Mitogen-activated protein kinase 4

NameMitogen-activated protein kinase 4
Synonyms
  • 2.7.11.24
  • ERK-4
  • ERK4
  • Extracellular signal-regulated kinase 4
  • MAP kinase 4
  • MAP kinase isoform p63
  • p63-MAPK
  • PRKM4
Gene NameMAPK4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008788|Mitogen-activated protein kinase 4
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK
HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT
LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS
HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL
ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR
LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS
LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF
EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG
AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD
VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
Number of residues587
Molecular Weight65921.01
Theoretical pINot Available
GO Classification
Functions
  • protein kinase binding
  • ATP binding
  • protein serine/threonine kinase activity
  • MAP kinase activity
  • protein homodimerization activity
Processes
  • cell cycle
  • MAPK cascade
  • protein phosphorylation
Components
  • cytoplasm
  • nucleus
  • cytosol
  • nucleoplasm
General FunctionProtein serine/threonine kinase activity
Specific FunctionAtypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP31152
UniProtKB Entry NameMK04_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013414|Mitogen-activated protein kinase 4 (MAPK4)
ATGTGGGCCGCCGGCTGCATCCTGGCTGAGATGCTTACGGGGAGAATGCTCTTTGCTGGG
GCCCATGAGCTGGAGCAGATGCAACTCATCCTGGAGACCATCCCTGTAATCCGGGAGGAA
GACAAGGACGAGCTGCTCAGGGTGATGCCTTCCTTTGTCAGCAGCACCTGGGAGGTGAAG
AGGCCTCTGCGCAAGCTGCTCCCTGAAGTGAACAGTGAAGCCATCGACTTTCTGGAGAAG
ATCCTGACCTTTAACCCCATGGATCGCCTAACAGCTGAGATGGGGCTGCAACACCCCTAC
ATGAGCCCATACTCGTGCCCTGAGGACGAGCCCACCTCACAACACCCCTTCCGCATTGAG
GATGAGATCGACGACATCGTGCTGATGGCCGCTAACCAGAGCCAGCTGTCCAACTGGGAC
ACGTGCAGTTCCAGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGG
TGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAG
GACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAG
TCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAG
GTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTAC
TCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCC
ACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTG
GAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCC
GACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGC
GGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACC
AAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAG
CACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6878
Chromosome Location18
LocusNot Available
References
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