Nociceptin receptor

NameNociceptin receptor
Synonyms
  • Kappa-type 3 opioid receptor
  • KOR-3
  • OOR
  • ORL1
  • Orphanin FQ receptor
Gene NameOPRL1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004671|Nociceptin receptor
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
Number of residues370
Molecular Weight40692.775
Theoretical pI8.43
GO Classification
Functions
  • nociceptin receptor activity
  • G-protein coupled receptor activity
  • neuropeptide binding
Processes
  • opioid receptor signaling pathway
  • sensory perception
  • estrous cycle
  • positive regulation of cytosolic calcium ion concentration
  • positive regulation of urine volume
  • positive regulation of protein phosphorylation
  • locomotor rhythm
  • response to estradiol
  • positive regulation of gastric acid secretion
  • sensory perception of pain
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • negative regulation of blood pressure
  • regulation of sensory perception of pain
  • negative regulation of cAMP biosynthetic process
  • negative regulation of voltage-gated calcium channel activity
  • neuropeptide signaling pathway
  • eating behavior
  • synaptic transmission
Components
  • cytosol
  • integral component of plasma membrane
  • neuron projection
  • cytoplasmic membrane-bounded vesicle
  • plasma membrane
General FunctionNociceptin receptor activity
Specific FunctionG-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Pfam Domain Function
Transmembrane Regions49-74 88-109 125-146 166-188 212-236 265-285 301-322
GenBank Protein IDNot Available
UniProtKB IDP41146
UniProtKB Entry NameOPRX_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016773|Nociceptin receptor (OPRL1)
ATGGAGCCCCTCTTCCCCGCGCCGTTCTGGGAGGTTATCTACGGCAGCCACCTTCAGGGC
AACCTGTCCCTCCTGAGCCCCAACCACAGTCTGCTGCCCCCGCATCTGCTGCTCAATGCC
AGCCACGGCGCCTTCCTGCCCCTCGGGCTCAAGGTCACCATCGTGGGGCTCTACCTGGCC
GTGTGTGTCGGAGGGCTCCTGGGGAACTGCCTTGTCATGTACGTCATCCTCAGGCACACC
AAAATGAAGACAGCCACCAATATTTACATCTTTAACCTGGCCCTGGCCGACACTCTGGTC
CTGCTGACGCTGCCCTTCCAGGGCACGGACATCCTCCTGGGCTTCTGGCCGTTTGGGAAT
GCGCTGTGCAAGACAGTCATTGCCATTGACTACTACAACATGTTCACCAGCACCTTCACC
CTAACTGCCATGAGTGTGGATCGCTATGTAGCCATCTGCCACCCCATCCGTGCCCTCGAC
GTCCGCACGTCCAGCAAAGCCCAGGCTGTCAATGTGGCCATCTGGGCCCTGGCCTCTGTT
GTCGGTGTTCCCGTTGCCATCATGGGCTCGGCACAGGTCGAGGATGAAGAGATCGAGTGC
CTGGTGGAGATCCCTACCCCTCAGGATTACTGGGGCCCGGTGTTTGCCATCTGCATCTTC
CTCTTCTCCTTCATCGTCCCCGTGCTCGTCATCTCTGTCTGCTACAGCCTCATGATCCGG
CGGCTCCGTGGAGTCCGCCTGCTCTCGGGCTCCCGAGAGAAGGACCGGAACCTGCGGCGC
ATCACTCGGCTGGTGCTGGTGGTAGTGGCTGTGTTCGTGGGCTGCTGGACGCCTGTCCAG
GTCTTCGTGCTGGCCCAAGGGCTGGGGGTTCAGCCGAGCAGCGAGACTGCCGTGGCCATT
CTGCGCTTCTGCACGGCCCTGGGCTACGTCAACAGCTGCCTCAACCCCATCCTCTACGCC
TTCCTGGATGAGAACTTCAAGGCCTGCTTCCGCAAGTTCTGCTGTGCATCTGCCCTGCGC
CGGGACGTGCAGGTGTCTGACCGCGTGCGCAGCATTGCCAAGGACGTGGCCCTGGCCTGC
AAGACCTCTGAGACGGTACCGCGGCCCGCATGA
GenBank Gene IDX77130
GeneCard IDNot Available
GenAtlas IDOPRL1
HGNC IDHGNC:8155
Chromosome Location20
Locus20q13.33
References
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  2. Serhan CN, Fierro IM, Chiang N, Pouliot M: Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. J Immunol. 2001 Mar 15;166(6):3650-4. 11238602
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  5. Wick MJ, Minnerath SR, Roy S, Ramakrishnan S, Loh HH: Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Brain Res Mol Brain Res. 1995 Sep;32(2):342-7. 7500847
  6. Spampinato S, Di Toro R, Alessandri M, Murari G: Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells. Cell Mol Life Sci. 2002 Dec;59(12):2172-83. 12568343
  7. Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Chang SD, Baird MA, Cao YQ, Bruchas MR: Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. J Biol Chem. 2012 Dec 7;287(50):42019-30. doi: 10.1074/jbc.M112.405696. Epub 2012 Oct 19. 23086955
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