5-hydroxytryptamine receptor 3E

Name5-hydroxytryptamine receptor 3E
Synonyms
  • 5-HT3-E
  • Serotonin receptor 3E
Gene NameHTR3E
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008663|5-hydroxytryptamine receptor 3E
MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNI
SVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNL
WLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTF
SSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFY
VAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLL
PTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRC
CPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHS
VELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
Number of residues456
Molecular Weight51437.415
Theoretical pINot Available
GO Classification
Functions
  • serotonin receptor activity
  • serotonin-activated cation-selective channel activity
Processes
  • serotonin receptor signaling pathway
  • regulation of membrane potential
  • cation transmembrane transport
  • neurological system process
  • transmembrane transport
  • ion transmembrane transport
Components
  • plasma membrane
  • integral component of membrane
  • synapse
  • neuron projection
General FunctionSerotonin-activated cation-selective channel activity
Specific FunctionThis is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Pfam Domain Function
Transmembrane Regions249-269 283-303 308-328 434-454
GenBank Protein IDNot Available
UniProtKB IDA5X5Y0
UniProtKB Entry Name5HT3E_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021420|5-hydroxytryptamine receptor 3E (HTR3E)
ATGGAAGGAAGCTGGTTCCACAGGAAAAGATTTTCCTTCTACCTCCTTCTCGGTTTTCTG
CTTCAAGGAAGGGGCGTTACTTTCACCATCAATTGCTCAGGGTTTGGCCAGCACGGGGCG
GATCCCACTGCTCTGAATTCAGTGTTTAATAGAAAGCCCTTCCGTCCGGTCACCAACATC
AGCGTCCCCACCCAAGTCAACATCTCCTTCGCGATGTCTGCCATCCTAGATGTGAATGAA
CAGCTGCACCTCTTGTCATCATTCCTGTGGCTGGAAATGGTTTGGGATAACCCATTTATC
AGCTGGAACCCAGAGGAATGTGAGGGCATCACGAAGATGAGTATGGCAGCCAAGAACCTG
TGGCTCCCAGACATTTTCATCATTGAACTCATGGATGTGGATAAGACCCCAAAAGGCCTC
ACAGCATATGTAAGTAATGAAGGTCGCATCAGGTATAAGAAACCCATGAAGGTGGACAGT
ATCTGTAACCTGGACATCTTCTACTTCCCCTTCGACCAGCAGAACTGCACACTCACCTTC
AGCTCATTCCTCTACACAGTGGACAGCATGTTGCTGGACATGGAGAAAGAAGTGTGGGAA
ATAACAGACGCATCCCGGAACATCCTTCAGACCCATGGAGAATGGGAGCTCCTGGGCCTC
AGCAAGGCCACCGCAAAGTTGTCCAGGGGAGGCAACCTGTATGATCAGATCGTGTTCTAT
GTGGCCATCAGGCGCAGGCCCAGTCTCTATGTCATAAACCTTCTCGTGCCCAGTGGCTTT
CTGGTTGCCATCGATGCCCTCAGCTTCTACCTGCCAGTGAAAAGTGGGAATCGTGTCCCA
TTCAAGATAACGCTCCTGCTGGGCTACAACGTCTTCCTGCTCATGATGAGTGACTTGCTC
CCCACCAGTGGCACCCCCCTCATCGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTG
GGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCC
CCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGC
TGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCC
GGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTG
ACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCA
GTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTG
CTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTCTGGAACACCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:24005
Chromosome Location3
LocusNot Available
References
  1. Niesler B, Frank B, Kapeller J, Rappold GA: Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene. 2003 May 22;310:101-11. 12801637
  2. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL: A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene. 2003 Nov 13;319:137-48. 14597179
  3. Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, Bonisch H, Gothert M, Rappold G, Bruss M: Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol. 2007 Jul;72(1):8-17. Epub 2007 Mar 28. 17392525
  4. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP, Courtenay N, Luck J, Rhodes A, Modha S, Moore SE, Sanger GJ, Gunthorpe MJ: Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem. 2009 Jan;108(2):384-96. doi: 10.1111/j.1471-4159.2008.05775.x. Epub 2008 Nov 29. 19012743
  5. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. 16641997
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334