D(2) dopamine receptor

NameD(2) dopamine receptor
Synonyms
  • Dopamine D2 receptor
Gene NameDRD2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001508|D(2) dopamine receptor
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
Number of residues443
Molecular Weight50618.91
Theoretical pI9.85
GO Classification
Functions
  • dopamine binding
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go
  • potassium channel regulator activity
  • drug binding
  • identical protein binding
Processes
  • negative regulation of dopamine receptor signaling pathway
  • behavioral response to cocaine
  • negative regulation of protein kinase B signaling
  • response to hypoxia
  • adenohypophysis development
  • negative regulation of cell migration
  • response to nicotine
  • regulation of locomotion involved in locomotory behavior
  • negative regulation of cytosolic calcium ion concentration
  • pigmentation
  • prepulse inhibition
  • sensory perception of smell
  • negative regulation of insulin secretion
  • synapse assembly
  • peristalsis
  • Wnt signaling pathway
  • associative learning
  • neuron-neuron synaptic transmission
  • response to inactivity
  • intracellular signal transduction
  • branching morphogenesis of a nerve
  • negative regulation of synaptic transmission, glutamatergic
  • cellular calcium ion homeostasis
  • negative regulation of innate immune response
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
  • orbitofrontal cortex development
  • temperature homeostasis
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway
  • negative regulation of blood pressure
  • activation of protein kinase activity
  • dopamine metabolic process
  • regulation of dopamine secretion
  • regulation of sodium ion transport
  • arachidonic acid secretion
  • phospholipase C-activating dopamine receptor signaling pathway
  • positive regulation of G-protein coupled receptor protein signaling pathway
  • grooming behavior
  • circadian regulation of gene expression
  • adult walking behavior
  • behavioral response to ethanol
  • response to cocaine
  • regulation of long-term neuronal synaptic plasticity
  • locomotory behavior
  • positive regulation of neuroblast proliferation
  • long-term memory
  • response to drug
  • negative regulation of protein secretion
  • synaptic transmission, dopaminergic
  • regulation of synapse structural plasticity
  • response to amphetamine
  • positive regulation of urine volume
  • visual learning
  • negative regulation of voltage-gated calcium channel activity
  • negative regulation of adenylate cyclase activity
  • striatum development
  • positive regulation of receptor internalization
  • response to iron ion
  • response to light stimulus
  • positive regulation of dopamine uptake involved in synaptic transmission
  • positive regulation of renal sodium excretion
  • regulation of cAMP metabolic process
  • regulation of synaptic transmission, GABAergic
  • G-protein coupled receptor internalization
  • positive regulation of glial cell-derived neurotrophic factor secretion
  • response to histamine
  • cerebral cortex GABAergic interneuron migration
  • response to morphine
  • neurological system process involved in regulation of systemic arterial blood pressure
  • negative regulation of dopamine secretion
  • positive regulation of cytokinesis
  • regulation of heart rate
  • positive regulation of growth hormone secretion
  • protein localization
  • response to toxic substance
  • auditory behavior
  • feeding behavior
  • phosphatidylinositol metabolic process
  • positive regulation of long-term synaptic potentiation
  • negative regulation of circadian sleep/wake cycle, sleep
  • positive regulation of multicellular organism growth
  • regulation of phosphoprotein phosphatase activity
  • negative regulation of cell proliferation
  • regulation of potassium ion transport
  • positive regulation of ERK1 and ERK2 cascade
  • regulation of dopamine uptake involved in synaptic transmission
  • axonogenesis
  • positive regulation of transcription from RNA polymerase II promoter
  • release of sequestered calcium ion into cytosol
  • response to axon injury
Components
  • ciliary membrane
  • nonmotile primary cilium
  • axon terminus
  • dendrite
  • dendritic spine
  • intracellular
  • plasma membrane
  • sperm flagellum
  • postsynaptic density
  • axon
  • cytosol
  • lateral plasma membrane
  • perikaryon
  • integral component of plasma membrane
  • endocytic vesicle
  • synaptic vesicle membrane
  • acrosomal vesicle
General FunctionPotassium channel regulator activity
Specific FunctionDopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Pfam Domain Function
Transmembrane Regions38-60 71-93 109-130 152-172 189-213 374-395 410-431
GenBank Protein ID181432
UniProtKB IDP14416
UniProtKB Entry NameDRD2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021274|D(2) dopamine receptor (DRD2)
ATGGATCCACTGAATCTGTCCTGGTATGATGATGATCTGGAGAGGCAGAACTGGAGCCGG
CCCTTCAACGGGTCAGACGGGAAGGCGGACAGACCCCACTACAACTACTATGCCACACTG
CTCACCCTGCTCATCGCTGTCATCGTCTTCGGCAACGTGCTGGTGTGCATGGCTGTGTCC
CGCGAGAAGGCGCTGCAGACCACCACCAACTACCTGATCGTCAGCCTCGCAGTGGCCGAC
CTCCTCGTCGCCACACTGGTCATGCCCTGGGTTGTCTACCTGGAGGTGGTAGGTGAGTGG
AAATTCAGCAGGATTCACTGTGACATCTTCGTCACTCTGGACGTCATGATGTGCACGGCG
AGCATCCTGAACTTGTGTGCCATCAGCATCGACAGGTACACAGCTGTGGCCATGCCCATG
CTGTACAATACGCGCTACAGCTCCAAGCGCCGGGTCACCGTCATGATCTCCATCGTCTGG
GTCCTGTCCTTCACCATCTCCTGCCCACTCCTCTTCGGACTCAATAACGCAGACCAGAAC
GAGTGCATCATTGCCAACCCGGCCTTCGTGGTCTACTCCTCCATCGTCTCCTTCTACGTG
CCCTTCATTGTCACCCTGCTGGTCTACATCAAGATCTACATTGTCCTCCGCAGACGCCGC
AAGCGAGTCAACACCAAACGCAGCAGCCGAGCTTTCAGGGCCCACCTGAGGGCTCCACTA
AAGGGCAACTGTACTCACCCCGAGGACATGAAACTCTGCACCGTTATCATGAAGTCTAAT
GGGAGTTTCCCAGTGAACAGGCGGAGAGTGGAGGCTGCCCGGCGAGCCCAGGAGCTGGAG
ATGGAGATGCTCTCCAGCACCAGCCCACCCGAGAGGACCCGGTACAGCCCCATCCCACCC
AGCCACCACCAGCTGACTCTCCCCGACCCGTCCCACCATGGTCTCCACAGCACTCCCGAC
AGCCCCGCCAAACCAGAGAAGAATGGGCATGCCAAAGACCACCCCAAGATTGCCAAGATC
TTTGAGATCCAGACCATGCCCAATGGCAAAACCCGGACCTCCCTCAAGACCATGAGCCGT
AGGAAGCTCTCCCAGCAGAAGGAGAAGAAAGCCACTCAGATGCTCGCCATTGTTCTCGGC
GTGTTCATCATCTGCTGGCTGCCCTTCTTCATCACACACATCCTGAACATACACTGTGAC
TGCAACATCCCGCCTGTCCTGTACAGCGCCTTCACGTGGCTGGGCTATGTCAACAGCGCC
GTGAACCCCATCATCTACACCACCTTCAACATTGAGTTCCGCAAGGCCTTCCTGAAGATC
CTCCACTGCTGA
GenBank Gene IDM30625
GeneCard IDNot Available
GenAtlas IDDRD2
HGNC IDHGNC:3023
Chromosome Location11
Locus11q23
References
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  3. Robakis NK, Mohamadi M, Fu DY, Sambamurti K, Refolo LM: Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region. Nucleic Acids Res. 1990 Mar 11;18(5):1299. 2138729
  4. Grandy DK, Marchionni MA, Makam H, Stofko RE, Alfano M, Frothingham L, Fischer JB, Burke-Howie KJ, Bunzow JR, Server AC, et al.: Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9762-6. 2532362
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