T3DB: P2X purinoceptor 3

Name	P2X purinoceptor 3
Synonyms	ATP receptor P2X3 Purinergic receptor
Gene Name	P2RX3
Organism	Human
Amino acid sequence	>lcl\|BSEQ0013731\|P2X purinoceptor 3 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
Number of residues	397
Molecular Weight	44288.65
Theoretical pI	Not Available
GO Classification	Functions extracellular ATP-gated cation channel activity purinergic nucleotide receptor activity ATP binding Processes response to cold behavioral response to pain positive regulation of calcium-mediated signaling response to carbohydrate response to hypoxia peristalsis positive regulation of calcium ion transport into cytosol neuromuscular synaptic transmission sensory perception of taste neuronal action potential purinergic nucleotide receptor signaling pathway response to mechanical stimulus urinary bladder smooth muscle contraction protein homooligomerization transport signal transduction regulation of synaptic plasticity response to ATP response to heat Components Golgi apparatus rough endoplasmic reticulum integral component of plasma membrane membrane raft integral component of nuclear inner membrane neuronal cell body dendritic spine terminal bouton receptor complex
General Function	Purinergic nucleotide receptor activity
Specific Function	Receptor for ATP that acts as a ligand-gated ion channel.
Pfam Domain Function	P2X_receptor (PF00864 )
Transmembrane Regions	23-43 318-338
GenBank Protein ID	Not Available
UniProtKB ID	P56373
UniProtKB Entry Name	P2RX3_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0013732\|P2X purinoceptor 3 (P2RX3) ATGAACTGCATATCCGACTTCTTCACCTATGAGACCACCAAGTCGGTGGTTGTGAAGAGC TGGACCATCGGGATCATCAACCGAGTAGTTCAGCTTCTGATCATCTCCTACTTTGTAGGG TGGGTTTTCTTGCACGAGAAGGCTTACCAGGTACGGGACACAGCCATTGAGTCCTCGGTG GTAACCAAGGTGAAGGGCTCCGGACTCTACGCCAACAGAGTCATGGATGTGTCTGATTAC GTGACGCCACCTCAGGGCACCTCGGTCTTTGTCATCATCACCAAGATGATTGTTACTGAA AATCAGATGCAAGGATTCTGCCCAGAGAGTGAGGAGAAATACCGCTGTGTATCAGACAGC CAGTGCGGGCCTGAGCGCTTGCCAGGTGGGGGGATCCTCACTGGCCGCTGCGTGAACTAC AGCTCTGTGCTCCGGACCTGTGAGATCCAGGGCTGGTGCCCCACGGAGGTGGACACAGTG GAAACGCCCATCATGATGGAAGCTGAGAACTTCACTATTTTCATCAAGAACAGCATCCGT TTCCCCCTCTTCAACTTTGAGAAGGGAAACCTCCTTCCCAACCTGACAGCCAGGGACATG AAGACCTGCCGCTTCCACCCGGACAAGGACCCTTTCTGCCCCATCTTGCGGGTAGGGGAC GTGGTCAAGTTTGCGGGGCAGGATTTTGCCAAACTGGCGCGCACGGGGGGAGTTCTGGGC ATTAAGATCGGCTGGGTGTGCGACTTGGACAAGGCCTGGGACCAGTGCATCCCCAAATAC TCCTTCACCCGGCTCGACAGCGTTTCTGAGAAAAGCAGCGTGTCCCCAGGCTACAACTTC AGGTTTGCCAAGTACTACAAAATGGAAAATGGCAGTGAGTACCGCACCCTCCTGAAGGCT TTTGGCATCCGCTTCGACGTGCTGGTATACGGGAATGCTGGCAAGTTCAACATCATCCCC ACCATCATCAGCTCTGTGGCGGCCTTTACTTCTGTGGGAGTGGGAACTGTTCTCTGTGAC ATCATCCTGCTCAACTTCCTCAAGGGGGCCGACCAGTACAAAGCCAAGAAGTTTGAGGAG GTGAATGAGACTACGCTGAAAATCGCGGCTTTGACCAACCCAGTGTACCCCAGCGACCAG ACCACAGCGGAGAAGCAGTCCACCGATTCGGGGGCCTTCTCCATAGGCCACTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:8534
Chromosome Location	11
Locus	Not Available
References	Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stuhmer W: Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol Pharmacol. 1997 Jan;51(1):109-18. 9016352 Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. 16554811 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334