T3DB: Cyclic nucleotide-gated olfactory channel

Name	Cyclic nucleotide-gated olfactory channel
Synonyms	CNCA CNCA1 CNCG2 CNG channel alpha-2 CNG-2 CNG2 Cyclic nucleotide-gated cation channel 2 Cyclic nucleotide-gated channel alpha-2
Gene Name	CNGA2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0017677\|Cyclic nucleotide-gated olfactory channel MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA ADEP
Number of residues	664
Molecular Weight	76047.505
Theoretical pI	Not Available
GO Classification	Functions cGMP binding cAMP binding intracellular cGMP activated cation channel activity voltage-gated potassium channel activity Processes phototransduction, visible light potassium ion transmembrane transport organelle organization regulation of membrane potential sensory perception of smell Components Golgi membrane ciliary membrane Golgi-associated vesicle membrane integral component of plasma membrane
General Function	Voltage-gated potassium channel activity
Specific Function	Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Pfam Domain Function	Ion_trans (PF00520 ) cNMP_binding (PF00027 ) CLZ (PF16526 )
Transmembrane Regions	139-159 172-192 225-245 275-295 351-371 454-474
GenBank Protein ID	Not Available
UniProtKB ID	Q16280
UniProtKB Entry Name	CNGA2_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0017678\|Cyclic nucleotide-gated olfactory channel (CNGA2) ATGACCGAAAAAACCAATGGTGTGAAGAGCTCCCCAGCCAATAATCACAACCATCATGCA CCTCCTGCCATCAAGGCCAATGGCAAAGATGACCACAGGACAAGCAGCAGGCCACACTCT GCAGCTGACGATGACACCTCCTCAGAACTGCAGAGGCTGGCAGACGTGGATGCCCCACAG CAGGGAAGGAGTGGCTTCCGCAGGATAGTTCGCCTGGTGGGGATCATCAGAGAATGGGCC AACAAGAATTTCCGAGAGGAGGAACCTAGGCCTGACTCATTCCTCGAGCGTTTTCGTGGG CCTGAACTCCAGACTGTGACCACACAGGAGGGGGATGGCAAAGGCGACAAGGATGGCGAG GACAAAGGCACCAAGAAGAAATTTGAACTATTTGTCTTGGACCCAGCTGGGGATTGGTAC TACTGCTGGCTATTTGTCATTGCCATGCCCGTCCTTTACAACTGGTGCCTGCTGGTGGCC AGAGCCTGCTTCAGTGACCTACAGAAAGGCTACTACCTGGTGTGGCTGGTGCTGGATTAT GTCTCAGATGTGGTCTACATTGCGGACCTCTTCATCCGATTGCGCACAGGTTTCCTGGAG CAGGGGCTGCTGGTCAAAGATACCAAGAAACTGCGAGACAACTACATCCACACCCTGCAG TTCAAGCTGGATGTGGCTTCCATCATCCCCACTGACCTGATCTATTTTGCTGTGGACATC CACAGCCCTGAGGTGCGCTTCAACCGCCTGCTGCACTTTGCCCGCATGTTTGAGTTCTTT GACCGGACAGAGACACGCACCAACTACCCTAACATCTTCCGCATCAGCAACCTTGTCCTC TACATCTTGGTCATCATCCACTGGAATGCCTGCATCTATTATGCCATCTCCAAATCCATA GGCTTTGGGGTCGACACCTGGGTTTACCCAAACATCACTGACCCTGAGTATGGCTACCTG GCTAGGGAATACATCTATTGCCTTTACTGGTCCACACTGACTCTCACTACCATTGGGGAG ACACCACCCCCTGTAAAGGATGAGGAGTACCTATTTGTCATCTTTGACTTCCTGATTGGC GTCCTCATCTTTGCCACCATCGTGGGAAATGTGGGCTCCATGATCTCCAACATGAATGCC ACCCGGGCAGAGTTCCAGGCTAAGATCGATGCCGTGAAACACTACATGCAGTTCCGAAAG GTCAGCAAGGGGATGGAAGCCAAGGTCATTAGGTGGTTTGACTACTTGTGGACCAATAAG AAGACAGTGGATGAGCGAGAAATTCTCAAGAATCTGCCAGCCAAGCTCAGGGCTGAGATA GCCATCAATGTCCACTTGTCCACACTCAAGAAAGTGCGCATCTTCCATGATTGTGAGGCT GGCCTGCTGGTAGAGCTGGTACTGAAACTCCGTCCTCAGGTCTTCAGTCCTGGGGATTAC ATTTGCCGCAAAGGGGACATCGGCAAGGAGATGTACATCATTAAGGAGGGCAAACTGGCA GTGGTGGCTGATGATGGTGTGACTCAGTATGCTCTGCTGTCGGCTGGAAGCTGCTTTGGC GAGATCAGTATCCTTAACATTAAGGGCAGTAAAATGGGCAATCGACGCACAGCTAATATC CGCAGCCTGGGCTACTCAGATCTCTTCTGCTTGTCCAAGGATGATCTTATGGAAGCTGTG ACTGAGTACCCTGATGCCAAGAAAGTCCTAGAAGAGAGGGGTCGGGAGATCCTCATGAAG GAGGGACTGCTGGATGAGAACGAAGTGGCAACCAGCATGGAGGTCGACGTGCAGGAGAAG CTAGGGCAGCTGGAGACCAACATGGAAACCTTGTACACTCGCTTTGGCCGCCTGCTGGCT GAGTACACGGGGGCCCAGCAGAAGCTCAAGCAGCGCATCACAGTTCTGGAAACCAAGATG AAACAGAACAATGAAGATGACTACCTGTCTGATGGGATGAACAGCCCTGAGCTGGCTGCT GCTGACGAGCCATAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:2149
Chromosome Location	X
Locus	Not Available
References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Distler M, Biel M, Flockerzi V, Hofmann F: Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. Neuropharmacology. 1994 Nov;33(11):1275-82. 7532814 Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. 16959974