Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

NameSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms
  • Medium tumor antigen-associated 61 kDa protein
  • PP2A subunit A isoform PR65-alpha
  • PP2A subunit A isoform R1-alpha
Gene NamePPP2R1A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012619|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Number of residues589
Molecular Weight65307.81
Theoretical pI4.75
GO Classification
Functions
  • protein phosphatase type 2A regulator activity
  • protein serine/threonine phosphatase activity
  • antigen binding
  • protein heterodimerization activity
Processes
  • mitotic cell cycle
  • meiotic spindle elongation
  • organelle organization
  • regulation of growth
  • mitotic nuclear envelope reassembly
  • protein dephosphorylation
  • regulation of DNA replication
  • mitotic sister chromatid separation
  • negative regulation of cell growth
  • regulation of cell adhesion
  • negative regulation of tyrosine phosphorylation of Stat3 protein
  • response to organic substance
  • regulation of cell differentiation
  • peptidyl-serine dephosphorylation
  • chromosome segregation
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • second-messenger-mediated signaling
  • regulation of meiotic cell cycle process involved in oocyte maturation
  • protein complex assembly
  • regulation of protein phosphatase type 2A activity
  • gene expression
  • regulation of Wnt signaling pathway
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • RNA splicing
  • regulation of transcription, DNA-templated
  • ceramide metabolic process
  • apoptotic process
  • female meiotic division
  • fibroblast growth factor receptor signaling pathway
  • inactivation of MAPK activity
  • G2/M transition of mitotic cell cycle
  • meiotic sister chromatid cohesion, centromeric
Components
  • nucleus
  • protein phosphatase type 2A complex
  • chromosome, centromeric region
  • cytosol
  • extracellular exosome
  • mitochondrion
  • membrane
  • microtubule cytoskeleton
General FunctionProtein serine/threonine phosphatase activity
Specific FunctionThe PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178663
UniProtKB IDP30153
UniProtKB Entry Name2AAA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012620|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)
ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTC
CGCAATGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAGCTGTCCACCATCGCCTTG
GCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAGATACCATCTAT
GATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTTCACTACCCTGGTG
GGAGGCCCAGAGTACGTGCACTGCCTGCTGCCACCGCTGGAGTCGCTGGCCACAGTGGAG
GAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGGCCATCTCACACGAGCACTCG
CCCTCTGACCTGGAGGCGCACTTTGTGCCGCTAGTGAAGCGGCTGGCGGGCGGCGACTGG
TTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCTCCGTCTGCTACCCCCGAGTGTCCAGT
GCTGTGAAGGCGGAACTTCGACAGTACTTCCGGAACCTGTGCTCAGATGACACCCCCATG
GTGCGGCGGGCCGCAGCCTCCAAGCTGGGGGAGTTTGCCAAGGTGCTGGAGCTGGACAAC
GTCAAGAGTGAGATCATCCCCATGTTCTCCAACCTGGCCTCTGACGAGCAGGACTCGGTG
CGGCTGCTGGCGGTGGAGGCGTGCGTGAACATCGCCCAGCTTCTGCCCCAGGAGGATCTG
GAGGCCCTGGTGATGCCCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGC
TACATGGTGGCTGACAAGTTCACAGAGCTCCAGAAAGCAGTGGGGCCTGAGATCACCAAG
ACAGACCTGGTCCCTGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCC
GCAGCCTCCCACAAGGTCAAAGAGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAAT
GTGATCATGTCCCAGATCTTGCCCTGCATCAAGGAGCTGGTGTCCGATGCCAACCAACAT
GTCAAGTCTGCCCTGGCCTCAGTCATCATGGGTCTCTCTCCCATCTTGGGCAAAGACAAC
ACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAGTGCCCTGAGGTA
CGGCTGAACATCATCTCTAACCTGGACTGTGTGAACGAGGTGATTGGCATCCGGCAGCTG
TCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAAGTGGCGGGTGCGG
CTGGCCATCATTGAGTACATGCCCCTCCTGGCTGGACAGCTGGGAGTGGAGTTCTTTGAT
GAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCATGTATATGCCATCCGCGAG
GCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGTTTGGGAAGGAGTGGGCCCATGCC
ACAATCATCCCCAAGGTCTTGGCCATGTCCGGAGACCCCAACTACCTGCACCGCATGACT
ACGCTCTTCTGCATCAATGTGCTGTCTGAGGTCTGTGGGCAGGACATCACCACCAAGCAC
ATGCTACCCACGGTTCTGCGCATGGCTGGGGACCCGGTTGCCAATGTCCGCTTCAATGTG
GCCAAGTCTCTGCAGAAGATAGGGCCCATCCTGGACAACAGCACCTTGCAGAGTGAAGTC
AAGCCCATCCTAGAGAAGCTGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAG
GAGGCTCTGACTGTTCTGTCTCTCGCCTGA
GenBank Gene IDM31786
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9302
Chromosome Location19
Locus19q13.41
References
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