5-hydroxytryptamine receptor 3D

Name5-hydroxytryptamine receptor 3D
Synonyms
  • 5-HT3-D
  • Serotonin receptor 3D
Gene NameHTR3D
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008662|5-hydroxytryptamine receptor 3D
MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPAAFQAVFDRKAIGPVTNYS
VATHVNISFTLSAIWNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLS
DVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMSRS
FQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPS
GILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALM
QTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCP
TAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVE
LWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
Number of residues454
Molecular Weight50190.625
Theoretical pINot Available
GO Classification
Functions
  • serotonin-activated cation-selective channel activity
  • serotonin receptor activity
Processes
  • neurological system process
  • transmembrane transport
  • ion transmembrane transport
  • serotonin receptor signaling pathway
  • regulation of membrane potential
  • cation transmembrane transport
Components
  • plasma membrane
  • integral component of membrane
  • synapse
  • neuron projection
General FunctionSerotonin-activated cation-selective channel activity
Specific FunctionThis is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Pfam Domain Function
Transmembrane Regions233-253 265-285 307-327 432-452
GenBank Protein IDNot Available
UniProtKB IDQ70Z44
UniProtKB Entry Name5HT3D_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013339|5-hydroxytryptamine receptor 3D (HTR3D)
ATGGAAAGAGGCTGGTTCCATGGGAAAGGATTCCTCCTTGGCTTCATCCTCCACCTGCTG
CTGCAAGATTCACACCTTCAACTGGTGACATCGTTCCTGTGGCTAAATATGTGGAACCCA
GATGAATGCGGAGGCATCAAGAAGTCCGGCATGGCAACTGAGAACCTATGGCTTTCAGAT
GTCTTCATCGAGGAGTCTGTGGATCAGACACCTGCAGGTCTCATGGCTAGTATGTCAATA
GTGAAGGCCACATCAAACACAATAAGCCAATGTGGGTGGTCAGCATCTGCAAACTGGACA
CCTTCTATTTCCCCTTCCATGGACAGAGGTGAACGCTCTCCTTCAGCCCTTTCACCTACA
CAGGTAACCCGGGCATGGAGAAGGATGTCCAGGAGCTTTCAAATACATCACAGAACCTCA
TTCAGAACAAGGAGGGAGTGGGTACTGCTGGGTATCCAAAAAAGAACAATAAAGGTGACC
GTGGCCACTAACCAGTATGAACAAGCCATCTTCCATGTGGCCATCAGGCGCAGGTGCAGG
CCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCC
CTCAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTG
CTGGGCTACAGCGTCTTCCTGCTCATGATGAATGACTTGCTCCCAGCCACTAGCACTTCA
TCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTC
GCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTG
CTGCACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTG
CACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCG
GGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATG
CCAGGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAA
CACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGAC
GCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGC
CTCTGGAACACCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:24004
Chromosome Location3
LocusNot Available
References
  1. Niesler B, Frank B, Kapeller J, Rappold GA: Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene. 2003 May 22;310:101-11. 12801637
  2. Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, Bonisch H, Gothert M, Rappold G, Bruss M: Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol. 2007 Jul;72(1):8-17. Epub 2007 Mar 28. 17392525
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