Neuromedin-K receptor

NameNeuromedin-K receptor
Synonyms
  • Neurokinin B receptor
  • NK-3 receptor
  • NK-3R
  • NK3R
  • NKR
  • TAC3R
  • Tachykinin receptor 3
Gene NameTACR3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016769|Neuromedin-K receptor
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
Number of residues465
Molecular Weight52201.35
Theoretical pI9.61
GO Classification
Functions
  • tachykinin receptor activity
Processes
  • positive regulation of blood pressure
  • regulation of feeding behavior
  • response to morphine
  • regulation of dopamine metabolic process
  • hyperosmotic salinity response
  • positive regulation of uterine smooth muscle contraction
  • response to estradiol
  • response to cocaine
  • positive regulation of heart rate
  • aging
  • tachykinin receptor signaling pathway
Components
  • dendrite membrane
  • neuronal cell body membrane
  • cytoplasm
  • nucleus
  • plasma membrane
  • integral component of plasma membrane
General FunctionTachykinin receptor activity
Specific FunctionThis is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Pfam Domain Function
Transmembrane Regions85-107 118-139 160-181 202-222 246-270 300-321 335-359
GenBank Protein IDNot Available
UniProtKB IDP29371
UniProtKB Entry NameNK3R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016770|Neuromedin-K receptor (TACR3)
ATGGCCACTCTCCCAGCAGCAGAAACCTGGATAGACGGGGGTGGAGGCGTGGGTGCAGAC
GCCGTGAACCTGACCGCCTCGCTAGCTGCCGGGGCGGCCACGGGGGCAGTTGAGACTGGG
TGGCTGCAACTGCTGGACCAAGCTGGCAACCTCTCCTCCTCCCCTTCCGCGCTGGGACTG
CCTGTGGCTTCCCCCGCGCCCTCCCAGCCCTGGGCCAACCTCACCAACCAGTTCGTGCAG
CCGTCCTGGCGCATCGCGCTCTGGTCCCTGGCGTATGGTGTGGTGGTGGCAGTGGCAGTT
TTGGGAAATCTCATCGTCATCTGGATCATCCTGGCCCACAAGCGCATGAGGACTGTCACC
AACTACTTCCTTGTGAACCTGGCTTTCTCCGACGCCTCCATGGCCGCCTTCAACACGTTG
GTCAATTTCATCTACGCGCTTCATAGCGAGTGGTACTTTGGCGCCAACTACTGCCGCTTC
CAGAACTTCTTTCCTATCACAGCTGTGTTCGCCAGCATCTACTCCATGACGGCCATTGCG
GTGGACAGGTATATGGCTATTATTGATCCCTTGAAACCCAGACTGTCTGCTACAGCAACC
AAGATTGTCATTGGAAGTATTTGGATTCTAGCATTTCTACTTGCCTTCCCTCAGTGTCTT
TATTCCAAAACCAAAGTCATGCCAGGCCGTACTCTCTGCTTTGTGCAATGGCCAGAAGGT
CCCAAACAACATTTCACTTACCATATTATCGTCATTATACTGGTGTACTGTTTCCCATTG
CTCATCATGGGTATTACATACACCATTGTTGGAATTACTCTCTGGGGAGGAGAAATCCCA
GGAGATACCTGTGACAAGTATCATGAGCAGCTAAAGGCCAAAAGAAAGGTTGTCAAAATG
ATGATTATTGTTGTCATGACATTTGCTATCTGCTGGCTGCCCTATCATATTTACTTCATT
CTCACTGCAATCTATCAACAACTAAATAGATGGAAATACATCCAGCAGGTCTACCTGGCT
AGCTTTTGGCTGGCAATGAGCTCAACCATGTACAATCCCATCATCTACTGCTGTCTGAAT
AAAAGATTTCGAGCTGGCTTCAAGAGAGCATTTCGCTGGTGTCCTTTCATCAAAGTTTCC
AGCTATGATGAGCTAGAGCTCAAGACCACCAGGTTTCATCCAAACCGGCAAAGCAGTATG
TACACCGTGACCAGAATGGAGTCCATGACAGTCGTGTTTGACCCCAACGATGCAGACACC
ACCAGGTCCAGTCGGAAGAAAAGAGCAACGCCAAGAGACCCAAGTTTCAATGGCTGCTCT
CGCAGGAATTCCAAATCTGCCTCCGCCACTTCAAGTTTCATAAGCTCACCCTATACCTCT
GTGGATGAATATTCTTAA
GenBank Gene IDM89473
GeneCard IDNot Available
GenAtlas IDTACR3
HGNC IDHGNC:11528
Chromosome Location4
Locus4q25
References
  1. Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM: cDNA sequence and heterologous expression of the human neurokinin-3 receptor. Biochem Biophys Res Commun. 1992 Apr 30;184(2):966-72. 1374246
  2. Buell G, Schulz MF, Arkinstall SJ, Maury K, Missotten M, Adami N, Talabot F, Kawashima E: Molecular characterisation, expression and localisation of human neurokinin-3 receptor. FEBS Lett. 1992 Mar 24;299(1):90-5. 1312036
  3. Takahashi K, Tanaka A, Hara M, Nakanishi S: The primary structure and gene organization of human substance P and neuromedin K receptors. Eur J Biochem. 1992 Mar 15;204(3):1025-33. 1312928
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