T3DB: Metabotropic glutamate receptor 2

Name	Metabotropic glutamate receptor 2
Synonyms	GPRC1B MGLUR2
Gene Name	GRM2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0010682\|Metabotropic glutamate receptor 2 MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Number of residues	872
Molecular Weight	95566.715
Theoretical pI	8.16
GO Classification	Functions G-protein coupled receptor activity glutamate receptor activity calcium channel regulator activity group II metabotropic glutamate receptor activity Processes synaptic transmission glutamate secretion negative regulation of adenylate cyclase activity regulation of synaptic transmission, glutamatergic G-protein coupled glutamate receptor signaling pathway Components intracellular plasma membrane cell junction integral component of plasma membrane dendrite presynaptic membrane axon
General Function	Group ii metabotropic glutamate receptor activity
Specific Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Pfam Domain Function	7tm_3 (PF00003 ) ANF_receptor (PF01094 ) NCD3G (PF07562 )
Transmembrane Regions	568-590 605-625 637-655 680-700 726-747 761-783 794-819
GenBank Protein ID	999416
UniProtKB ID	Q14416
UniProtKB Entry Name	GRM2_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0010683\|Metabotropic glutamate receptor 2 (GRM2) ATGGGATCGCTGCTTGCGCTCCTGGCACTGCTGCTGCTGTGGGGTGCTGTGGCTGAGGGC CCAGCCAAGAAGGTGCTGACCCTGGAGGGAGACTTGGTGCTGGGTGGGCTGTTCCCAGTG CACCAGAAGGGCGGCCCAGCAGAGGACTGTGGTCCTGTCAATGAGCACCGTGGCATCCAG CGCCTGGAGGCCATGCTTTTTGCACTGGACCGCATCAACCGTGACCCGCACCTGCTGCCT GGCGTGCGCCTGGGTGCACACATCCTCGACAGTTGCTCCAAGGACACACATGCGCTGGAG CAGGCACTGGACTTTGTGCGTGCCTCACTCAGCCGTGGTGCTGATGGCTCACGCCACATC TGCCCCGACGGCTCTTATGCGACCCATGGTGATGCTCCCACTGCCATCACTGGTGTTATT GGCGGTTCCTACAGTGATGTCTCCATCCAGGTGGCCAACCTCTTGAGGCTATTTCAGATC CCACAGATTAGCTACGCCTCTACCAGTGCCAAGCTGAGTGACAAGTCCCGCTATGACTAC TTTGCCCGCACAGTGCCTCCTGACTTCTTCCAAGCCAAGGCCATGGCTGAGATTCTCCGC TTCTTCAACTGGACCTATGTGTCCACTGTGGCGTCTGAGGGCGACTATGGCGAGACAGGC ATTGAGGCCTTTGAGCTAGAGGCTCGTGCCCGCAACATCTGTGTGGCCACCTCGGAGAAA GTGGGCCGTGCCATGAGCCGCGCGGCCTTTGAGGGTGTGGTGCGAGCCCTGCTGCAGAAG CCCAGTGCCCGCGTGGCTGTCCTGTTCACCCGTTCTGAGGATGCCCGGGAGCTGCTTGCT GCCAGCCAGCGCCTCAATGCCAGCTTCACCTGGGTGGCCAGTGATGGTTGGGGGGCCCTG GAGAGTGTGGTGGCAGGCAGTGAGGGGGCTGCTGAGGGTGCTATCACCATCGAGCTGGCC TCCTACCCCATCAGTGACTTTGCCTCCTACTTCCAGAGCCTGGACCCTTGGAACAACAGC CGGAACCCCTGGTTCCGTGAATTCTGGGAGCAGAGGTTCCGCTGCAGCTTCCGGCAGCGA GACTGCGCAGCCCACTCTCTCCGGGCTGTGCCCTTTGAGCAGGAGTCCAAGATCATGTTT GTGGTCAATGCAGTGTACGCCATGGCCCATGCGCTCCACAACATGCACCGTGCCCTCTGC CCCAACACCACCCGGCTCTGTGACGCGATGCGGCCAGTTAACGGGCGCCGCCTCTACAAG GACTTTGTGCTCAACGTCAAGTTTGATGCCCCCTTTCGCCCAGCTGACACCCACAATGAG GTCCGCTTTGACCGCTTTGGTGATGGTATTGGCCGCTACAACATCTTCACCTATCTGCGT GCAGGCAGTGGGCGCTATCGCTACCAGAAGGTGGGCTACTGGGCAGAAGGCTTGACTCTG GACACCAGCCTCATCCCATGGGCCTCACCCTCAGCCGGCCCCCTGCCCGCCTCTCGCTGC AGTGAGCCCTGCCTCCAGAATGAGGTGAAGAGTGTGCAGCCGGGCGAAGTCTGCTGCTGG CTCTGCATTCCGTGCCAGCCCTATGAGTACCGATTGGACGAATTCACTTGCGCTGATTGT GGCCTGGGCTACTGGCCCAATGCCAGCCTGACTGGCTGCTTCGAACTGCCCCAGGAGTAC ATCCGCTGGGGCGATGCCTGGGCTGTGGGACCTGTCACCATCGCCTGCCTCGGTGCCCTG GCCACCCTCTTTGTGCTGGGTGTCTTTGTGCGGCACAATGCCACACCAGTGGTCAAGGCC TCAGGTCGGGAGCTCTGCTACATCCTGCTGGGTGGTGTCTTCCTCTGCTACTGCATGACC TTCATCTTCATTGCCAAGCCATCCACGGCAGTGTGTACCTTACGGCGTCTTGGTTTGGGC ACTGCCTTCTCTGTCTGCTACTCAGCCCTGCTCACCAAGACCAACCGCATTGCACGCATC TTCGGTGGGGCCCGGGAGGGTGCCCAGCGGCCACGCTTCATCAGTCCTGCCTCACAGGTG GCCATCTGCCTGGCACTTATCTCGGGCCAGCTGCTCATCGTGGTCGCCTGGCTGGTGGTG GAGGCACCGGGCACAGGCAAGGAGACAGCCCCCGAACGGCGGGAGGTGGTGACACTGCGC TGCAACCACCGCGATGCAAGTATGTTGGGCTCGCTGGCCTACAATGTGCTCCTCATCGCG CTCTGCACGCTTTATGCCTTCAAGACTCGCAAGTGCCCCGAAAACTTCAACGAGGCCAAG TTCATTGGCTTCACCATGTACACCACCTGCATCATCTGGCTGGCATTCCTGCCCATCTTC TATGTCACCTCCAGTGACTACCGGGTACAGACCACCACCATGTGCGTGTCAGTCAGCCTC AGCGGCTCCGTGGTGCTTGGCTGCCTCTTTGCGCCCAAGCTGCACATCATCCTCTTCCAG CCGCAGAAGAACGTGGTTAGCCACCGGGCACCCACCAGCCGCTTTGGCAGTGCTGCTGCC AGGGCCAGCTCCAGCCTTGGCCAAGGGTCTGGCTCCCAGTTTGTCCCCACTGTTTGCAAT GGCCGTGAGGTGGTGGACTCGACAACGTCATCGCTTTGA
GenBank Gene ID	L35318
GeneCard ID	Not Available
GenAtlas ID	GRM2
HGNC ID	HGNC:4594
Chromosome Location	3
Locus	3p21.1
References	Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R: Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur J Neurosci. 1995 Apr 1;7(4):622-9. 7620613 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC: Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24. 18297054 Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, Gonzalez-Maeso J: Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012 Dec 28;287(53):44301-19. doi: 10.1074/jbc.M112.413161. Epub 2012 Nov 5. 23129762 Delille HK, Becker JM, Burkhardt S, Bleher B, Terstappen GC, Schmidt M, Meyer AH, Unger L, Marek GJ, Mezler M: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades. Neuropharmacology. 2012 Jun;62(7):2184-91. doi: 10.1016/j.neuropharm.2012.01.010. Epub 2012 Jan 25. 22300836