T3DB: Kinesin-like protein KIF18A

Name	Kinesin-like protein KIF18A
Synonyms	Marrow stromal KIF18A MS-KIF18A
Gene Name	KIF18A
Organism	Human
Amino acid sequence	>lcl\|BSEQ0017699\|Kinesin-like protein KIF18A MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
Number of residues	898
Molecular Weight	102280.305
Theoretical pI	Not Available
GO Classification	Functions microtubule plus-end binding tubulin-dependent ATPase activity ubiquitin binding microtubule binding ATP binding ATP-dependent microtubule motor activity, plus-end-directed actin binding Processes mitotic sister chromatid segregation antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic cell cycle seminiferous tubule development microtubule-based movement blood coagulation mitotic metaphase plate congression microtubule depolymerization protein transport regulation of microtubule cytoskeleton organization small GTPase mediated signal transduction male meiosis Components cytosol kinetochore microtubule caveola microtubule organizing center cytoplasm ruffle kinesin complex microtubule cytoskeleton kinetochore mitotic spindle midzone nucleus
General Function	Ubiquitin binding
Specific Function	Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q8NI77
UniProtKB Entry Name	KI18A_HUMAN
Cellular Location	Cell projection
Gene sequence	>lcl\|BSEQ0017700\|Kinesin-like protein KIF18A (KIF18A) ATGTCTGTCACTGAGGAAGACCTGTGCCACCATATGAAAGTAGTAGTTCGTGTACGTCCG GAAAACACTAAAGAAAAAGCAGCTGGATTTCATAAAGTGGTTCATGTTGTGGATAAACAT ATCCTAGTTTTTGATCCCAAACAAGAAGAAGTCAGTTTTTTCCATGGAAAGAAAACTACA AATCAAAATGTTATAAAGAAACAAAATAAGGATCTTAAATTTGTATTTGATGCTGTTTTT GATGAAACGTCAACTCAGTCAGAAGTTTTTGAACACACTACTAAGCCAATTCTTCGTAGT TTTTTGAATGGATATAATTGCACAGTACTTGCCTATGGTGCCACTGGTGCTGGGAAGACC CACACTATGCTAGGATCAGCTGATGAACCTGGAGTGATGTATCTAACAATGTTACACCTT TACAAATGCATGGATGAGATTAAAGAAGAGAAAATATGTAGTACTGCAGTTTCATATCTG GAGGTATATAATGAACAGATTCGTGATCTCTTAGTAAATTCAGGGCCACTTGCTGTCCGG GAAGATACCCAAAAAGGGGTGGTCGTTCATGGACTTACTTTACACCAGCCCAAATCCTCA GAAGAAATTTTACATTTATTGGATAATGGAAACAAAAACAGGACACAACATCCCACTGAT ATGAATGCCACATCTTCTCGTTCTCATGCTGTTTTCCAAATTTACTTGCGACAACAAGAC AAAACAGCAAGTATCAATCAAAATGTCCGTATTGCCAAGATGTCACTCATTGACCTGGCA GGATCTGAGCGAGCAAGTACTTCCGGTGCTAAGGGGACCCGATTTGTAGAAGGCACAAAT ATTAATAGATCACTTTTAGCTCTTGGGAATGTCATCAATGCCTTAGCAGATTCAAAGAGA AAGAATCAGCATATCCCTTACAGAAATAGTAAGCTTACTCGCTTGTTAAAGGATTCTCTT GGAGGAAACTGTCAAACTATAATGATAGCTGCTGTTAGTCCTTCCTCTGTATTCTACGAT GACACATATAACACTCTTAAGTATGCTAACCGGGCAAAGGACATTAAATCTTCTTTGAAG AGCAATGTTCTTAATGTCAATAATCATATAACTCAATATGTAAAGATCTGTAATGAGCAG AAGGCAGAGATTTTATTGTTAAAAGAAAAACTAAAAGCCTATGAAGAACAGAAAGCCTTC ACTAATGAAAATGACCAAGCAAAGTTAATGATTTCAAACCCTCAGGAAAAAGAAATCGAA AGGTTTCAAGAAATCCTGAACTGCTTGTTCCAGAATCGAGAAGAAATTAGACAAGAATAT CTGAAGTTGGAAATGTTACTTAAAGAAAATGAACTTAAATCATTCTACCAACAACAGTGC CATAAACAAATAGAAATGATGTGTTCTGAAGACAAAGTAGAAAAGGCCACTGGAAAACGA GATCATAGACTTGCAATGTTGAAAACTCGTCGCTCCTACCTGGAGAAAAGGAGGGAGGAG GAATTGAAGCAATTTGATGAGAATACTAATTGGCTCCATCGTGTCGAAAAAGAAATGGGA CTCTTAAGTCAAAACGGTCATATTCCAAAGGAACTCAAGAAAGATCTTCATTGTCACCAT TTGCACCTCCAGAACAAAGATTTGAAAGCACAAATTAGACATATGATGGATCTAGCTTGT CTTCAGGAACAGCAACACAGGCAGACTGAAGCAGTATTGAATGCTTTACTTCCAACCCTA AGAAAACAATATTGCACATTAAAAGAAGCCGGCCTGTCAAATGCTGCTTTTGAATCTGAC TTCAAAGAGATCGAACATTTGGTAGAGAGGAAAAAAGTGGTAGTTTGGGCTGACCAAACT GCCGAACAACCAAAGCAAAACGATCTACCAGGGATTTCTGTTCTTATGACCTTTCCACAA CTTGGACCAGTTCAGCCTATTCCTTGTTGCTCATCTTCAGGTGGAACTAATCTGGTTAAG ATTCCTACAGAAAAAAGAACTCGGAGAAAACTAATGCCATCTCCCTTGAAAGGACAGCAT ACTCTAAAGTCTCCACCATCTCAAAGTGTGCAGCTCAATGATTCTCTTAGCAAAGAACTT CAGCCTATTGTATATACACCAGAAGACTGTAGAAAAGCTTTTCAAAATCCGTCTACAGTA ACCTTAATGAAACCATCATCATTTACTACAAGTTTTCAGGCTATCAGCTCAAACATAAAC AGTGATAATTGTCTGAAAATGTTGTGTGAAGTAGCTATCCCTCATAATAGAAGAAAAGAA TGTGGACAGGAGGACTTGGACTCTACATTTACTATATGTGAAGACATCAAGAGCTCGAAG TGTAAATTACCCGAACAAGAATCACTACCAAATGATAACAAAGACATTTTACAACGGCTT GATCCTTCTTCATTCTCAACTAAGCATTCTATGCCTGTACCAAGCATGGTGCCATCCTAC ATGGCAATGACTACTGCTGCCAAAAGGAAACGGAAATTAACAAGTTCTACATCAAACAGT TCGTTAACTGCAGACGTAAATTCTGGATTTGCCAAACGTGTTCGACAAGATAATTCAAGT GAGAAGCACTTACAAGAAAACAAACCAACAATGGAACATAAAAGAAACATCTGTAAAATA AATCCAAGCATGGTTAGAAAATTTGGAAGAAATATTTCAAAAGGAAATCTAAGATAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:29441
Chromosome Location	11
Locus	Not Available
References	Luboshits G, Benayahu D: MS-KIF18A, new kinesin; structure and cellular expression. Gene. 2005 May 23;351:19-28. 15878648 Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. 11230166 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, Woehlke G, Mayer TU: The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol. 2007 Mar 20;17(6):488-98. Epub 2007 Mar 8. 17346968 Luboshits G, Benayahu D: MS-KIF18A, a kinesin, is associated with estrogen receptor. J Cell Biochem. 2007 Feb 15;100(3):693-702. 17006958 Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L: The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell. 2008 Feb;14(2):252-62. doi: 10.1016/j.devcel.2007.11.014. 18267093 Zusev M, Benayahu D: New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A. J Cell Physiol. 2008 Dec;217(3):618-25. doi: 10.1002/jcp.21525. 18680169 Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648 Gardner MK, Odde DJ, Bloom K: Kinesin-8 molecular motors: putting the brakes on chromosome oscillations. Trends Cell Biol. 2008 Jul;18(7):307-10. doi: 10.1016/j.tcb.2008.05.003. Epub 2008 May 29. 18513970 Huang Y, Yao Y, Xu HZ, Wang ZG, Lu L, Dai W: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. Cell Cycle. 2009 Aug 15;8(16):2643-9. Epub 2009 Aug 29. 19625775 Zusev M, Benayahu D: The regulation of MS-KIF18A expression and cross talk with estrogen receptor. PLoS One. 2009 Jul 28;4(7):e6407. doi: 10.1371/journal.pone.0006407. 19636373 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231