Keratin-associated protein 5-2

NameKeratin-associated protein 5-2
Synonyms
  • KAP5-8
  • KAP5.2
  • Keratin-associated protein 5-8
  • Keratin-associated protein 5.2
  • Keratin-associated protein 5.8
  • KRTAP5-8
  • KRTAP5.2
  • KRTAP5.8
  • Ultrahigh sulfur keratin-associated protein 5.2
Gene NameKRTAP5-2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013142|Keratin-associated protein 5-2
MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCK
PCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
Number of residues177
Molecular Weight16270.68
Theoretical pINot Available
GO Classification
Components
  • keratin filament
General FunctionNot Available
Specific FunctionIn the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ701N4
UniProtKB Entry NameKRA52_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013143|Keratin-associated protein 5-2 (KRTAP5-2)
ATGGGCTGCTGTGGCTGCTCCAGAGGCTGTGGCTCCGGCTGTGGGGGCTGTGGCTCCAGC
TGTGGGGGTTGTGGCTCTGGCTGTGGGGGCTGTGGCTCCGGCCGTGGGGGCTGTGGCTCT
GGCTGTGGGGGCTGCAGCTCCAGCTGTGGGGGATGTGGCTCCAGATGTTATGTGCCTGTC
TGCTGCTGCAAGCCCGTGTGCTCCTGGGTGCCAGCCTGTTCCTGCACCAGCTGTGGCTCC
TGTGGGGGCTCCAAGGGGGGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGGCTGTGGCTCC
TGTGGGGGTTCCAAGGGGGGCTGTGGTTCTTGTGGCTGCTCCCAGTCCAGCTGTTGTAAG
CCCTGTTGCTGCTCCTCAGGCTGTGGATCATCCTGCTGCCAGTCCAGCTGCTGCAAGCCC
TGCTGCTGCCAGTCCAGCTGCTGTGTCCCCGTGTGCTGCCAGTCCAGCTGCTGCAAGCCC
TGTTGCTGCCAGTCCAACTGTTGTGTCCCTGTGTGCTGCCAGTGTAAGATCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:23597
Chromosome Location11
LocusNot Available
References
  1. Yahagi S, Shibuya K, Obayashi I, Masaki H, Kurata Y, Kudoh J, Shimizu N: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Biochem Biophys Res Commun. 2004 Jun 4;318(3):655-64. 15144888
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334