T3DB: Tyrosine-protein phosphatase non-receptor type 21

Name	Tyrosine-protein phosphatase non-receptor type 21
Synonyms	3.1.3.48 Protein-tyrosine phosphatase D1 PTPD1
Gene Name	PTPN21
Organism	Human
Amino acid sequence	>lcl\|BSEQ0013566\|Tyrosine-protein phosphatase non-receptor type 21 MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELRE VTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQY YLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEG IFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVAR HKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQD NLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS YAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVP ELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVH HSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSAS AAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFE EESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTT AEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEY ERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSV SGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNT VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY LEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVL DMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI
Number of residues	1174
Molecular Weight	133279.965
Theoretical pI	Not Available
GO Classification	Functions protein tyrosine phosphatase activity Processes protein dephosphorylation peptidyl-tyrosine dephosphorylation Components cytoplasm cytoskeleton
General Function	Protein tyrosine phosphatase activity
Specific Function	Not Available
Pfam Domain Function	Y_phosphatase (PF00102 ) FERM_M (PF00373 ) FERM_C (PF09380 ) FERM_N (PF09379 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q16825
UniProtKB Entry Name	PTN21_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013567\|Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAG AGTTGCCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCC GTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTG GAAAAACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGA GTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCA ATTCAGCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCC CAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCT CCTGATGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAG AGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCC AACATGTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATT CAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA CACAAGTTTTACAGACTAAACCAGTGTAACCTGCAAACTCAGACTGTCACAGTGAACCCA ATCAGGAGGAGGTCTTCTTCAAGGATGTCTCTGCCTAAACCCCAGCCCTACGTGATGCCT CCCCCACCGCAGTTGCACTATAATGGACATTATACAGAACCATATGCTTCTTCCCAAGAT AACCTCTTTGTGCCCAACCAGAACGGATACTACTGTCACTCTCAGACAAGCTTGGATAGA GCCCAGATTGACCTCAACGGTCGGATCCGTAATGGCAGTGTCTACAGTGCACACAGCACC AACTCCTTAAATAATCCTCAGCCCTACTTGCAGCCCTCGCCGATGTCGTCCAACCCTAGC ATCACCGGGAGTGACGTCATGAGGCCTGACTACCTCCCGTCCCATCGGCACAGCGCCGTG ATACCCCCGTCCTACCGCCCCACCCCAGACTATGAGACTGTGATGAAGCAGCTCAACAGG GGCCTGGTGCATGCGGAACGGCAGAGCCACTCGCTGCGAAACCTCAACATCGGCAGCTCG TACGCCTACAGCAGGCCCGCGGCGCTGGTCTACAGCCAGCCCGAGATCCGCGAGCACGCA CAGCTCCCCTCGCCAGCGGCCGCACACTGCCCGTTCAGCCTGAGCTACAGCTTCCACAGC CCGTCTCCCTACCCCTACCCTGCCGAGCGGCGGCCCGTGGTGGGCGCGGTCAGCGTGCCG GAGCTGACCAATGCGCAGCTGCAGGCGCAGGACTACCCGTCTCCCAACATCATGCGGACG CAGGTGTACCGGCCACCCCCACCCTACCCGCCCCCCAGGCCCGCCAACAGCACGCCAGAC CTGTCCCGCCACCTTTACATCAGCAGCAGCAACCCCGACCTCATCACGCGGCGCGTGCAC CACTCGGTGCAAACGTTCCAGGAGGACAGCCTGCCCGTGGCGCACTCGCTGCAGGAGGTC AGCGAGCCCCTCACCGCCGCGCGCCACGCGCAGCTGCACAAACGGAACAGCATCGAGGTG GCCGGGCTCAGCCACGGCCTGGAGGGCCTGCGGCTCAAGGAGCGCACCCTATCCGCGTCG GCGGCAGAGGTGGCGCCGCGAGCCGTCTCGGTGGGCTCCCAGCCCAGCGTTTTCACCGAG AGGACACAGCGAGAAGGGCCGGAGGAGGCGGAGGGCTTGAGGTACGGCCATAAGAAGTCC CTGTCGGACGCCACCATGCTAATCCACAGCAGCGAGGAGGAGGAGGACGAGGACTTCGAG GAGGAGAGCGGGGCCCGGGCGCCTCCTGCACGTGCGCGCGAGCCTCGGCCCGGCCTGGCC CAGGACCCACCTGGCTGCCCTCGCGTCCTGCTCGCCGGGCCCCTGCACATCCTGGAGCCC AAGGCCCACGTCCCAGACGCGGAGAAGAGGATGATGGACAGCAGCCCCGTCCGCACGACC GCAGAGGCCCAGCGGCCCTGGAGAGACGGGCTGCTGATGCCCTCCATGTCGGAGTCCGAC CTCACCACGTCAGGCCGCTACCGAGCCCGGAGGGACTCTCTGAAGAAAAGGCCGGTGTCG GACCTTCTCTCTGGGAAGAAGAACATCGTGGAAGGGCTCCCGCCTCTAGGGGGAATGAAA AAGACTCGAGTAGATGCAAAAAAAATTGGTCCTCTTAAACTGGCTGCCCTAAATGGACTC TCCCTATCTCGAGTGCCTCTGCCTGATGAAGGAAAGGAAGTGGCTACCAGAGCAACGAAT GATGAAAGGTGTAAAATTCTGGAACAACGATTAGAACAAGGAATGGTATTCACAGAATAT GAAAGAATTCTTAAGAAACGGCTAGTTGATGGGGAGTGCTCAACAGCACGACTCCCTGAA AATGCAGAAAGAAATCGATTCCAAGATGTTCTTCCTTATGATGATGTGAGAGTGGAGTTG GTCCCAACTAAAGAAAACAACACTGGTTACATCAACGCATCACATATTAAGGTCTCTGTC AGTGGAATCGAATGGGATTATATTGCCACACAGGGACCATTACAGAATACCTGTCAAGAT TTTTGGCAGATGGTATGGGAACAGGGAATTGCAATTATAGCAATGGTGACAGCAGAAGAG GAGGGTGGAAGGGAGAAGAGCTTTAGGTACTGGCCACGACTTGGTTCCAGGCACAACACT GTCACCTATGGAAGGTTTAAGATCACGACCCGGTTCCGCACAGACTCTGGCTGCTATGCC ACCACAGGCCTGAAGATGAAGCACCTCCTTACTGGGCAAGAGAGGACCGTCTGGCACCTC CAATACACAGACTGGCCTGAACATGGCTGTCCAGAAGACCTCAAGGGATTTTTATCATAT CTTGAAGAGATCCAGTCTGTTCGACGCCATACAAATAGCACAAGTGATCCCCAAAGCCCC AACCCTCCGTTGTTGGTCCACTGCAGTGCTGGGGTAGGAAGGACTGGCGTGGTGATTTTG TCGGAGATCATGATCGCCTGCCTGGAACACAATGAGGTGCTGGACATCCCGAGAGTGCTG GACATGCTGAGGCAACAGAGAATGATGCTGGTGCAGACTCTCTGCCAGTACACATTTGTG TACAGAGTCCTCATCCAGTTCCTGAAAAGCTCCAGGCTCATCTAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:9651
Chromosome Location	14
Locus	Not Available
References	Moller NP, Moller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A: Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7477-81. 7519780 Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. 12508121 Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. 21406692 Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569