Glutamate receptor ionotropic, kainate 3

NameGlutamate receptor ionotropic, kainate 3
Synonyms
  • EAA5
  • Excitatory amino acid receptor 5
  • GluK3
  • GluR-7
  • GLUR7
  • Glutamate receptor 7
Gene NameGRIK3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037089|Glutamate receptor ionotropic, kainate 3
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
Number of residues919
Molecular Weight104036.06
Theoretical pI7.69
GO Classification
Functions
  • extracellular-glutamate-gated ion channel activity
  • glutamate receptor activity
  • kainate selective glutamate receptor activity
  • ionotropic glutamate receptor activity
  • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
Processes
  • regulation of membrane potential
  • negative regulation of synaptic transmission, glutamatergic
  • glutamate receptor signaling pathway
  • synaptic transmission, glutamatergic
  • synaptic transmission
  • ionotropic glutamate receptor signaling pathway
  • G-protein coupled glutamate receptor signaling pathway
  • ion transmembrane transport
  • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
Components
  • perikaryon
  • presynaptic membrane
  • terminal bouton
  • axon
  • kainate selective glutamate receptor complex
  • postsynaptic membrane
  • plasma membrane
  • cell junction
  • dendrite cytoplasm
  • integral component of plasma membrane
  • dendrite
General FunctionKainate selective glutamate receptor activity
Specific FunctionReceptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
Pfam Domain Function
Transmembrane Regions564-584 637-657 821-841
GenBank Protein ID790534
UniProtKB IDQ13003
UniProtKB Entry NameGRIK3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010587|Glutamate receptor ionotropic, kainate 3 (GRIK3)
ATGACCGCTCCCTGGCGGCGCCTCCGGAGTCTGGTTTGGGAATACTGGGCCGGGCTCCTC
GTGTGCGCCTTCTGGATCCCGGACTCGCGCGGGATGCCCCACGTCATCCGGATCGGAGGA
ATCTTCGAGTATGCGGACGGCCCCAACGCCCAGGTCATGAATGCCGAGGAGCATGCCTTT
CGATTTTCTGCCAACATCATCAACAGGAACAGGACTCTGCTGCCCAACACAACCTTGACC
TATGACATACAGAGGATTCACTTCCATGACAGCTTCGAGGCGACCAAAAAGGCCTGTGAC
CAGCTGGCACTGGGCGTGGTGGCGATCTTCGGCCCATCACAGGGCTCCTGCACCAATGCC
GTCCAGTCCATCTGCAATGCCCTGGAGGTGCCCCACATCCAGCTGCGTTGGAAGCACCAC
CCGCTGGACAACAAGGACACCTTCTACGTGAACCTCTACCCCGACTACGCCTCGCTCAGC
CATGCCATCCTCGACCTGGTCCAGTACCTCAAGTGGCGGTCAGCCACCGTGGTCTATGAC
GACAGTACAGGGCTCATCCGACTGCAGGAGCTCATCATGGCCCCATCAAGATACAACATC
CGCCTGAAGATCCGTCAGCTCCCCATCGACTCTGACGACTCGCGCCCCTTGCTCAAGGAG
ATGAAGCGAGGCCGGGAATTCCGCATTATCTTCGACTGCAGCCACACTATGGCGGCCCAG
ATCCTCAAGCAGGCCATGGCCATGGGCATGATGACTGAGTACTACCACTTCATCTTCACC
ACTCTGGATCTCTACGCTTTAGACCTGGAGCCCTACCGCTACTCAGGCGTGAACCTGACA
GGATTCCGGATTCTCAATGTGGACAACCCACACGTCTCGGCCATTGTGGAGAAGTGGTCC
ATGGAGCGGCTGCAGGCAGCTCCCCGGTCCGAGTCTGGCCTGCTGGATGGAGTGATGATG
ACTGATGCAGCCTTACTGTACGACGCCGTCCATATCGTGTCCGTGTGCTACCAGCGGGCA
CCACAGATGACCGTGAACTCCCTGCAGTGCCATCGGCACAAGGCCTGGCGCTTTGGCGGC
CGCTTCATGAACTTCATCAAGGAGGCTCAATGGGAAGGATTAACTGGACGAATTGTTTTC
AACAAAACTAGTGGCTTGCGGACGGATTTTGATCTGGACATCATCAGCCTGAAAGAGGAT
GGCCTGGAGAAGGTTGGGGTGTGGAGTCCTGCCGACGGGCTCAACATCACTGAGGTTGCC
AAAGGCCGAGGCCCTAATGTCACCGACTCTCTGACAAACAGATCACTCATTGTCACCACA
GTGCTGGAGGAGCCCTTCGTCATGTTTCGGAAATCAGACAGGACGCTATACGGGAATGAC
CGGTTCGAGGGCTACTGCATCGACCTGCTAAAGGAGCTGGCCCACATCCTTGGTTTCTCC
TATGAGATCCGGCTGGTGGAGGACGGCAAGTACGGGGCACAGGATGACAAGGGCCAGTGG
AACGGCATGGTCAAGGAGCTCATCGACCACAAGGCAGATCTGGCCGTGGCCCCCCTGACC
ATCACCCATGTTCGAGAGAAGGCCATCGACTTCTCCAAGCCCTTCATGACACTTGGTGTG
AGCATCCTGTATCGAAAGCCCAATGGCACCAACCCCAGCGTCTTCTCCTTCCTCAATCCC
CTGTCCCCAGACATCTGGATGTATGTTCTCCTCGCCTACCTGGGGGTCAGCTGTGTCCTC
TTCGTCATCGCCAGGTTCAGCCCTTATGAGTGGTACGATGCTCACCCCTGCAACCCTGGC
TCCGAGGTGGTGGAAAATAACTTCACTCTGCTTAACAGCTTCTGGTTTGGAATGGGATCC
CTGATGCAGCAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGC
ATCTGGTGGTTCTTCACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTT
CTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGACCTGGCCAAGCAAACC
AAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAG
ATCTCCACCTTCGAGAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAG
AACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGCGCTGCTCATGGAGTCC
ACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATT
GACTCCAAGGGCTACGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACC
ATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCATGAAGGAGAAGTGGTGG
CGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAG
ATCGGGGGCATCTTCATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTG
GGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCAGCGTTCCTTCTGCAGC
ACCGTGGCCGATGAGATCCGTTTCTCCCTTACCTGCCAGCGTCGAGTCAAGCACAAGCCT
CAGCCTCCCATGATGGTCAAGACTGACGCCGTCATCAACATGCACACATTCAATGACCGC
CGGCTTCCCGGCAAGGACAGCATGGCCTGCAGCACATCCTTAGCCCCTGTGTTCCCCTAG
GenBank Gene IDU16127
GeneCard IDNot Available
GenAtlas IDGRIK3
HGNC IDHGNC:4581
Chromosome Location1
Locus1p34-p33
References
  1. Nutt SL, Hoo KH, Rampersad V, Deverill RM, Elliott CE, Fletcher EJ, Adams SL, Korczak B, Foldes RL, Kamboj RK: Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Receptors Channels. 1994;2(4):315-26. 7719709
  2. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. 16710414
  3. Puranam RS, Eubanks JH, Heinemann SF, McNamara JO: Chromosomal localization of gene for human glutamate receptor subunit-7. Somat Cell Mol Genet. 1993 Nov;19(6):581-8. 8128318
  4. Schiffer HH, Swanson GT, Masliah E, Heinemann SF: Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. J Neurosci. 2000 Dec 15;20(24):9025-33. 11124978
  5. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. 16959974