Lengsin

NameLengsin
Synonyms
  • GLULD1
  • Glutamate-ammonia ligase domain-containing protein 1
  • Lens glutamine synthase-like
  • LGS
Gene NameLGSN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004462|Lengsin
MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDS
SQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMP
RGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPL
LTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFM
QELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIA
SFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMA
PSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVL
AATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETF
IRYFVAMKKYELENEEIAAERNKFLEYFI
Number of residues509
Molecular Weight57277.46
Theoretical pI6.3
GO Classification
Functions
  • glutamate-ammonia ligase activity
Processes
  • glutamine biosynthetic process
Components
  • plasma membrane
General FunctionGlutamate-ammonia ligase activity
Specific FunctionMay act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID7341339
UniProtKB IDQ5TDP6
UniProtKB Entry NameLGSN_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016738|Lengsin (LGSN)
ATGAATAATGAAGAGGACCTTCTGCAGGAGGACTCAACAAGAGATGAAGGCAATGAGACT
GAAGCCAACAGCATGAACACATTAAGAAGGACAAGGAAGAAAGTCACTAAACCATATGTT
TGTTCAACTGAAGTGGGAGAAACGGATATGTCCAATTCAAATGATTGCATGAGGGACAGC
AGTCAAATTTTGACCCCACCTCAACTCTCTTCTAGAATGAAACACATTAGACAAGCCATG
GCCAAAAATCGCCTCCAGTTTGTACGATTTGAAGCAACAGACCTCCACGGCGTGTCCAGG
TCTAAGACTATCCCTGCACACTTTTTTCAAGAGAAAGTGAGCCATGGTGTTTGCATGCCC
CGAGGTTATCTTGAAGTGATACCAAATCCAAAGGACAATGAAATGAATAACATAAGAGCC
ACATGTTTTAATAGCGACATAGTCCTAATGCCAGAGTTATCAACCTTTAGAGTTTTGCCA
TGGGCTGACAGAACTGCAAGAGTGATATGTGATACCTTCACTGTGACTGTCTCTGGGATG
TCGATAGGAAGAAAAACATGTTCTGCAGCACTTCTGGAACTGAGCAGCTCACGATCACTG
GGAAAAAATGGTTGGCAGGACTCTTGA
GenBank Gene IDAF242388
GeneCard IDNot Available
GenAtlas IDGLULD1
HGNC IDHGNC:21016
Chromosome Location6
Locus6pter-q22.33
References
  1. Grassi F, Moretto N, Rivetti C, Cellai S, Betti M, Marquez AJ, Maraini G, Ottonello S: Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens. Biochem Biophys Res Commun. 2006 Nov 17;350(2):424-9. Epub 2006 Sep 25. 17010935
  2. Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K: Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Mol Vis. 2002 Jun 15;8:171-84. 12107413
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