ATP-dependent 6-phosphofructokinase, liver type

NameATP-dependent 6-phosphofructokinase, liver type
Synonyms
  • 2.7.1.11
  • 6-phosphofructokinase type B
  • ATP-PFK
  • PFK-B
  • Phosphofructo-1-kinase isozyme B
  • Phosphohexokinase
Gene NamePFKL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008943|ATP-dependent 6-phosphofructokinase, liver type
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
Number of residues780
Molecular Weight85017.825
Theoretical pINot Available
GO Classification
Functions
  • kinase binding
  • ATP binding
  • fructose-6-phosphate binding
  • metal ion binding
  • 6-phosphofructokinase activity
  • fructose binding
  • identical protein binding
Processes
  • negative regulation of insulin secretion
  • canonical glycolysis
  • response to glucose
  • protein oligomerization
  • fructose 6-phosphate metabolic process
  • small molecule metabolic process
  • fructose 1,6-bisphosphate metabolic process
  • carbohydrate metabolic process
  • glucose metabolic process
  • protein homotetramerization
  • glycolytic process
Components
  • membrane
  • 6-phosphofructokinase complex
  • cytosol
  • extracellular exosome
General FunctionMetal ion binding
Specific FunctionCatalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP17858
UniProtKB Entry NamePFKAL_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021726|ATP-dependent 6-phosphofructokinase, liver type (PFKL)
ATGAGAAGCATGTGTAACCAGGGTAGAGGTCGAGAGTCCTCTCGTGGGGGTCTCCATGTT
CAAGGGAGCTGCCGAGGCTTGAGCAGGAGCCCCCAGCAGGAAACTGGCTTTGCCAAGGCC
CCCGCTGGGACAGACTGTTTCTTTCACTGCAGTCCTGGGAGCCGAGGGCAAGGGGACAGG
AAAGAGGAAGTGACCTCAGAGCCTGGTGGCACCAGCATCATGTCCAGGCTGGGGGGCATG
AACGCTGCTGTCCGGGCTGTGACGCGCATGGGCATTTATGTGGGTGCCAAAGTCTTCCTC
ATCTACGAGGGCTATGAGGGCCTCGTGGAGGGAGGTGAGAACATCAAGCAGGCCAACTGG
CTGAGCGTCTCCAACATCATCCAGCTGGGCGGCACTATCATTGGCAGCGCTCGCTGCAAG
GCCTTTACCACCAGGGAGGGGCGCCGGGCAGCGGCCTACAACCTGGTCCAGCACGGCATC
ACCAACCTGTGCGTCATCGGCGGGGATGGCAGCCTCACAGGTGCCAACATCTTCCGCAGC
GAGTGGGGCAGCCTGCTGGAGGAGCTGGTGGCGGAAGGTAAGATCTCAGAGACTACAGCC
CGGACCTACTCGCACCTGAACATCGCGGGCCTAGTGGGCTCCATCGATAACGACTTCTGC
GGCACCGACATGACCATCGGCACGGACTCGGCCCTCCACCGCATCATGGAGGTCATCGAT
GCCATCACCACCACTGCCCAGAGCCACCAGAGGACCTTCGTGCTGGAAGTGATGGGCCGG
CACTGCGGGTACCTGGCGCTGGTATCTGCACTGGCCTCAGGGGCCGACTGGCTGTTCATC
CCCGAGGCTCCACCCGAGGACGGCTGGGAGAACTTCATGTGTGAGAGGCTGGGTGAGACT
CGGAGCCGTGGGTCCCGACTGAACATCATCATCATCGCTGAGGGTGCCATTGACCGCAAC
GGGAAGCCCATCTCGTCCAGCTACGTGAAGGACCTGGTGGTTCAGAGGCTGGGCTTCGAC
ACCCGTGTAACTGTGCTGGGCCACGTGCAGCGGGGAGGGACGCCCTCTGCCTTCGACCGG
ATCCTGAGCAGCAAGATGGGCATGGAGGCGGTGATGGCGCTGCTGGAAGCCACGCCTGAC
ACGCCGGCCTGCGTGGTCACCCTCTCGGGGAACCAGTCAGTGCGGCTGCCCCTCATGGAG
TGCGTGCAGATGACCAAGGAAGTGCAGAAAGCCATGGATGACAAGAGGTTTGACGAGGCC
ACCCAGCTCCGTGGTGGGAGCTTCGAGAACAACTGGAACATTTACAAGCTCCTCGCCCAC
CAGAAGCCCCCCAAGGAGAAGTCTAACTTCTCCCTGGCCATCCTGAATGTGGGGGCCCCG
GCGGCTGGCATGAATGCGGCCGTGCGCTCGGCGGTGCGGACCGGCATCTCCCATGGACAC
ACAGTATACGTGGTGCACGATGGCTTCGAAGGCCTAGCCAAGGGTCAGGTGCAAGAAGTA
GGCTGGCACGACGTGGCCGGCTGGTTGGGGCGTGGTGGCTCCATGCTGGGGACCAAGAGG
ACCCTGCCCAAGGGCCAGCTGGAGTCCATTGTGGAGAACATCCGCATCTATGGTATTCAC
GCCCTGCTGGTGGTCGGTGGGTTTGAGGCCTATGAAGGGGTGCTGCAGCTGGTGGAGGCT
CGCGGGCGCTACGAGGAGCTCTGCATCGTCATGTGTGTCATCCCAGCCACCATCAGCAAC
AACGTCCCTGGCACCGACTTCAGCCTGGGCTCCGACACTGCTGTAAATGCCGCCATGGAG
AGCTGTGACCGCATCAAACAGTCTGCCTCGGGGACCAAGCGCCGTGTGTTCATCGTGGAG
ACCATGGGGGGTTACTGTGGCTACCTGGCCACCGTGACTGGCATTGCTGTGGGGGCCGAC
GCCGCCTACGTCTTCGAGGACCCTTTCAACATCCACGACTTAAAGGTCAACGTGGAGCAC
ATGACGGAGAAGATGAAGACAGACATTCAGAGGGGCCTGGTGCTGCGGAACGAGAAGTGC
CATGACTACTACACCACGGAGTTCCTGTACAACCTGTACTCATCAGAGGGCAAGGGCGTC
TTCGACTGCAGGACCAATGTCCTGGGCCACCTGCAGCAGGGTGGCGCTCCAACCCCCTTT
GACCGGAACTATGGGACCAAGCTGGGGGTGAAGGCCATGCTGTGGTTGTCGGAGAAGCTG
CGCGAGGTTTACCGCAAGGGACGGGTGTTCGCCAATGCCCCAGACTCGGCCTGCGTGATC
GGCCTGAAGAAGAAGGCGGTGGCCTTCAGCCCCGTCACTGAGCTCAAGAAAGACACTGAT
TTCGAGCACCGCATGCCACGGGAGCAGTGGTGGCTGAGCCTGCGGCTCATGCTGAAGATG
CTGGCACAATACCGCATCAGTATGGCCGCCTACGTGTCAGGGGAGCTGGAGCACGTGACC
CGCCGCACCCTGAGCATGGACAAGGGCTTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8876
Chromosome Location21
LocusNot Available
References
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