Melanocortin receptor 5

NameMelanocortin receptor 5
Synonyms
  • MC-2
  • MC5-R
Gene NameMC5R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013949|Melanocortin receptor 5
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
Number of residues325
Molecular Weight36600.21
Theoretical pINot Available
GO Classification
Functions
  • melanocortin receptor activity
  • hormone binding
Processes
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • positive regulation of cAMP biosynthetic process
Components
  • plasma membrane
  • integral component of plasma membrane
General FunctionMelanocortin receptor activity
Specific FunctionReceptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Pfam Domain Function
Transmembrane Regions38-61 74-97 115-138 156-179 187-211 240-265 274-297
GenBank Protein IDNot Available
UniProtKB IDP33032
UniProtKB Entry NameMC5R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013950|Melanocortin receptor 5 (MC5R)
ATGAATTCCTCATTTCACCTGCATTTCTTGGATCTCAACCTGAATGCCACAGAGGGCAAC
CTTTCAGGACCCAATGTCAAAAACAAGTCTTCACCATGTGAAGACATGGGCATTGCTGTG
GAGGTGTTTCTCACTCTGGGTGTCATCAGCCTCTTGGAGAACATCTTGGTCATAGGGGCC
ATAGTGAAGAACAAAAACCTGCACTCCCCCATGTACTTCTTCGTGTGCAGCCTGGCAGTG
GCGGACATGCTGGTGAGCATGTCCAGTGCCTGGGAGACCATCACCATCTACCTACTCAAC
AACAAGCACCTAGTGATAGCAGACGCCTTTGTGCGCCACATTGACAATGTGTTTGACTCC
ATGATCTGCATTTCCGTGGTGGCATCCATGTGCAGCTTACTGGCCATTGCAGTGGATAGG
TACGTCACCATCTTCTACGCCCTGCGCTACCACCACATCATGACGGCGAGGCGCTCAGGG
GCCATCATCGCCGGCATCTGGGCTTTCTGCACGGGCTGCGGCATTGTCTTCATCCTGTAC
TCAGAATCCACCTACGTCATCCTGTGCCTCATCTCCATGTTCTTCGCTATGCTGTTCCTC
CTGGTGTCTCTGTACATACACATGTTCCTCCTGGCGCGGACTCACGTCAAGCGGATCGCG
GCTCTGCCCGGGGCCAGCTCTGCGCGGCAGAGGACCAGCATGCAGGGCGCGGTCACCGTC
ACCATGCTGCTGGGCGTGTTTACCGTGTGCTGGGCCCCGTTCTTCCTTCATCTCACTTTA
ATGCTTTCTTGCCCTCAGAACCTCTACTGCTCTCGCTTCATGTCTCACTTCAATATGTAC
CTCATACTCATCATGTGTAATTCCGTGATGGACCCTCTCATATATGCCTTCCGCAGCCAA
GAGATGCGGAAGACCTTTAAGGAGATTATTTGCTGCCGTGGTTTCAGGATCGCCTGCAGC
TTTCCCAGAAGGGATTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6933
Chromosome Location18
LocusNot Available
References
  1. Chhajlani V, Muceniece R, Wikberg JE: Molecular cloning of a novel human melanocortin receptor. Biochem Biophys Res Commun. 1993 Sep 15;195(2):866-73. 8396929
  2. Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P: Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1007-14. 8179577
  3. Fathi Z, Iben LG, Parker EM: Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem Res. 1995 Jan;20(1):107-13. 7739752
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  5. Frandberg PA, Xu X, Chhajlani V: Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH. Biochem Biophys Res Commun. 1997 Jul 18;236(2):489-92. 9240466
  6. Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL: Expression, candidate gene, and population studies of the melanocortin 5 receptor. J Invest Dermatol. 2001 Apr;116(4):564-70. 11286624