Activin receptor type-1

NameActivin receptor type-1
Synonyms
  • 2.7.11.30
  • Activin receptor type I
  • Activin receptor-like kinase 2
  • ACTR-I
  • ACVRLK2
  • ALK-2
  • Serine/threonine-protein kinase receptor R1
  • SKR1
  • TGF-B superfamily receptor type I
  • TSR-I
Gene NameACVR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010226|Activin receptor type-1
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
Number of residues509
Molecular Weight57152.41
Theoretical pI7.36
GO Classification
Functions
  • protein serine/threonine kinase activity
  • receptor signaling protein serine/threonine kinase activity
  • activin binding
  • transmembrane receptor protein serine/threonine kinase activity
  • activin receptor activity, type I
  • SMAD binding
  • metal ion binding
  • transforming growth factor beta binding
  • transforming growth factor beta receptor activity, type I
  • protein homodimerization activity
  • peptide hormone binding
  • ATP binding
  • protein kinase activity
Processes
  • germ cell development
  • mesoderm formation
  • mitral valve morphogenesis
  • regulation of ossification
  • negative regulation of activin receptor signaling pathway
  • negative regulation of extrinsic apoptotic signaling pathway
  • in utero embryonic development
  • negative regulation of signal transduction
  • neural crest cell migration
  • activin receptor signaling pathway
  • pathway-restricted SMAD protein phosphorylation
  • atrial septum primum morphogenesis
  • positive regulation of cell migration
  • patterning of blood vessels
  • BMP signaling pathway
  • positive regulation of transcription, DNA-templated
  • peptidyl-threonine phosphorylation
  • cardiac muscle cell fate commitment
  • cellular response to BMP stimulus
  • positive regulation of transcription from RNA polymerase II promoter
  • pharyngeal system development
  • determination of left/right symmetry
  • protein phosphorylation
  • positive regulation of bone mineralization
  • embryonic heart tube morphogenesis
  • positive regulation of determination of dorsal identity
  • endocardial cushion cell fate commitment
  • transforming growth factor beta receptor signaling pathway
  • positive regulation of osteoblast differentiation
  • G1/S transition of mitotic cell cycle
  • acute inflammatory response
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • gastrulation with mouth forming second
  • smooth muscle cell differentiation
Components
  • apical part of cell
  • integral component of plasma membrane
  • activin receptor complex
General FunctionTransmembrane receptor protein serine/threonine kinase activity
Specific FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
Pfam Domain Function
Transmembrane Regions124-146
GenBank Protein ID338219
UniProtKB IDQ04771
UniProtKB Entry NameACVR1_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010227|Activin receptor type-1 (ACVR1)
ATGGTAGATGGAGTGATGATTCTTCCTGTGCTTATCATGATTGCTCTCCCCTCCCCTAGT
ATGGAAGATGAGAAGCCCAAGGTCAACCCCAAACTCTACATGTGTGTGTGTGAAGGTCTC
TCCTGCGGTAATGAGGACCACTGTGAAGGCCAGCAGTGCTTTTCCTCACTGAGCATCAAC
GATGGCTTCCACGTCTACCAGAAAGGCTGCTTCCAGGTTTATGAGCAGGGAAAGATGACC
TGTAAGACCCCGCCGTCCCCTGGCCAAGCCGTGGAGTGCTGCCAAGGGGACTGGTGTAAC
AGGAACATCACGGCCCAGCTGCCCACTAAAGGAAAATCCTTCCCTGGAACACAGAATTTC
CACTTGGAGGTTGGCCTCATTATTCTCTCTGTAGTGTTCGCAGTATGTCTTTTAGCCTGC
CTGCTGGGAGTTGCTCTCCGAAAATTTAAAAGGCGCAACCAAGAACGCCTCAATCCCCGA
GACGTGGAGTATGGCACTATCGAAGGGCTCATCACCACCAATGTTGGAGACAGCACTTTA
GCAGATTTATTGGATCATTCGTGTACATCAGGAAGTGGCTCTGGTCTTCCTTTTCTGGTA
CAAAGAACAGTGGCTCGCCAGATTACACTGTTGGAGTGTGTCGGGAAAGGCAGGTATGGT
GAGGTGTGGAGGGGCAGCTGGCAAGGGGAGAATGTTGCCGTGAAGATCTTCTCCTCCCGT
GATGAGAAGTCATGGTTCAGGGAAACGGAATTGTACAACACTGTGATGCTGAGGCATGAA
AATATCTTAGGTTTCATTGCTTCAGACATGACATCAAGACACTCCAGTACCCAGCTGTGG
TTAATTACACATTATCATGAAATGGGATCGTTGTACGACTATCTTCAGCTTACTACTCTG
GATACAGTTAGCTGCCTTCGAATAGTGCTGTCCATAGCTAGTGGTCTTGCACATTTGCAC
ATAGAGATATTTGGGACCCAAGGGAAACCAGCCATTGCCCATCGAGATTTAAAGAGCAAA
AATATTCTGGTTAAGAAGAATGGACAGTGTTGCATAGCAGATTTGGGCCTGGCAGTCATG
CATTCCCAGAGCACCAATCAGCTTGATGTGGGGAACAATCCCCGTGTGGGCACCAAGCGC
TACATGGCCCCCGAAGTTCTAGATGAAACCATCCAGGTGGATTGTTTCGATTCTTATAAA
AGGGTCGATATTTGGGCCTTTGGACTTGTTTTGTGGGAAGTGGCCAGGCGGATGGTGAGC
AATGGTATAGTGGAGGATTACAAGCCACCGTTCTACGATGTGGTTCCCAATGACCCAAGT
TTTGAAGATATGAGGAAGGTAGTCTGTGTGGATCAACAAAGGCCAAACATACCCAACAGA
TGGTTCTCAGACCCGACATTAACCTCTCTGGCCAAGCTAATGAAAGAATGCTGGTATCAA
AATCCATCCGCAAGACTCACAGCACTGCGTATCAAAAAGACTTTGACCAAAATTGATAAT
TCCCTCGACAAATTGAAAACTGACTGTTGA
GenBank Gene IDL02911
GeneCard IDNot Available
GenAtlas IDACVR1
HGNC IDHGNC:171
Chromosome Location2
Locus2q23-q24
References
  1. Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M: A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor. J Biol Chem. 1993 Jun 15;268(17):12719-23. 8389764
  2. ten Dijke P, Ichijo H, Franzen P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene. 1993 Oct;8(10):2879-87. 8397373
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