCAAGAATACAGACGTGCAGGCAGCCCGCCTG
GGAAACATCATCCACGCCATGATCATGTATCGCCGTAAACTGGACCGTGAAGAAATCAAG
CCTGTGATGGCACTGGGCATAGTGCCTATGTGCTCCTACCAGATGGAGAGGATGTTCAAC
ACCACTCGGATCCCGGGCAAGGACACAGATGTGCTACAGCACCTCTCAGACAGCCGGCAC
GTGGCTGTCTACCACAAGGGACGCTTCTTCAAGCTGTGGCTCTATGAGGGCGCCCGTCTG
CTCAAGCCTCAGGATCTGGAGATGCAGTTCCAGAGGATCCTGGACGACCCCTCCCCACCT
CAGCCTGGGGAGGAGAAGCTGGCAGCCCTCACTGCAGGAGGAAGGGTGGAGTGGGCGCAG
GCACGCCAGGCCTTCTTTAGCTCTGGAAAGAATAAGGCTGCCTTGGAGGCCATCGAGCGT
GCCGCTTTCTTCGTGGCCCTGGATGAGGAATCCTACTCCTATGACCCCGAAGATGAGGCC
AGCCTCAGCCTCTATGGCAAGGCCCTGCTACATGGCAACTGCTACAACAGGTGGTTTGAC
AAATCCTTCACTCTCATTTCCTTCAAGAATGGCCAGTTGGGTCTCAATGCAGAGCATGCG
TGGGCAGATGCTCCCATCATTGGGCACCTCTGGGAGTTTGTCCTGGGCACAGACAGCTTC
CACCTGGGCTACACGGAGACCGGGCACTGCCTGGGCAAACCGAACCCTGCGCTCGCACCT
CCTACACGGCTGCAGTGGGACATTCCAAAACAGTGCCAGGCGGTCATCGAGAGTTCCTAC
CAGGTGGCCAAGGCGTTGGCAGACGACGTGGAGTTGTACTGCTTCCAGTTCCTGCCCTTT
GGCAAAGGCCTCATCAAGAAGTGCCGGACCAGCCCTGATGCCTTTGTGCAGATCGCGCTG
CAGCTGGCTCACTTCCGGGACAGGGGTAAGTTCTGCCTGACCTATGAGGCCTCAATGACC
AGAATGTTCCGGGAGGGACGGACTGAGACTGTGCGTTCCTGTACCAGCGAGTCCACAGCC
TTTGTGCAGGCCATGATGGAGGGGTCCCACACAAAAGCAGACCTGCGAGATCTCTTCCAG
AAGGCTGCTAAGAAGCACCAGAATATGTACCGCCTGGCCATGACCGGGGCAGGGATCGAC
AGGCACCTCTTCTGCCTTTACTTGGTCTCCAAGTACCTAGGAGTCAGCTCTCCTTTCCTT
GCTGAGGTGCTCTCGGAACCCTGGCGTCTCTCCACCAGCCAGATCCCCCAATCCCAGATC
CGCATGTTCGACCCAGAGCAGCACCCCAATCACCTGGGCGCTGGAGGTGGCTTTGGCCCT
GTAGCAGATGATGGCTATGGAGTTTCCTACATGATTGCAGGCGAGAACACGATCTTCTTC
CACATCTCCAGCAAGTTCTCAAGCTCAGAGACGAACGCCCAGCGCTTTGGAAACCACATC
CGCAAAGCCCTGCTGGACATTGCTGATCTTTTCCAAGTTCCCAAGGCCTACAGCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2329
Chromosome Location22
LocusNot Available
References
  1. Yamazaki N, Shinohara Y, Shima A, Yamanaka Y, Terada H: Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta. 1996 Jun 7;1307(2):157-61. 8679700
  2. Zhu H, Shi J, de Vries Y, Arvidson DN, Cregg JM, Woldegiorgis G: Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I. Arch Biochem Biophys. 1997 Nov 1;347(1):53-61. 9344464
  3. Britton CH, Mackey DW, Esser V, Foster DW, Burns DK, Yarnall DP, Froguel P, McGarry JD: Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). Genomics. 1997 Feb 15;40(1):209-11. 9070950
  4. van der Leij FR, Takens J, van der Veen AY, Terpstra P, Kuipers JR: Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta. 1997 May 30;1352(2):123-8. 9199240
  5. Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H: Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I. FEBS Lett. 1997 Jun 16;409(3):401-6. 9224698
  6. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O: Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. DNA Res. 2001 Feb 28;8(1):1-9. 11258795
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