Type-1 angiotensin II receptor

NameType-1 angiotensin II receptor
Synonyms
  • AGTR1A
  • AGTR1B
  • Angiotensin II type-1 receptor
  • AT1
  • AT1AR
  • AT1BR
  • AT2R1
  • AT2R1B
Gene NameAGTR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009910|Type-1 angiotensin II receptor
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
Number of residues359
Molecular Weight41060.53
Theoretical pI9.71
GO Classification
Functions
  • angiotensin type I receptor activity
  • bradykinin receptor binding
  • protein heterodimerization activity
  • angiotensin type II receptor activity
Processes
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • positive regulation of cellular protein metabolic process
  • positive regulation of cholesterol esterification
  • positive regulation of cytosolic calcium ion concentration
  • regulation of cell proliferation
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
  • positive regulation of inflammatory response
  • G-protein coupled receptor signaling pathway
  • positive regulation of macrophage derived foam cell differentiation
  • positive regulation of reactive oxygen species metabolic process
  • positive regulation of NAD(P)H oxidase activity
  • positive regulation of phospholipase A2 activity
  • regulation of blood vessel size by renin-angiotensin
  • regulation of inflammatory response
  • angiotensin-activated signaling pathway
  • regulation of renal sodium excretion
  • calcium-mediated signaling
  • regulation of systemic arterial blood pressure by renin-angiotensin
  • cell chemotaxis
  • regulation of vasodilation
  • kidney development
  • renin-angiotensin regulation of aldosterone production
  • low-density lipoprotein particle remodeling
  • regulation of cell growth
  • Rho protein signal transduction
  • phospholipase C-activating angiotensin-activated signaling pathway
  • regulation of vasoconstriction
Components
  • integral component of membrane
  • cytosol
  • integral component of plasma membrane
  • intracellular
  • plasma membrane
General FunctionProtein heterodimerization activity
Specific FunctionReceptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Pfam Domain Function
Transmembrane Regions28-52 65-87 103-124 143-162 193-214 241-262 276-296
GenBank Protein ID179122
UniProtKB IDP30556
UniProtKB Entry NameAGTR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0009911|Type-1 angiotensin II receptor (AGTR1)
ATGATTCTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGATTGTCCCAAA
GCTGGAAGGCATAATTACATATTTGTCATGATTCCTACTTTATACAGTATCATCTTTGTG
GTGGGAATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATATGAAGCTGAAG
ACTGTGGCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTTTTTACTGACT
TTGCCACTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGGCAATTACCTA
TGTAAGATTGCTTCAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTTTCTACTCACG
TGTCTCAGCATTGATCGATACCTGGCTATTGTTCACCCAATGAAGTCCCGCCTTCGACGC
ACAATGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGGCTTGGCCAGT
TTGCCAGCTATAATCCATCGAAATGTATTTTTCATTGAGAACACCAATATTACAGTTTGT
GCTTTCCATTATGAGTCCCAAAATTCAACCCTCCCGATAGGGCTGGGCCTGACCAAAAAT
ATACTGGGTTTCCTGTTTCCTTTTCTGATCATTCTTACAAGTTATACTCTTATTTGGAAG
GCCCTAAAGAAGGCTTATGAAATTCAGAAGAACAAACCAAGAAATGATGATATTTTTAAG
ATAATTATGGCAATTGTGCTTTTCTTTTTCTTTTCCTGGATTCCCCACCAAATATTCACT
TTTCTGGATGTATTGATTCAACTAGGCATCATACGTGACTGTAGAATTGCAGATATTGTG
GACACGGCCATGCCTATCACCATTTGTATAGCTTATTTTAACAATTGCCTGAATCCTCTT
TTTTATGGCTTTCTGGGGAAAAAATTTAAAAGATATTTTCTCCAGCTTCTAAAATATATT
CCCCCAAAAGCCAAATCCCACTCAAACCTTTCAACAAAAATGAGCACGCTTTCCTACCGC
CCCTCAGATAATGTAAGCTCATCCACCAAGAAGCCTGCACCATGTTTTGAGGTTGAGTGA
GenBank Gene IDM91464
GeneCard IDNot Available
GenAtlas IDAGTR1
HGNC IDHGNC:336
Chromosome Location3
Locus3q21-q25
References
  1. Mauzy CA, Hwang O, Egloff AM, Wu LH, Chung FZ: Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor. Biochem Biophys Res Commun. 1992 Jul 15;186(1):277-84. 1378723
  2. Furuta H, Guo DF, Inagami T: Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992 Feb 28;183(1):8-13. 1543512
  3. Bergsma DJ, Ellis C, Kumar C, Nuthulaganti P, Kersten H, Elshourbagy N, Griffin E, Stadel JM, Aiyar N: Cloning and characterization of a human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992 Mar 31;183(3):989-95. 1567413
  4. Takayanagi R, Ohnaka K, Sakai Y, Nakao R, Yanase T, Haji M, Inagami T, Furuta H, Gou DF, Nakamuta M, et al.: Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. Biochem Biophys Res Commun. 1992 Mar 16;183(2):910-6. 1550596
  5. Curnow KM, Pascoe L, White PC: Genetic analysis of the human type-1 angiotensin II receptor. Mol Endocrinol. 1992 Jul;6(7):1113-8. 1508224
  6. Konishi H, Kuroda S, Inada Y, Fujisawa Y: Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression. Biochem Biophys Res Commun. 1994 Mar 15;199(2):467-74. 8135787
  7. Nawata H, Takayanagi R, Ohnaka K, Sakai Y, Imasaki K, Yanase T, Ikuyama S, Tanaka S, Ohe K: Type 1 angiotensin II receptors of adrenal tumors. Steroids. 1995 Jan;60(1):28-34. 7792812
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