
Lysine-specific demethylase 5C
| Name | Lysine-specific demethylase 5C |
|---|---|
| Synonyms |
|
| Gene Name | KDM5C |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0037293|Lysine-specific demethylase 5C MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG AGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSH SPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTEL VEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMP VLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSL AAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRA YHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDL NLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALA CYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVA LEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGP HRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGL LQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASV APSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQ ALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHS WREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDL RDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGAL QCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILA LLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPR PEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSL LPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLEL EKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEE ETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL |
| Number of residues | 1560 |
| Molecular Weight | 175718.565 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
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| General Function | Zinc ion binding |
| Specific Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
| Pfam Domain Function | |
| Transmembrane Regions | Not Available |
| GenBank Protein ID | Not Available |
| UniProtKB ID | P41229 |
| UniProtKB Entry Name | KDM5C_HUMAN |
| Cellular Location | Nucleus |
| Gene sequence | >lcl|BSEQ0021734|Lysine-specific demethylase 5C (KDM5C) ATGGAGCCGGGGTCCGACGATTTCCTACCGCCACCGGAGTGCCCGGTGTTCGAGCCTAGC TGGGCCGAGTTCCGAGACCCTCTTGGCTACATCGCGAAAATCAGGCCCATCGCAGAGAAA TCGGGCATTTGCAAGATCCGCCCACCCGCGATTGTGGTGGAGGAAGGTGGTTATGAAGCT ATCTGCAAGGACCGTCGGTGGGCTCGGGTAGCCCAGCGCCTCAACTATCCACCAGGCAAA AATATTGGCTCCTTGCTACGCTCCCACTACGAACGCATTGTTTATCCCTATGAAATGTAC CAGTCTGGAGCCAACCTTGTGCAGTGTAACACACGTCCATTTGATAATGAGGAGAAGGAC AAGGAATACAAACCCCACAGCATCCCCCTACGACAGTCTGTGCAGCCTTCCAAGTTCAAC AGCTATGGCCGGCGGGCCAAGAGACTGCAGCCTGATCCGGAACCCACAGAGGAAGACATT GAGAAGAATCCAGAGCTGAAAAAGCTACAGATCTATGGGGCAGGCCCCAAGATGATGGGC CTGGGCCTCATGGCCAAAGACAAGACTCTGCGGAAGAAAGATAAGGAGGGGCCTGAGTGT CCCCCCACAGTAGTGGTGAAGGAGGAGTTAGGTGGGGATGTGAAGGTGGAGTCAACATCG CCTAAGACCTTCCTGGAGAGCAAGGAGGAGCTGAGTCACAGCCCAGAACCCTGCACCAAG ATGACCATGAGGCTACGGAGGAACCACAGCAATGCCCAGTTTATTGAGTCATATGTCTGC CGGATGTGTTCTCGAGGGGATGAGGATGACAAGCTCCTGCTGTGTGATGGCTGTGATGAC AACTACCACATCTTCTGCCTGCTGCCTCCTCTGCCTGAGATCCCCAAGGGTGTCTGGCGG TGCCCAAAGTGTGTCATGGCGGAGTGTAAGCGGCCCCCAGAAGCCTTTGGCTTTGAGCAG GCTACCCGGGAATACACTCTGCAGAGCTTTGGCGAGATGGCCGACTCCTTTAAAGCTGAC TACTTCAACATGCCCGTGCATATGGTGCCCACAGAACTTGTGGAGAAGGAGTTCTGGAGG CTGGTAAATAGCATTGAGGAAGATGTGACTGTTGAGTATGGAGCTGACATCCATTCCAAA GAATTTGGCAGCGGTTTCCCTGTCAGTGACAGTAAACGGCACCTAACCCCCGAAGAGGAG GAGTATGCTACCAGTGGTTGGAACCTAAATGTGATGCCGGTGTTGGAACAGTCTGTACTG TGCCACATCAATGCAGATATCTCTGGCATGAAGGTGCCCTGGCTCTACGTGGGCATGGTC TTCTCAGCCTTTTGCTGGCATATTGAGGATCACTGGAGTTACTCCATTAACTACCTCCAC TGGGGTGAGCCGAAGACCTGGTATGGGGTGCCCTCACTTGCAGCAGAACATTTGGAAGAA GTGATGAAGAAGCTGACACCTGAACTATTTGATAGCCAGCCTGACCTCCTGCACCAACTT GTCACCCTCATGAATCCCAACACCCTCATGTCCCATGGTGTGCCAGTTGTCCGCACAAAC CAGTGTGCAGGAGAGTTTGTCATCACCTTCCCCCGTGCTTACCACAGCGGCTTCAACCAA GGCTACAACTTTGCCGAGGCTGTCAACTTTTGCACTGCTGACTGGTTGCCTGCTGGGCGC CAGTGCATTGAGCACTACCGCCGGCTCCGGAGATACTGCGTCTTCTCCCATGAGGAGCTT ATCTGCAAGATGGCTGCCTGCCCAGAGAAGCTAGACCTGAACCTGGCGGCAGCTGTGCAT AAGGAGATGTTCATCATGGTGCAAGAAGAGCGGCGTCTACGAAAGGCCCTGCTGGAGAAG GGTATCACAGAGGCTGAGCGAGAGGCTTTCGAGCTGCTCCCAGATGATGAGCGCCAGTGT ATCAAGTGCAAGACTACGTGTTTCCTGTCAGCCCTGGCCTGCTACGACTGCCCAGACGGC CTTGTCTGCCTTTCCCACATCAATGATCTCTGCAAGTGCTCCAGTAGCCGGCAGTACCTG CGGTATCGGTATACCTTGGATGAGCTTCCTGCCATGCTGCATAAGCTGAAGGTTCGGGCT GAGTCCTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCCTGGAGGTGGAGGATGGGCGG AAGCGCAGCCTTGAAGAACTGAGGGCACTAGAGTCTGAAGCCCGTGAGCGGAGGTTTCCT AATAGTGAGCTGCTGCAGCAACTAAAGAACTGCCTGAGTGAGGCAGAGGCTTGCGTGTCC CGAGCTCTGGGACTGGTCAGCGGCCAGGAAGCTGGCCCCCACAGGGTGGCTGGTCTACAG ATGACCCTGACTGAGCTCCGGGCCTTTCTGGACCAGATGAACAACCTGCCTTGCGCCATG CACCAGATTGGGGATGTCAAGGGTGTTCTGGAACAGGTGGAGGCCTACCAGGCTGAGGCT CGTGAGGCCCTGGCCTCACTGCCCTCCAGTCCAGGGCTACTGCAGTCCCTGTTGGAGAGG GGGCGGCAGCTGGGGGTGGAGGTGCCTGAGGCCCAGCAGCTCCAGCGGCAGGTGGAACAG GCGCGATGGCTGGATGAGGTGAAACGCACACTGGCCCCCTCAGCCCGAAGGGGCACCTTG GCTGTCATGCGAGGACTGTTGGTCGCGGGTGCCAGTGTAGCCCCTAGCCCTGCTGTGGAT AAAGCCCAGGCCGAGCTGCAGGAACTGCTGACCATTGCTGAACGCTGGGAGGAGAAAGCC CACCTCTGCCTGGAGGCCAGGCAGAAGCATCCACCAGCCACACTTGAGGCCATAATCCGT GAAGCGGAAAACATCCCTGTTCACCTGCCCAACATCCAGGCTCTCAAGGAGGCTCTTGCT AAGGCCCGGGCCTGGATTGCTGATGTTGATGAGATCCAAAATGGTGACCACTACCCCTGC CTGGATGACTTGGAGGGCCTAGTAGCTGTGGGCCGGGACCTACCTGTGGGGCTGGAGGAG CTGAGACAGCTAGAGCTACAGGTACTGACAGCGCACTCCTGGAGGGAGAAGGCCTCCAAG ACCTTCCTCAAGAAAAATTCTTGCTACACGCTGCTGGAGGTTCTCTGCCCATGTGCAGAT GCCGGCTCAGACAGCACCAAGCGCAGCCGGTGGATGGAGAAGGAGCTGGGGTTGTACAAA TCTGACACAGAGCTGCTGGGGCTGTCTGCGCAGGACCTCAGGGACCCAGGCTCTGTGATC GTGGCCTTCAAGGAGGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACC AATTCGGCCAAGCCCAGTCCACTGGCATCATCGAGCACGGCCTCCTCTACAACCTCTATC TGTGTGTGTGGGCAGGTGCTGGCTGGGGCGGGAGCTCTGCAGTGTGACCTGTGTCAGGAC TGGTTCCATGGGCGGTGTGTGTCAGTGCCTCGCCTCCTCAGCTCTCCGAGGCCCAATCCC ACCTCATCCCCACTGCTGGCCTGGTGGGAATGGGACACCAAATTCCTGTGTCCACTGTGT ATGCGCTCAAGGCGCCCGCGCCTGGAGACCATCCTGGCACTGCTGGTAGCCCTGCAGAGA CTGCCTGTGCGGCTGCCCGAGGGCGAGGCCCTGCAGTGCCTCACAGAGAGGGCCATCAGC TGGCAAGGCCGCGCCAGGCAGGCTCTGGCCTCTGAAGATGTGACTGCTCTTTTGGGACGG CTGGCTGAGCTCCGCCAACGGCTACAGGCTGAACCTAGACCTGAGGAGCCTCCTAACTAC CCTGCAGCCCCTGCTTCTGACCCCCTCAGAGAGGGCAGTGGCAAGGATATGCCTAAGGTC CAGGGCTTACTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAAGGTAGCCCCGGAGGAG GGCTCAGATCTGGAGCTGCTGTCCTCGCTGTTGCCACAGTTGACTGGCCCTGTGTTGGAA CTGCCTGAGGCAACCCGGGCCCCCTTGGAGGAGCTCATGATGGAGGGGGACCTGCTCGAG GTGACCCTGGATGAGAACCACAGCATCCCTGAGTCCCTTGACTTTTGTATTCTGACTCCA AGGTATTGTTCAGACCTCAGCTCCTGGGGGCCGGCCCCTGGAGTCTTCCCTCCCTGGTAG |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:11114 |
| Chromosome Location | X |
| Locus | Not Available |
| References |
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