Kinesin heavy chain isoform 5A

NameKinesin heavy chain isoform 5A
Synonyms
  • Kinesin heavy chain neuron-specific 1
  • Neuronal kinesin heavy chain
  • NKHC
  • NKHC1
Gene NameKIF5A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009164|Kinesin heavy chain isoform 5A
MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQE
QVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEI
LDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTM
FICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETI
AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE
IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVS
GHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKS
VVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEES
YDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDE
INEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL
KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQL
TKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRI
KEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQ
ATPSSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQA
KLFPLHQETAAS
Number of residues1032
Molecular Weight117377.305
Theoretical pINot Available
GO Classification
Functions
  • motor activity
  • ATP-dependent microtubule motor activity, plus-end-directed
  • ATP binding
Processes
  • synaptic transmission
  • axon guidance
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • cytoskeleton-dependent intracellular transport
  • protein localization
  • microtubule-based movement
  • blood coagulation
  • small GTPase mediated signal transduction
Components
  • cytosol
  • perinuclear region of cytoplasm
  • kinesin complex
  • membrane
  • microtubule
General FunctionMotor activity
Specific FunctionMicrotubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ12840
UniProtKB Entry NameKIF5A_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019729|Kinesin heavy chain isoform 5A (KIF5A)
ATGGCGGAGACCAACAACGAATGTAGCATCAAGGTGCTCTGCCGATTCCGGCCCCTGAAC
CAGGCTGAGATTCTGCGGGGAGACAAGTTCATCCCCATTTTCCAAGGGGACGACAGCGTC
GTTATTGGGGGGAAGCCATATGTTTTTGACCGTGTATTCCCCCCAAACACGACTCAAGAG
CAAGTTTATCATGCATGTGCCATGCAGATTGTCAAAGATGTCCTTGCTGGCTACAATGGC
ACCATTTTTGCTTATGGACAGACATCCTCAGGGAAAACACATACCATGGAGGGAAAGCTG
CACGACCCTCAGCTGATGGGAATCATTCCTCGAATTGCCCGAGACATCTTCAACCACATC
TACTCCATGGATGAGAACCTTGAGTTCCACATCAAGGTTTCTTACTTTGAAATTTACCTG
GACAAAATTCGTGACCTTCTGGATGTGACCAAGACAAATCTGTCCGTGCACGAGGACAAG
AACCGGGTGCCATTTGTCAAGGGTTGTACTGAACGCTTTGTGTCCAGCCCGGAGGAGATT
CTGGATGTGATTGATGAAGGGAAATCAAATCGTCATGTGGCTGTCACCAACATGAATGAA
CACAGCTCTCGGAGCCACAGCATCTTCCTCATCAACATCAAGCAGGAGAACATGGAAACG
GAGCAGAAGCTCAGTGGGAAGCTGTATCTGGTGGACCTGGCAGGGAGTGAGAAGGTCAGC
AAGACTGGAGCAGAGGGAGCCGTGCTGGACGAGGCAAAGAATATCAACAAGTCACTGTCA
GCTCTGGGCAATGTGATCTCCGCACTGGCTGAGGGCACTAAAAGCTATGTTCCATATCGT
GACAGCAAAATGACAAGGATTCTCCAGGACTCTCTCGGGGGAAACTGCCGGACGACTATG
TTCATCTGTTGCTCACCATCCAGTTATAATGATGCAGAGACCAAGTCCACCCTGATGTTT
GGGCAGCGGGCAAAGACCATTAAGAACACTGCCTCAGTAAATTTGGAGTTGACTGCTGAG
CAGTGGAAGAAGAAATATGAGAAGGAGAAGGAGAAGACAAAGGCCCAGAAGGAGACGATT
GCGAAGCTGGAGGCTGAGCTGAGCCGGTGGCGCAATGGAGAGAATGTGCCTGAGACAGAG
CGCCTGGCTGGGGAGGAGGCAGCCCTGGGAGCCGAGCTCTGTGAGGAGACCCCTGTGAAT
GACAACTCATCCATCGTGGTGCGCATCGCGCCCGAGGAGCGGCAGAAATACGAGGAGGAG
ATCCGCCGTCTCTATAAGCAGCTTGACGACAAGGATGATGAAATCAACCAACAAAGCCAA
CTCATAGAGAAGCTCAAGCAGCAAATGCTGGACCAGGAAGAGCTGCTGGTGTCCACCCGA
GGAGACAACGAGAAGGTCCAGCGGGAGCTGAGCCACCTGCAATCAGAGAACGATGCCGCT
AAGGATGAGGTGAAGGAAGTGCTGCAGGCCCTGGAGGAGCTGGCTGTGAACTATGACCAG
AAGTCCCAGGAGGTGGAGGAGAAGAGCCAGCAGAACCAGCTTCTGGTGGATGAGCTGTCT
CAGAAGGTGGCCACCATGCTGTCCCTGGAGTCTGAGTTGCAGCGGCTACAGGAGGTCAGT
GGACACCAGCGAAAACGAATTGCTGAGGTGCTGAACGGGCTGATGAAGGATCTGAGCGAG
TTCAGTGTCATTGTGGGCAACGGGGAGATTAAGCTGCCAGTGGAGATCAGTGGGGCCATC
GAGGAGGAGTTCACTGTGGCCCGACTCTACATCAGCAAAATCAAATCAGAAGTCAAGTCT
GTGGTCAAGCGGTGCCGGCAGCTGGAGAACCTCCAGGTGGAGTGTCACCGCAAGATGGAA
GTGACCGGGCGGGAGCTCTCATCCTGCCAGCTCCTCATCTCTCAGCATGAGGCCAAGATC
CGCTCGCTTACGGAATACATGCAGAGCGTGGAGCTAAAGAAGCGGCACCTGGAAGAGTCC
TATGACTCCTTGAGCGATGAGCTGGCCAAGCTCCAGGCCCAGGAAACTGTGCATGAAGTG
GCCCTGAAGGACAAGGAGCCTGACACTCAGGATGCAGATGAAGTGAAGAAGGCTCTGGAG
CTGCAGATGGAGAGTCACCGGGAGGCCCATCACCGGCAGCTGGCCCGGCTCCGGGACGAG
ATCAACGAGAAGCAGAAGACCATTGATGAGCTCAAAGACCTAAATCAGAAGCTCCAGTTA
GAGCTAGAGAAGCTTCAGGCTGACTACGAGAAGCTGAAGAGCGAAGAACACGAGAAGAGC
ACCAAGCTGCAGGAGCTGACATTTCTGTACGAGCGACATGAGCAGTCCAAGCAGGACCTC
AAGGGTCTGGAGGAGACAGTTGCCCGGGAACTCCAGACCCTCCACAACCTTCGCAAGCTG
TTCGTTCAAGACGTCACGACTCGAGTCAAGAAAAGTGCAGAAATGGAGCCCGAAGACAGT
GGGGGGATTCACTCCCAAAAGCAGAAGATTTCCTTTCTTGAGAACAACCTGGAACAGCTT
ACAAAGGTTCACAAACAGCTGGTACGTGACAATGCAGATCTGCGTTGTGAGCTTCCTAAA
TTGGAAAAACGACTTAGGGCTACGGCTGAGAGAGTTAAGGCCCTGGAGGGTGCACTGAAG
GAGGCCAAGGAGGGCGCCATGAAGGACAAGCGCCGGTACCAGCAGGAGGTGGACCGCATC
AAGGAGGCCGTTCGCTACAAGAGCTCGGGCAAACGGGGCCATTCTGCCCAGATTGCCAAA
CCCGTCCGGCCTGGCCACTACCCAGCATCCTCACCCACCAACCCCTATGGCACCCGGAGC
CCTGAGTGCATCAGTTACACCAACAGCCTCTTCCAGAACTACCAGAATCTCTACCTGCAG
GCCACACCCAGCTCCACCTCAGATATGTACTTTGCAAACTCCTGTACCAGCAGTGGAGCC
ACATCTTCTGGCGGCCCCTTGGCTTCCTACCAGAAGGCCAACATGGACAATGGAAATGCC
ACAGATATCAATGACAATAGGAGTGACCTGCCGTGTGGCTATGAGGCTGAGGACCAGGCC
AAGCTTTTCCCTCTCCACCAAGAGACAGCAGCCAGCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6323
Chromosome Location12
LocusNot Available
References
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