Interleukin-6

NameInterleukin-6
Synonyms
  • B-cell stimulatory factor 2
  • BSF-2
  • CDF
  • CTL differentiation factor
  • Hybridoma growth factor
  • IFN-beta-2
  • IFNB2
  • IL-6
  • Interferon beta-2
Gene NameIL6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021838|Interleukin-6
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Number of residues212
Molecular Weight23717.965
Theoretical pI6.52
GO Classification
Functions
  • growth factor activity
  • cytokine activity
  • interleukin-6 receptor binding
Processes
  • cell growth
  • response to amino acid
  • response to auditory stimulus
  • acute-phase response
  • regulation of circadian sleep/wake cycle, non-REM sleep
  • muscle cell cellular homeostasis
  • regulation of cell shape
  • monocyte chemotaxis
  • regulation of angiogenesis
  • positive regulation of protein import into nucleus, translocation
  • positive regulation of cell proliferation
  • defense response to Gram-positive bacterium
  • platelet activation
  • endocrine pancreas development
  • defense response to Gram-negative bacterium
  • negative regulation of gluconeogenesis
  • positive regulation of interleukin-6 production
  • defense response to virus
  • cell redox homeostasis
  • response to heat
  • positive regulation of chemokine production
  • positive regulation of T-helper 2 cell differentiation
  • response to calcium ion
  • response to glucocorticoid
  • positive regulation of JAK-STAT cascade
  • negative regulation of protein kinase activity
  • positive regulation of tyrosine phosphorylation of Stat3 protein
  • positive regulation of T cell proliferation
  • response to peptidoglycan
  • response to nutrient levels
  • defense response to protozoan
  • glucose homeostasis
  • response to cold
  • positive regulation of osteoblast differentiation
  • negative regulation of fat cell differentiation
  • cellular response to lipopolysaccharide
  • cellular response to interleukin-1
  • positive regulation of apoptotic process
  • positive regulation of protein kinase B signaling
  • aging
  • neutrophil mediated immunity
  • bone remodeling
  • negative regulation of neuron death
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of immunoglobulin secretion
  • cellular response to dexamethasone stimulus
  • interleukin-6-mediated signaling pathway
  • response to drug
  • cytokine-mediated signaling pathway
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • positive regulation of transmission of nerve impulse
  • cellular response to hydrogen peroxide
  • response to antibiotic
  • positive regulation of DNA replication
  • regulation of vascular endothelial growth factor production
  • cellular response to tumor necrosis factor
  • negative regulation of chemokine biosynthetic process
  • response to electrical stimulus
  • hepatic immune response
  • response to insulin
  • positive regulation of STAT protein import into nucleus
  • positive regulation of transcription, DNA-templated
  • response to yeast
  • response to caffeine
  • negative regulation of collagen biosynthetic process
  • neuron projection development
  • positive regulation of leukocyte chemotaxis
  • negative regulation of apoptotic process
  • positive regulation of translation
  • negative regulation of hormone secretion
  • glucagon secretion
  • positive regulation of epithelial cell proliferation
  • positive regulation of acute inflammatory response
  • negative regulation of cell proliferation
  • positive regulation of nitric oxide biosynthetic process
  • positive regulation of MAPK cascade
  • negative regulation of muscle organ development
  • humoral immune response
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of B cell activation
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • neutrophil apoptotic process
  • positive regulation of type B pancreatic cell apoptotic process
  • T-helper 17 cell lineage commitment
  • inflammatory response
  • positive regulation of smooth muscle cell proliferation
  • negative regulation of cytokine secretion
  • positive regulation of peptidyl-serine phosphorylation
  • branching involved in salivary gland morphogenesis
  • positive regulation of neuron differentiation
  • negative regulation of lipid storage
  • positive regulation of transcription from RNA polymerase II promoter
  • epithelial cell proliferation involved in salivary gland morphogenesis
Components
  • cytoplasm
  • extracellular region
  • external side of plasma membrane
  • interleukin-6 receptor complex
  • extracellular space
General FunctionInterleukin-6 receptor binding
Specific FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID32674
UniProtKB IDP05231
UniProtKB Entry NameIL6_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021839|Interleukin-6 (IL6)
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG
GenBank Gene IDX04430
GeneCard IDNot Available
GenAtlas IDIL6
HGNC IDHGNC:6018
Chromosome Location7
Locus7p21
References
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