T3DB: Adhesion G protein-coupled receptor L2

Name	Adhesion G protein-coupled receptor L2
Synonyms	Calcium-independent alpha-latrotoxin receptor 2 CIRL-2 KIAA0786 Latrophilin homolog 1 Latrophilin-2 LEC1 Lectomedin-1 LPHH1 LPHN2
Gene Name	ADGRL2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009043\|Adhesion G protein-coupled receptor L2 MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE GCIPEGDVREGQMQLVTSL
Number of residues	1459
Molecular Weight	163347.39
Theoretical pI	Not Available
GO Classification	Functions G-protein coupled receptor activity carbohydrate binding latrotoxin receptor activity Processes G-protein coupled receptor signaling pathway cell surface receptor signaling pathway positive regulation of synapse assembly Components integral component of membrane
General Function	Latrotoxin receptor activity
Specific Function	Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.
Pfam Domain Function	7tm_2 (PF00002 ) HRM (PF02793 ) GPS (PF01825 ) GAIN (PF16489 ) Gal_Lectin (PF02140 ) Latrophilin (PF02354 ) OLF (PF02191 )
Transmembrane Regions	852-872 881-901 908-928 953-973 991-1011 1038-1058 1063-1083
GenBank Protein ID	Not Available
UniProtKB ID	O95490
UniProtKB Entry Name	AGRL2_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0013581\|Adhesion G protein-coupled receptor L2 (ADGRL2) ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTA CCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTA TCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAG AGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAG AATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAGGTGCAACAATCGA ACACAGTGTATAGTAGTTACTGGGTCAGATGTGTTTCCTGATCCATGTCCTGGAACATAC AAATACCTTGAAGTCCAATATGAATGTGTCCCTTACATTTTTGTGTGTCCTGGGACCTTG AAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCGGGTGCTTGGTGC AAGGACCCTCTTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACTCCCTATCGTACC GATACTTTAATAGAATATGCTTCTTTAGAAGATTTCCAAAATAGTCGCCAAACAACAACA TATAAACTTCCAAATCGAGTAGATGGTACTGGATTTGTGGTGTATGATGGTGCTGTCTTC TTTAACAAAGAAAGAACGAGGAATATTGTGAAATTTGACTTGAGGACTAGAATTAAGAGT GGCGAGGCCATAATTAACTATGCCAACTACCATGATACCTCACCATACAGATGGGGAGGA AAGACTGATATCGACCTAGCAGTTGATGAAAATGGTTTATGGGTCATTTACGCCACTGAA CAGAACAATGGAATGATAGTTATTAGCCAGCTGAATCCATACACTCTTCGATTTGAAGCA ACGTGGGAGACTGTATACGACAAACGTGCCGCATCAAATGCTTTTATGATATGCGGAGTC CTCTATGTGGTTAGGTCAGTTTATCAAGACAATGAAAGTGAAACAGGCAAGAACTCAATT GATTACATTTATAATACCCGATTAAACCGAGGAGAATATGTAGATGTTCCCTTCCCCAAC CAGTATCAGTATATTGCTGCAGTGGATTACAATCCAAGAGATAACCAACTTTACGTGTGG AACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGATCCTGCCCAAGTG CCTACCACAGCTGTGACAATAACTTCTTCAGCTGAGCTGTTCAAAACCATAATATCAACC ACAAGCACTACTTCACAGAAAGGCCCCATGAGCACAACTGTAGCTGGATCACAGGAAGGA AGCAAAGGGACAAAACCACCTCCAGCAGTTTCTACAACCAAAATTCCACCTATAACAAAT ATTTTTCCCCTGCCAGAGAGATTCTGTGAAGCATTAGACTCCAAGGGGATAAAGTGGCCT CAGACACAAAGGGGAATGATGGTTGAACGACCATGCCCTAAGGGAACAAGAGGAACTGCC TCATATCTCTGCATGATTTCCACTGGAACATGGAACCCTAAGGGCCCCGATCTTAGCAAC TGTACCTCACACTGGGTGAATCAGCTGGCTCAGAAGATCAGAAGCGGAGAAAATGCTGCT AGTCTTGCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGGGATGTAAGT TCTTCAGTGAGATTGATGGAGCAGTTGGTGGACATCCTTGATGCACAGCTGCAGGAACTG AAACCTAGTGAAAAAGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGACACAGTG GACAACCTTCTGAGACCCGAAGCTTTGGAATCATGGAAACATATGAATTCTTCTGAACAA GCACATACTGCAACAATGTTACTCGATACATTGGAAGAAGGAGCTTTTGTCCTAGCTGAC AATCTTTTAGAACCAACAAGGGTCTCAATGCCCACAGAAAATATTGTCCTGGAAGTTGCC GTACTCAGTACAGAAGGACAGATCCAAGACTTTAAATTTCCTCTGGGCATCAAAGGAGCA GGCAGCTCAATCCAACTGTCCGCAAATACCGTCAAACAGAACAGCAGGAATGGGCTTGCA AAGTTGGTGTTCATCATTTACCGGAGCCTGGGACAGTTCCTTAGTACAGAAAATGCAACC ATTAAACTGGGTGCTGATTTTATTGGTCGTAATAGCACCATTGCAGTGAACTCTCACGTC ATTTCAGTTTCAATCAATAAAGAGTCCAGCCGAGTATACCTGACTGATCCTGTGCTTTTT ACCCTGCCACACATTGATCCTGACAATTATTTCAATGCAAACTGCTCCTTCTGGAACTAC TCAGAGAGAACTATGATGGGATATTGGTCTACCCAGGGCTGCAAGCTGGTTGACACTAAT AAAACTCGAACAACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCTCATGGCCCAC AGGGAAATTGCATATAAAGATGGCGTTCATGAATTACTTCTTACAGTCATCACCTGGGTG GGAATTGTCATTTCCCTTGTTTGCCTGGCTATCTGCATCTTCACCTTCTGCTTTTTCCGT GGCCTACAGAGTGACCGAAATACTATTCACAAGAACCTTTGTATCAACCTTTTCATTGCT GAATTTATTTTCCTAATAGGCATTGATAAGACAAAATATGCGATTGCATGCCCAATATTT GCAGGACTTCTACACTTTTTCTTTTTGGCAGCTTTTGCTTGGATGTGCCTAGAAGGTGTG CAGCTCTACCTAATGTTAGTTGAAGTTTTTGAAAGTGAATATTCAAGGAAAAAATATTAC TATGTTGCTGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGCTATTGACTAT AAGAGCTATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTACTTTATATGGAGC TTCATTGGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTCTTGGTGATCACATTG TGCAAAATGGTGAAGCATTCAAACACTTTGAAACCAGATTCTAGCAGGTTGGAAAACATT AAGTCTTGGGTGCTTGGCGCTTTCGCTCTTCTGTGTCTTCTTGGCCTCACCTGGTCCTTT GGGTTGCTTTTTATTAATGAGGAGACTATTGTGATGGCATATCTCTTCACTATATTTAAT GCTTTCCAGGGAGTGTTCATTTTCATCTTTCACTGTGCTCTCCAAAAGAAAGTACGAAAA GAATATGGCAAGTGCTTCAGACACTCATACTGCTGTGGAGGCCTCCCAACTGAGAGTCCC CACAGTTCAGTGAAGGCATCAACCACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAG AGTCGTATAAGAAGAATGTGGAATGATACTGTGAGAAAACAATCAGAATCTTCTTTTATC TCAGGTGACATCAATAGCACTTCAACACTTAATCAAGGACATTCACTGAACAATGCCAGG GATACAAGTGCCATGGATACTCTACCGCTAAATGGTAATTTTAACAACAGCTACTCGCTG CACAAGGGTGACTATAATGACAGCGTGCAAGTTGTGGACTGTGGACTAAGTCTGAATGAT ACTGCTTTTGAGAAAATGATCATTTCAGAATTAGTGCACAACAACTTACGGGGCAGCAGC AAGACTCACAACCTCGAGCTCACGCTACCAGTCAAACCTGTGATTGGAGGTAGCAGCAGT GAAGATGATGCTATTGTGGCAGATGCTTCATCTTTAATGCACAGCGACAACCCAGGGCTG GAGCTCCATCACAAAGAACTCGAGGCACCACTTATTCCTCAGCGGACTCACTCCCTTCTG TACCAACCCCAGAAGAAAGTGAAGTCCGAGGGAACTGACAGCTATGTCTCCCAACTGACA GCAGAGGCTGAAGATCACCTACAGTCCCCCAACAGAGACTCTCTTTATACAAGCATGCCC AATCTTAGAGACTCTCCCTATCCGGAGAGCAGCCCTGACATGGAAGAAGACCTCTCTCCC TCCAGGAGGAGTGAGAATGAGGACATTTACTATAAAAGCATGCCAAATCTTGGAGCTGGC CATCAGCTTCAGATGTGCTACCAGATCAGCAGGGGCAATAGTGATGGTTATATAATCCCC ATTAACAAAGAAGGGTGTATTCCAGAAGGAGATGTTAGAGAAGGACAAATGCAGCTGGTT ACAAGTCTTTAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:18582
Chromosome Location	1
Locus	Not Available
References	White GR, Varley JM, Heighway J: Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene. 1998 Dec 31;17(26):3513-9. 10030676 White GR, Varley JM, Heighway J: Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. Biochim Biophys Acta. 2000 Apr 25;1491(1-3):75-92. 10760572 Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. 16710414 Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Oct 30;5(5):277-86. 9872452 Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE: Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol. 2007;8(4):R64. 17456239 Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. 19159218 Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460 Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. 21406692 Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569 Hamann J, Aust G, Arac D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Promel S, Schoneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schioth HB: International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647. 25713288