Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

NameKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms
  • 2-aminoadipate aminotransferase
  • 2-aminoadipate transaminase
  • AadAT
  • Alpha-aminoadipate aminotransferase
  • KAT/AadAT
  • KAT2
  • Kynurenine aminotransferase II
  • Kynurenine--oxoglutarate aminotransferase II
  • Kynurenine--oxoglutarate transaminase 2
  • Kynurenine--oxoglutarate transaminase II
Gene NameAADAT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001450|Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
Number of residues425
Molecular Weight47351.17
Theoretical pI6.96
GO Classification
Functions
  • kynurenine-oxoglutarate transaminase activity
  • 2-aminoadipate transaminase activity
  • pyridoxal phosphate binding
  • protein homodimerization activity
Processes
  • glutamate metabolic process
  • tryptophan catabolic process
  • tryptophan catabolic process to kynurenine
  • biosynthetic process
  • kynurenine metabolic process
  • L-kynurenine metabolic process
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • L-lysine catabolic process to acetyl-CoA via saccharopine
  • lysine catabolic process
  • 2-oxoglutarate metabolic process
Components
  • mitochondrial matrix
General FunctionPyridoxal phosphate binding
Specific FunctionTransaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID6165634
UniProtKB IDQ8N5Z0
UniProtKB Entry NameAADAT_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0016189|Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)
ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG
ACCATGAGTGAGAAACGGGCTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTG
GCTGGTGGCTTACCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAA
AATGGAAAGACCATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCG
AGTGCTGGAATTCCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAAT
CCTCCTACCATCCATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGC
AGCCAACAAGGTCTTTGTAAGGTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTC
CTAGATGAACCTGCTTATTCAGGAACTCTTCAAAGTCTGCACCCACTGGGCTGCAACATT
ATTAATGTTGCCAGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCC
AGATGGAAACCAGAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACT
GTTCCAAATGGCAACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATC
TATGAGCTTGCAAGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTC
CAGTTTAACAAGTTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATC
AGAGCTGACTCTTTTTCAAAAATCATTTCCTCTGGGTTGAGAATAGGATTTTTAACTGGT
CCAAAACCCTTAATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGC
ACTTTTAACCAGCTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATG
GCTCATGTAGACAGGGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCT
GCAGACAAGTGGTTAACTGGTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTA
TGGATTAAAGTTAAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAG
ATGGGGGTATTAATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCT
TACTTGAGAGCATCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTGGCCTTCCAGGTA
TTAGCACAACTTATAAAAGAATCTTTATGA
GenBank Gene IDAF097994
GeneCard IDNot Available
GenAtlas IDAADAT
HGNC IDHGNC:17929
Chromosome Location4
Locus4q33
References
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