Potassium channel subfamily K member 2

NamePotassium channel subfamily K member 2
Synonyms
  • Outward rectifying potassium channel protein TREK-1
  • TREK
  • TREK-1 K(+) channel subunit
  • TREK1
  • Two pore domain potassium channel TREK-1
  • Two pore potassium channel TPKC1
Gene NameKCNK2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0036972|Potassium channel subfamily K member 2
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
Number of residues426
Molecular Weight47092.215
Theoretical pI8.88
GO Classification
Functions
  • potassium ion leak channel activity
  • outward rectifier potassium channel activity
  • potassium channel inhibitor activity
Processes
  • cellular response to hypoxia
  • cochlea development
  • memory
  • synaptic transmission
  • negative regulation of cardiac muscle cell proliferation
  • negative regulation of DNA biosynthetic process
  • positive regulation of cell death
  • G-protein coupled receptor signaling pathway
  • positive regulation of cellular response to hypoxia
  • response to axon injury
  • potassium ion transmembrane transport
  • response to mechanical stimulus
  • stabilization of membrane potential
  • cardiac ventricle development
Components
  • voltage-gated potassium channel complex
  • endoplasmic reticulum membrane
  • cell surface
  • integral component of plasma membrane
  • apical plasma membrane
  • astrocyte projection
  • calyx of Held
  • nucleus
  • neuronal cell body
  • endoplasmic reticulum
  • plasma membrane
General FunctionPotassium ion leak channel activity
Specific FunctionIon channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.
Pfam Domain Function
Transmembrane Regions62-82 172-192 224-244 288-308
GenBank Protein ID5712621
UniProtKB IDO95069
UniProtKB Entry NameKCNK2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010008|Potassium channel subfamily K member 2 (KCNK2)
ATGATGAACCCACGAGCAAAAAGGGATTTCTACTTGGCGGCACCTGACTTGCTGGATCCT
AAATCTGCCGCTCAGAACTCCAAACCGAGGCTCTCGTTTTCCACGAAACCCACAGTGCTT
GCTTCCCGGGTGGAGAGTGACACGACCATTAATGTTATGAAATGGAAGACGGTCTCCACG
ATATTCCTGGTGGTTGTCCTCTATCTGATCATCGGAGCCACCGTGTTCAAAGCATTGGAG
CAGCCTCATGAGATTTCACAGAGGACCACCATTGTGATCCAGAAGCAAACATTCATATCC
CAACATTCCTGTGTCAATTCGACGGAGCTGGATGAACTCATTCAGCAAATAGTGGCAGCA
ATAAATGCAGGGATTATACCGTTAGGAAACACCTCCAATCAAATCAGTCACTGGGATTTG
GGAAGTTCCTTCTTCTTTGCTGGCACTGTTATTACAACCATAGGATTTGGAAACATCTCA
CCACGCACAGAAGGCGGCAAAATATTCTGTATCATCTATGCCTTACTGGGAATTCCCCTC
TTTGGTTTTCTCTTGGCTGGAGTTGGAGATCAGCTAGGCACCATATTTGGAAAAGGAATT
GCCAAAGTGGAAGATACGTTTATTAAGTGGAATGTTAGTCAGACCAAGATTCGCATCATC
TCAACAATCATATTTATACTATTTGGCTGTGTACTCTTTGTGGCTCTGCCTGCGATCATA
TTCAAACACATAGAAGGCTGGAGTGCCCTGGACGCCATTTATTTTGTGGTTATCACTCTA
ACAACTATTGGATTTGGTGACTACGTTGCAGGTGGATCCGATATTGAATATCTGGACTTC
TATAAGCCTGTCGTGTGGTTCTGGATCCTTGTAGGGCTTGCTTACTTTGCTGCTGTCCTG
AGCATGATTGGAGATTGGCTCCGAGTGATATCTAAAAAGACAAAAGAAGAGGTGGGAGAG
TTCAGAGCACACGCTGCTGAGTGGACAGCCAACGTCACAGCCGAATTCAAAGAAACCAGG
AGGCGACTGAGTGTGGAGATTTATGACAAGTTCCAGCGGGCCACCTCCATCAAGCGGAAG
CTCTCGGCAGAACTGGCTGGAAACCACAATCAGGAGCTGACTCCTTGTAGGAGGACCCTG
TCAGTGAACCACCTGACCAGCGAGAGGGATGTCTTGCCTCCCTTACTGAAGACTGAGAGT
ATCTATCTGAATGGTTTGACGCCACACTGTGCTGGTGAAGAGATTGCTGTGATTGAGAAC
ATCAAATAG
GenBank Gene IDAF129399
GeneCard IDNot Available
GenAtlas IDKCNK2
HGNC IDHGNC:6277
Chromosome Location1
Locus1q41
References
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  2. Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG: Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. 10784345
  3. Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R: A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013 Nov 7. 24196565
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