Protein phosphatase 1 regulatory subunit 12B

NameProtein phosphatase 1 regulatory subunit 12B
Synonyms
  • Myosin phosphatase target subunit 2
  • Myosin phosphatase-targeting subunit 2
  • MYPT2
Gene NamePPP1R12B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009116|Protein phosphatase 1 regulatory subunit 12B
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
GVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK
SDNQRLKDENGALIRVISKLSK
Number of residues982
Molecular Weight110402.735
Theoretical pINot Available
GO Classification
Functions
  • enzyme activator activity
  • phosphatase regulator activity
Processes
  • positive regulation of catalytic activity
  • regulation of muscle contraction
  • signal transduction
  • small GTPase mediated signal transduction
  • G2/M transition of mitotic cell cycle
  • mitotic cell cycle
Components
  • A band
  • plasma membrane
  • actin cytoskeleton
  • cytosol
  • nucleoplasm
  • Z disc
General FunctionPhosphatase regulator activity
Specific FunctionRegulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO60237
UniProtKB Entry NameMYPT2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017695|Protein phosphatase 1 regulatory subunit 12B (PPP1R12B)
ATGGCGGAACTGGAGCACCTAGGAGGGAAGCGGGCAGAGTCGGCGCGAATGCGGCGGGCA
GAGCAGCTTCGGCGCTGGCGGGGCTCGCTGACAGAGCAGGAGCCTGCGGAGCGACGAGGC
GCGGGGCGGCAGCCGCTGACCAGGCGCGGGAGCCCCAGGGTCCGCTTCGAGGACGGTGCT
GTCTTTCTGGCCGCCTGCTCTAGCGGGGACACCGACGAGGTGAGAAAGCTTCTGGCAAGA
GGTGCTGATATCAACACGGTCAACGTGGACGGCTTGACAGCCCTGCACCAGGCATGTATT
GATGAAAATTTGGACATGGTGAAGTTTCTGGTGGAGAACAGAGCCAATGTAAACCAGCAA
GACAACGAGGGCTGGACACCCCTTCATGCAGCAGCTTCCTGTGGCTATCTCAACATAGCA
GAGTATTTCATTAATCACGGAGCCAGTGTAGGTATTGTCAATAGTGAAGGTGAAGTTCCC
TCTGACCTTGCAGAAGAGCCAGCCATGAAGGATCTTCTTCTGGAGCAAGTAAAGAAGCAA
GGAGTTGATCTAGAGCAGTCAAGAAAAGAAGAAGAGCAGCAGATGTTGCAGGATGCCCGC
CAGTGGCTCAACAGTGGGAAAATAGAGGATGTGAGGCAGGCTCGCTCAGGGGCTACAGCC
CTTCATGTGGCTGCTGCCAAGGGCTACTCTGAAGTCCTCAGACTTTTAATTCAGGCTGGC
TATGAACTCAATGTTCAGGATTATGATGGCTGGACTCCCCTCCATGCTGCTGCACACTGG
GGAGTGAAGGAGGCTTGCTCCATCCTGGCAGAAGCACTTTGTGACATGGATATTCGAAAT
AAACTGGGCCAGACACCATTTGATGTGGCTGATGAGGGTCTCGTGGAGCATTTGGAGTTG
CTCCAGAAGAAGCAGAATGTGCTTCGAAGTGAAAAGGAGACACGGAATAAACTCATTGAG
TCAGATCTGAACAGCAAGATTCAGAGTGGGTTCTTTAAGAACAAAGAGAAGATGCTCTAT
GAGGAGGAGACACCTAAGTCCCAAGAAATGGAGGAAGAAAATAAAGAATCTAGTAGCTCC
AGCTCAGAGGAGGAGGAAGGTGAAGATGAAGCTTCTGAGTCAGAAACTGAGAAGGAGGCA
GATAAAAAGCCAGAAGCCTTTGTCAATCATTCCAACTCTGAAAGCAAGAGTAGTATCACA
GAGCAGATACCAGCACCAGCTCAAAATACCTTCTCTGCCTCTTCTGCTAGGAGGTTCTCT
TCTGGCCTTTTTAACAAGCCAGAAGAGCCCAAAGATGAATCTCCTTCTTCATGGAGATTG
GGACTGAGAAAAACTGGCAGCCACAACATGCTGAGTGAGGTGGCCAATTCCAGGGAACCT
ATAAGGGACCGAGGCTCTTCCATCTATCGCTCCTCTTCAAGCCCTCGGATTTCTGCTCTA
CTGGACAACAAAGATAAGGTGCAGTTTGGGAGGGTATGGGGGAATTCCAAGGCAGTTTTT
TTTTTCCATGAAAATTCAATCTTAGGAACAAATGAAAATATTTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:7619
Chromosome Location1
LocusNot Available
References
  1. Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M: A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. Genomics. 1998 Apr 1;49(1):59-68. 9570949
  2. Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A: Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. J Biol Chem. 2001 Mar 2;276(9):6073-82. Epub 2000 Nov 6. 11067852
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