Rho-related GTP-binding protein RhoQ

NameRho-related GTP-binding protein RhoQ
Synonyms
  • ARHQ
  • Ras-like protein family member 7A
  • Ras-like protein TC10
  • RASL7A
  • TC10
Gene NameRHOQ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009096|Rho-related GTP-binding protein RhoQ
MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG
LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG
TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII
AILTPKKHTVKKRIGSRCINCCLIT
Number of residues205
Molecular Weight22659.26
Theoretical pINot Available
GO Classification
Functions
  • GBD domain binding
  • profilin binding
  • GTP binding
  • GTPase activity
Processes
  • positive regulation of filopodium assembly
  • small GTPase mediated signal transduction
  • regulation of cell shape
  • negative regulation of establishment of protein localization to plasma membrane
  • regulation of actin cytoskeleton organization
  • insulin receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • cellular response to insulin stimulus
  • positive regulation of glucose import
  • cortical actin cytoskeleton organization
  • GTP metabolic process
  • regulation of small GTPase mediated signal transduction
Components
  • plasma membrane
  • actin filament
  • cytosol
  • extracellular exosome
  • membrane raft
  • Golgi-associated vesicle membrane
General FunctionProfilin binding
Specific FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP17081
UniProtKB Entry NameRHOQ_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013608|Rho-related GTP-binding protein RhoQ (RHOQ)
ATGGCTCACGGGCCCGGCGCGCTGATGCTCAAGTGCGTGGTGGTCGGCGACGGGGCGGTG
GGCAAGACGTGCCTACTCATGAGCTATGCCAACGACGCCTTCCCGGAGGAGTACGTGCCC
ACCGTCTTCGACCACTACGCAGTCAGCGTCACCGTGGGGGGCAAGCAGTACCTCCTAGGA
CTCTATGACACGGCCGGACAGGAAGACTATGACCGTCTGAGGCCTTTATCTTACCCAATG
ACCGATGTCTTCCTTATATGCTTCTCGGTGGTAAATCCAGCCTCATTTCAAAATGTGAAA
GAGGAGTGGGTACCGGAACTTAAGGAATACGCACCAAATGTACCCTTTTTATTAATAGGA
ACTCAGATTGATCTCCGAGATGACCCCAAAACTTTAGCAAGACTGAATGATATGAAAGAA
AAACCTATATGTGTGGAACAAGGACAGAAACTAGCAAAAGAGATAGGAGCATGCTGCTAT
GTGGAATGTTCAGCTTTAACCCAGAAGGGATTGAAGACTGTTTTTGATGAGGCTATCATA
GCCATTTTAACTCCAAAGAAACACACTGTAAAAAAAAGAATAGGATCAAGATGTATAAAC
TGTTGTTTAATTACGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17736
Chromosome Location2
LocusNot Available
References
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  7. Cheng J, Wang H, Guggino WB: Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. J Biol Chem. 2005 Feb 4;280(5):3731-9. Epub 2004 Nov 15. 15546864