T3DB: Kinesin-like protein KIF1C

Name	Kinesin-like protein KIF1C
Synonyms	KIAA0706
Gene Name	KIF1C
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009152\|Kinesin-like protein KIF1C MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHT STEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVP QLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQD LSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEK VSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPY RDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNA RLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHN GELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMG VAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIR EQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP EQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEE ADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRR APRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMR ELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKL TGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAE EAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGG GLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRP PSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPP YTTPPRMRRQRSAPDLKESGAAV
Number of residues	1103
Molecular Weight	122945.52
Theoretical pI	Not Available
GO Classification	Functions poly(A) RNA binding ATP-dependent microtubule motor activity, plus-end-directed ATP binding motor activity Processes cytoskeleton-dependent intracellular transport retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement Components kinesin complex microtubule endoplasmic reticulum Golgi apparatus
General Function	Poly(a) rna binding
Specific Function	Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Pfam Domain Function	Kinesin (PF00225 ) FHA (PF00498 ) Kinesin_assoc (PF16183 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	O43896
UniProtKB Entry Name	KIF1C_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0019725\|Kinesin-like protein KIF1C (KIF1C) ATGGCTGGTGCCTCGGTGAAAGTGGCAGTGAGGGTTCGGCCCTTTAACGCCCGTGAGACC AGCCAGGATGCCAAGTGTGTGGTCAGCATGCAGGGCAACACCACCTCCATCATCAATCCT AAACAGAGCAAGGATGCCCCCAAAAGCTTCACCTTTGACTACTCCTACTGGTCACACACT TCGACGGAGGACCCCCAGTTTGCATCTCAGCAGCAAGTGTATCGGGACATTGGAGAAGAG ATGCTGCTCCACGCCTTTGAAGGCTACAACGTGTGCATCTTTGCCTATGGGCAGACCGGG GCTGGGAAATCCTATACCATGATGGGGCGACAGGAGCCAGGGCAGCAGGGCATCGTGCCC CAGCTCTGTGAGGACCTCTTCTCTCGCGTTAGTGAGAACCAGAGTGCTCAGCTATCCTAC TCTGTGGAGGTGAGCTATATGGAGATCTACTGTGAGCGGGTACGAGACCTCTTGAACCCC AAGAGTCGGGGTTCTCTGCGGGTCCGGGAGCACCCCATCCTGGGCCCGTACGTGCAGGAC CTGTCCAAATTGGCTGTGACCTCCTACGCAGACATTGCTGACCTCATGGACTGTGGAAAT AAAGCACGGACTGTGGCTGCCACCAACATGAATGAGACCAGCAGCCGTTCCCATGCCGTC TTTACCATCGTCTTCACACAGCGCTGCCATGACCAGCTCACGGGGCTGGACTCGGAGAAG GTCAGTAAGATCAGTTTGGTGGACCTTGCTGGGAGTGAGCGAGCCGACTCCTCAGGGGCC CGGGGCATGCGCCTGAAGGAAGGAGCCAACATCAATAAGTCCCTGACTACACTAGGGAAA GTGATCTCGGCCCTTGCAGATATGCAATCAAAGAAGCGAAAGTCGGATTTTATCCCCTAC AGGGACTCTGTGCTCACCTGGCTGCTCAAGGAAAATTTGGGGGGGAACTCACGCACAGCC ATGATTGCAGCCCTGAGCCCTGCTGACATCAATTACGAGGAGACTCTCAGCACCCTCAGG TATGCTGACCGCACCAAGCAAATCCGCTGCAATGCCATCATCAACGAGGACCCTAATGCC CGGCTGATTAGAGAGCTGCAGGAGGAAGTAGCCCGGCTGCGGGAACTGCTGATGGCTCAG GGACTGTCAGCCTCTGCTCTGGAAGGCCTGAAGACGGAAGAAGGGAGTGTCAGAGGCGCC CTGCCAGCTGTGTCATCTCCCCCAGCTCCAGTTTCACCCTCATCACCCACCACACATAAT GGGGAGCTGGAGCCGTCATTCTCCCCCAACACGGAGTCCCAGATTGGGCCTGAGGAAGCC ATGGAGAGGCTGCAGGAGACAGAGAAGATTATAGCTGAGCTGAACGAGACATGGGAGGAG AAGCTACGCAAGACAGAAGCCCTGAGGATGGAGAGAGAAGCATTGCTGGCTGAGATGGGG GTGGCCGTCCGGGAGGATGGGGGAACTGTGGGCGTCTTCTCTCCAAAGAAGACTCCCCAC CTGGTGAACCTGAACGAAGACCCTCTGATGTCTGAGTGTCTGCTCTACCACATCAAAGAT GGCGTCACCAGGGTCGGCCAAGTAGATATGGACATCAAGCTGACCGGACAGTTCATTCGG GAGCAACACTGTCTGTTCCGGAGCATCCCCCAGCCAGATGGAGAAGTGGTGGTCACTCTG GAGCCTTGTGAAGGAGCTGAGACATATGTGAATGGGAAGCTTGTGACGGAGCCGCTGGTG CTGAAGTCAGGGAATAGGATTGTGATGGGCAAGAACCACGTTTTCCGCTTCAACCACCCG GAGCAGGCAAGGCTGGAACGGGAACGAGGGGTCCCCCCACCCCCAGGACCGCCCTCTGAG CCAGTCGACTGGAACTTTGCCCAGAAGGAACTGCTGGAGCAGCAAGGCATCGACATAAAG CTGGAAATGGAGAAGAGGCTGCAGGATCTGGAGAATCAGTACCGGAAAGAAAAGGAAGAA GCCGATCTTCTGCTGGAGCAGCAGCGACTGTATGCAGACTCGGACAGCGGGGATGACTCT GACAAGCGCTCTTGTGAAGAGAGCTGGAGGCTCATCTCCTCCTTGCGGGAGCAGCTGCCG CCCACCACGGTCCAGACCATTGTCAAACGCTGTGGTCTGCCCAGCAGTGGCAAGCGCAGG GCCCCTCGCAGGGTTTATCAGATCCCCCAGCGACGCAGGCTGCAGGGCAAAGACCCCCGC TGGGCCACCATGGCTGACCTGAAGATGCAGGCGGTGAAGGAGATCTGCTACGAGGTGGCC CTGGCTGACTTCCGCCACGGGCGGGCTGAGATTGAGGCCCTGGCCGCCCTCAAGATGCGG GAGCTGTGTCGCACCTATGGCAAGCCAGACGGCCCCGGAGACGCCTGGAGGGCTGTGGCC CGGGATGTCTGGGACACTGTAGGCGAGGAGGAAGGAGGTGGAGCTGGCAGTGGTGGTGGC AGTGAGGAGGGAGCCCGAGGGGCGGAGGTGGAGGACCTCCGGGCCCACATCGACAAGCTG ACGGGGATTCTGCAGGAGGTGAAGCTGCAGAACAGCAGCAAGGACCGGGAGCTGCAGGCC CTGCGGGACCGCATGCTCCGCATGGAGAGGGTCATCCCCCTGGCCCAGGATCATGAGGAT GAGAATGAAGAAGGTGGTGAGGTCCCCTGGGCCCCGCCTGAAGGATCAGAGGCAGCAGAG GAGGCAGCCCCCAGTGACCGCATGCCGTCAGCCCGGCCCCCCTCGCCACCACTGTCAAGC TGGGAGCGGGTGTCACGGCTCATGGAGGAGGACCCTGCCTTCCGTCGTGGTCGTCTTCGC TGGCTCAAGCAGGAGCAGCTACGGCTGCAGGGACTGCAGGGCTCTGGGGGCCGGGGCGGG GGGCTGCGCAGGCCCCCAGCCCGCTTTGTGCCCCCTCACGACTGCAAGCTACGCTTCCCC TTCAAGAGCAACCCCCAGCACCGGGAGTCTTGGCCAGGGATGGGGAGCGGGGAGGCTCCA ACTCCGCTCCAACCCCCTGAGGAGGTCACTCCCCATCCAGCCACCCCTGCCCGCCGGCCT CCGAGTCCCCGAAGGTCCCACCATCCCCGCAGGAACTCCCTGGATGGAGGGGGCCGATCC CGGGGAGCGGGTTCTGCACAGCCTGAACCCCAGCACTTCCAGCCCAAAAAGCACAACTCT TATCCCCAGCCACCCCAACCCTACCCAGCCCAGCGGCCCCCAGGGCCCCGCTACCCCCCA TACACTACTCCCCCACGAATGAGACGGCAGCGTTCTGCCCCTGACCTCAAGGAGAGTGGG GCAGCTGTGTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:6317
Chromosome Location	17
Locus	Not Available
References	Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R: Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum. J Biol Chem. 1998 Aug 7;273(32):20267-75. 9685376 Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. 9734811 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. 17081983 Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. 16964243 Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648 Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231 Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460 Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. 21406692 Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569 Dor T, Cinnamon Y, Raymond L, Shaag A, Bouslam N, Bouhouche A, Gaussen M, Meyer V, Durr A, Brice A, Benomar A, Stevanin G, Schuelke M, Edvardson S: KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction. J Med Genet. 2014 Feb;51(2):137-42. doi: 10.1136/jmedgenet-2013-102012. Epub 2013 Dec 6. 24319291