Oxysterols receptor LXR-beta

NameOxysterols receptor LXR-beta
Synonyms
  • Liver X receptor beta
  • LXRB
  • NER
  • Nuclear receptor NER
  • Nuclear receptor subfamily 1 group H member 2
  • Ubiquitously-expressed nuclear receptor
  • UNR
Gene NameNR1H2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037145|Oxysterols receptor LXR-beta
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Number of residues460
Molecular Weight50973.375
Theoretical pI7.8
GO Classification
Functions
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • ATPase binding
  • apolipoprotein A-I receptor binding
  • zinc ion binding
  • steroid hormone receptor activity
  • RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
  • DNA binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Processes
  • negative regulation of transcription, DNA-templated
  • transcription initiation from RNA polymerase II promoter
  • retinoic acid receptor signaling pathway
  • positive regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of proteolysis
  • negative regulation of lipid transport
  • positive regulation of cellular protein metabolic process
  • positive regulation of fatty acid biosynthetic process
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of lipoprotein lipase activity
  • negative regulation of interferon-gamma-mediated signaling pathway
  • cellular lipid metabolic process
  • cholesterol homeostasis
  • regulation of cholesterol homeostasis
  • negative regulation of cholesterol storage
  • negative regulation of pinocytosis
  • negative regulation of macrophage derived foam cell differentiation
  • positive regulation of cholesterol transport
  • positive regulation of cholesterol efflux
  • positive regulation of high-density lipoprotein particle assembly
  • positive regulation of triglyceride biosynthetic process
  • positive regulation of pancreatic juice secretion
  • positive regulation of lipid storage
  • positive regulation of secretion of lysosomal enzymes
  • gene expression
Components
  • nucleoplasm
  • cytoplasm
  • nucleus
General FunctionZinc ion binding
Specific FunctionNuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID641962
UniProtKB IDP55055
UniProtKB Entry NameNR1H2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021844|Oxysterols receptor LXR-beta (NR1H2)
ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG
CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG
GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG
GGCGTCCTTTCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAACAGCAGCAGGAG
TCACAGTCACAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGG
CCTGGGGCTTCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGT
GTCCAGCTAACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAG
TGCAACAAACGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGAC
CCCCAGTCCCGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATC
TCAGTCCAGGAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGG
GAGGACCAGATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCC
AGGCGCTACAACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAG
GACGACTTCCACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCG
CGGGCCATGCGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAAC
ATCTTCTCGGCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAG
CCCTACGTGGAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGC
TTCCCGCGCATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAG
CAGGTCTTCGCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGG
GACGTCCACGAGTGA
GenBank Gene IDU07132
GeneCard IDNot Available
GenAtlas IDNR1H2
HGNC IDHGNC:7965
Chromosome Location19
Locus19q13.3-19q13.3
References
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