G1/S-specific cyclin-D1

NameG1/S-specific cyclin-D1
Synonyms
  • B-cell lymphoma 1 protein
  • BCL-1
  • BCL-1 oncogene
  • BCL1
  • PRAD1
  • PRAD1 oncogene
Gene NameCCND1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019051|G1/S-specific cyclin-D1
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Number of residues295
Molecular Weight33728.74
Theoretical pI4.68
GO Classification
Functions
  • enzyme binding
  • histone deacetylase binding
  • proline-rich region binding
  • cyclin-dependent protein serine/threonine kinase regulator activity
  • transcription corepressor activity
  • protein kinase activity
  • protein kinase binding
  • transcription factor binding
Processes
  • canonical Wnt signaling pathway
  • endoplasmic reticulum unfolded protein response
  • cell division
  • negative regulation of cell cycle arrest
  • liver development
  • lactation
  • chromatin organization
  • transcription, DNA-templated
  • fat cell differentiation
  • G1/S transition of mitotic cell cycle
  • response to ethanol
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity
  • response to vitamin E
  • cellular response to DNA damage stimulus
  • negative regulation of Wnt signaling pathway
  • Notch signaling pathway
  • positive regulation of protein phosphorylation
  • positive regulation of mammary gland epithelial cell proliferation
  • response to iron ion
  • response to estradiol
  • Leydig cell differentiation
  • response to calcium ion
  • response to magnesium ion
  • organ regeneration
  • positive regulation of G2/M transition of mitotic cell cycle
  • negative regulation of transcription from RNA polymerase II promoter
  • response to X-ray
  • mammary gland alveolus development
  • response to UV-A
  • response to organonitrogen compound
  • mammary gland epithelial cell proliferation
  • mitotic G1 DNA damage checkpoint
  • negative regulation of epithelial cell differentiation
  • mitotic cell cycle
  • re-entry into mitotic cell cycle
  • response to drug
  • response to corticosterone
Components
  • cytosol
  • nucleoplasm
  • intracellular
  • transcriptional repressor complex
  • cyclin-dependent protein kinase holoenzyme complex
  • membrane
  • nucleus
  • bicellular tight junction
General FunctionTranscription factor binding
Specific FunctionRegulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID35632
UniProtKB IDP24385
UniProtKB Entry NameCCND1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019052|G1/S-specific cyclin-D1 (CCND1)
ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCC
AACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCC
TCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTC
GCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTG
GCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAG
CTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACG
GCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGAGGAGCTGCTGCAAATG
GAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTC
ATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAA
CACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCC
TCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCC
AACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGAC
CCGGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGC
CAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAG
GTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA
GenBank Gene IDX59798
GeneCard IDNot Available
GenAtlas IDCCND1
HGNC IDHGNC:1582
Chromosome Location11
Locus11q13
References
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